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144 (0,088s) •

Project

The efect of methylation and acetylation on chromatin structure (GP202/03/D033)

the acetylation status of histones on metaphase chromosomes of humid blood cells and hyperacetylation drugs on the level of methylation/acetylation status of histones and DNABiochemical modifications of DNA and

EB - Genetika a molekulární biologie

  • 2003 - 2006
    • •
  • 736 tis. Kč
    • •
  • 736 tis. Kč
    • •
  • GA ČR
Project

Nuclear Structure and Histone Acetylation in Plant Cells (IAA5004901)

active gene regions. Using antisera directed against acetylated isoforms of H4 and H3 andindirect immunocytochemistry we will analyse histone acetylation patterns development. Histone acetylation status w...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 4 366 tis. Kč
    • •
  • 2 079 tis. Kč
    • •
  • AV ČR
Project

Modulation of structural and functional properties of the HSP90 chaperone machinery by reversible acetylation (GA21-31806S)

, including lysine acetylation. Biological data suggest that histone deacetylase 6 (HDAC6)acetylation by HDAC6 and functional consequences of such interactions have not been acetylation. Specifically, we will purif...

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 9 135 tis. Kč
    • •
  • 9 135 tis. Kč
    • •
  • GA ČR
Project

Study of the chromatin changes during plant microsporogenesis and microgametogenesis (GA521/98/P061)

and histone acetylation in control of the chromatin structure formation and gene maturation. However, pronounced histone acetylation and DNA hypomethylation occur the dynamic status of the vegetative nucleus. Wher...

GE - Šlechtění rostlin

  • 1998 - 2000
    • •
  • 737 tis. Kč
    • •
  • 675 tis. Kč
    • •
  • GA ČR
Project

Mechanisms involved in epigenetic control of expression and function of androgen receptor (AR) in prostate cancer Potential therapeutic implications of AR coactivators blockade. (NS10262)

for binding to androgen receptor. 2/ Elucidate an effect of the inhibitor histone deacetylation on changes of covalent histone modifications. 3/ Determine whether histone modifications changes (acetylation and met...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 340 tis. Kč
    • •
  • 2 222 tis. Kč
    • •
  • MZ
Project

Regulation of alternative splicing via chromatin acetylation (GAP305/10/0424)

a novel mechanism of splicing regulation via chromatin acetylation. Our substantial preliminary data show that inhibition or depletion of histone deacetylases influences with nascent pre-mRNA during transcription. We propose to fol...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 4 813 tis. Kč
    • •
  • 4 813 tis. Kč
    • •
  • GA ČR
Project

Redox signalling to chromatin during stress responses in plants (GA22-17092S)

transcriptional co-activator, is involved in histone acetylation and regulates numerous stress the genome-wide distribution of histone acetylation marks deposited by the SAGA complex histone modifications...

Plant sciences, botany

  • 2022 - 2024
    • •
  • 4 911 tis. Kč
    • •
  • 4 911 tis. Kč
    • •
  • GA ČR
Project

Postranslational modifications of histones after cell treatment by inhibitors of histone deacetylases and during induction of cell differentiation (GA204/06/0978)

Postranslational modifications of histone tails represent an important. Selected epigenetic histone modifications together with variants of heterochromatin of histone deacetylases (HDACi) that have also an ability to induce...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 878 tis. Kč
    • •
  • 1 878 tis. Kč
    • •
  • GA ČR
Project

Characterization of telomer chromatin proteins (IAC5004111)

. Besides, characterization of telomeric chromatin, namely the acetylation state of its histones will be performed using immunochemical approaches. The outcomes of the project......

CE - Biochemie

  • 2001 - 2001
    • •
  • 344 tis. Kč
    • •
  • 207 tis. Kč
    • •
  • AV ČR
Project

Modification of histones in chromatin regions with increased and reduced expression (1K04112)

The variety of histone modifications (histone code) is believed to mark expression or silencing of genes. Clustering of active or silent genes in regions the histone-code hypothesis. The most important in this context are H...

EB - Genetika a molekulární biologie

  • 2004 - 2005
    • •
  • 448 tis. Kč
    • •
  • 238 tis. Kč
    • •
  • MŠMT
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