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18 (0,084s) •

Project

Analysis of clonal heterogeneity in chronic lymphocytic leukemia using next generation sequencing of B cell receptor. A national study. (NV15-30015A)

Chronic lymphocytic leukemia (CLL) is characterized by extraordinary heterogeneity concerning clinical presentation and molecular features. As the clonal disease of B lymphocytes, each case can be described by a specific immunoglobulin gene (IG) enco...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 15 351 tis. Kč
    • •
  • 15 028 tis. Kč
    • •
  • MZ
Project

Utilization of multispectral snaps and yield maps for technological processesmanagement in agriculture (RE5569)

GB - Zemědělské stroje a stavby

  • 1995 - 1995
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MZe
Project

Clonal expansions in chronic lymphocytic leukemia – (epi)genomic characterization towards better disease understanding (NW24-03-00052)

In the present project, we would like to study the ontogenesis of chronic lymphocytic leukemia (CLL) through the systematic examination of its multiclonal form. CLL is typically a monoclonal disorder. However, in our previous work, we have described ...

Oncology

  • 2024 - 2027
    • •
  • 15 347 tis. Kč
    • •
  • 15 347 tis. Kč
    • •
  • MZ
Project

Colobiome Tumour-adjacent microbiome and immune profile of tumour in the context of heterogeneity and aggressiveness of colorectal cancer (NV16-31966A)

Despite an enormous effort, the current molecular predictive and prognostic classifiers of colorectal cancer (CRC) are only marginally better than standard clinical risk factors. The reasons why lie in the tumour heterogeneity on one side and on inab...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 10 857 tis. Kč
    • •
  • 10 634 tis. Kč
    • •
  • MZ
Project

Modelling of heat and mass transfer in large systems of massive metal materials during solidification (GA106/08/0606)

The Project will endeavour to obtain new findings in the field of transfer phenomena during crystallization and cooling of massive metal systems. Mathematical models of heat and mass transfer during solidification will be established. A new original ...

JG - Hutnictví, kovové materiály

  • 2008 - 2011
    • •
  • 4 990 tis. Kč
    • •
  • 4 990 tis. Kč
    • •
  • GA ČR
Project

Selection of genomic defects in chronic lymphocytic leukemia and their impact on disease outcome (NV15-31834A)

In chronic lymphocytic leukemia (CLL), the absence of primary genomic defect implies that various circumstances, represented by both intrinsic and extrinsic factors, have to be met to support leukemic clone selection, growth and evolution. The variet...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 912 tis. Kč
    • •
  • 9 912 tis. Kč
    • •
  • MZ
Project

Cancer cell plasticity and tumor heterogeneity in relation to aggressiveness of prostate cancer and validation of selected prognostic factors (NV15-28628A)

The incidence of prostate cancer (PCa) is increasing worldwide. The outcome largely depends on early diagnosis and the identification of favorable prognostic biomarkers. Understanding of the cancer markers and prognostic factors in the context of pla...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 12 650 tis. Kč
    • •
  • 12 650 tis. Kč
    • •
  • MZ
Project

Analysis of tumor heterogeneity in advanced prostate cancer and novel approaches for therapy selection (NU20-03-00201)

Advanced prostate cancer temporarily respond to androgen deprivation therapy but tumors progress to castration-resistant stage (CRPC) with limited treatment options. First, we aim to study tumor heterogeneity of high-risk prostate cancer by multipara...

Oncology

  • 2020 - 2024
    • •
  • 13 560 tis. Kč
    • •
  • 13 488 tis. Kč
    • •
  • MZ
Project

Multiparametric single cell analysis of tumor cells and microenvironment in the triple-negative breast cancer (NV18-08-00245)

Triple-negative breast cancer (TNBC) is remarkably heterogeneous subtype of breast cancer, with relatively poor outcome due to aggressive clinical behavior and lack of characterized molecular targets for therapy. We will develop a technological platf...

Oncology

  • 2018 - 2021
    • •
  • 13 919 tis. Kč
    • •
  • 13 919 tis. Kč
    • •
  • MZ
Project

National study of leukemia cell mutations and clonality in patients diagnosed with acute myeloid leukemia (NV15-25809A)

Molecular analysis at diagnosis and following monitoring of specific gene aberrations represent a standard part of a diagnostic-therapeutic process, especially in cytogenetically normal acute myeloid leukemia (AML) patients. Besides the routinely tes...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 14 429 tis. Kč
    • •
  • 14 429 tis. Kč
    • •
  • MZ
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