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6 (0,074s)

Project

Role of receptor tyrosine kinase Her2 in mitochondria (GA16-12719S)

The oncoprotein Her2 is overexpressed in up to 30% cancer patients. We found is for the receptor tyrosine kinase highly unexpected. The function of Her2 in mitochondria obvious that mitochondrial Her2 also increases express...

EB - Genetika a molekulární biologie

  • 2016 - 2018
  • 6 654 tis. Kč
  • 6 543 tis. Kč
  • GA ČR
Project

Bioconjugates of nanoparticles as new carriers of 223Ra for targeted alpha radiotherapy (8J20PL016)

in vitro on HER2 positive and HER2 negative cell cultures. Moreover, the further aim...

Inorganic and nuclear chemistry

  • 2020 - 2022
  • 201 tis. Kč
  • 201 tis. Kč
  • MŠMT
Project

Hematogeneous micrometastases from breast cancer and its significance for clinical outcome and possibilities of next treatment. (NT11404)

The blood samples of women with diagnosis of breast cancer will be immunocytochemicaly analyzed for circulating tumor cells. Frequency of CTC will be compared with different breast cancer stages and with basic prognostic factors (node involvement, tu...

FK - Gynekologie a porodnictví

  • 2010 - 2014
  • 5 791 tis. Kč
  • 5 791 tis. Kč
  • MZ
Project

Zinc signaling and metallothioneins sub/isoforms expression in breast cancer implications for prognostic and therapeutic purposes (GC19-13766J)

The project is focused on a detailed study of zinc-dependent signalization and its relation to expression of sub/isoforms of metallothioneins in selected subtypes of breast cancer. Research plan is a cooperation effort, connecting expertise of Prof. ...

Cell biology

  • 2019 - 2021
  • 5 339 tis. Kč
  • 5 339 tis. Kč
  • GA ČR
Project

Gene expression profiling in cancer circulating cells (CTCs) in breast carcinoma patients - a tool for early metastasis detection and therapy individualisation. (NS9976)

The main goal of the project is to monitor disease progress in breast cancer patient by measuring the expression of disease marker genes MUC-1, EpCAM, and HER2/neu in circulating tumor cells (CTCs). Based on the number of CTCs in blood circu...

EB - Genetika a molekulární biologie

  • 2008 - 2011
  • 4 644 tis. Kč
  • 4 637 tis. Kč
  • MZ
Project

Tumor activatable nanoprobes for highly precise fluorescence-guided surgery (NU21-08-00280)

of the tumor. To further increase tumor targeting, oligopeptides towards the EGF, Her2...

Otorhinolaryngology

  • 2021 - 2024
  • 16 219 tis. Kč
  • 16 219 tis. Kč
  • MZ
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