All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

10 (0,072s) •

Project

Changes in the profile of steroids and their neuroactive metabolites in relation to prediction of term (NS9834)

The parturition is a multi-factorial process. A trigger mechanism that could be associated with the induction of parturition could be the changes of progesterone levels and, in human, particularly the changes of progesterone neuroactive metabolites. ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 5 646 tis. Kč
    • •
  • 5 646 tis. Kč
    • •
  • MZ
Project

Identification of amino acid residues of the HsdS and HsdR subunits required for correct assembly of Type I restriction-modification enzyme EcoR124I (GA204/07/0325)

and HsdS subunits involved in subunit assembly of the Type I restriction-modification(R-M) enzyme EcoR124I. The HsdS subunit plays a key role in the function of Type I- hydrolysis and subsequentDNA translocation. Since the HsdS...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 165 tis. Kč
    • •
  • 4 165 tis. Kč
    • •
  • GA ČR
Project

Metabolism of steroids in inflamatory bowel disease (NK6723)

Are there changes of activity and gene expresion of dehydrogenases 11 beta hydrosteroids 1 and 2 (11 HSD 1 and 11 HSD 2) in patients suffering from inflammatory bowel disease (Crohn´s disease and ulcerative colitis ?). Are there cha...

FE - Ostatní obory vnitřního lékařství

  • 2001 - 2003
    • •
  • 2 719 tis. Kč
    • •
  • 2 693 tis. Kč
    • •
  • MZ
Project

The importance of the enzyme 11beta-hydroxysteroid dehydrogenase type 1 in human obesity (NT13542)

The enzyme 11beta HSD 1 is involved in the processes of energy balance and food intake. We will investigate how the activity of the enzyme is changing before of 11beta HSD 1. Normostenic controls will be also investigated. For the a...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2014
    • •
  • 4 108 tis. Kč
    • •
  • 4 108 tis. Kč
    • •
  • MZ
Project

20alpha-hydroxy-metabolites of neuroactive pregnenolone isomers, progesterone and pregnenolone around parturition and the importace in physiology and diagnostics (NR9156)

The project investigates a possibility of influencing of the onset of parturition by changes in activity of 20alfa-hydroxysteroid dehydrogenase, which could contribute to the accelerating catabolism of progesterone and neuroinhibiting pregnanolone is...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 7 161 tis. Kč
    • •
  • 5 883 tis. Kč
    • •
  • MZ
Project

The role of peripheral metabolism of glucocorticoids in inflammation-induced changes in humans and animal model of inflammatory bowel disease (NR8576)

Tissue concentration of steroid metabolites will be measured in experimental models of IBD activity of 11 HSD will be estimated in tisue homogenates.Expression mRNA 11 HSD1 and mRNA 11 HSD2 will be estimated by RT-PCR Separation of immune ce...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2005 - 2007
    • •
  • 3 732 tis. Kč
    • •
  • 3 607 tis. Kč
    • •
  • MZ
Project

Amyloid ß peptides and mitochondrial enzyme 17ß-hydroxysteroid dehydrogenase type 10, possibility of Alzheimer disease diagnostics using optical biosensors (NR9322)

in the expression of HSD-10 in the brains of male Wistar and Long Evans rats occurring during...

FH - Neurologie, neurochirurgie, neurovědy

  • 2007 - 2009
    • •
  • 11 426 tis. Kč
    • •
  • 11 298 tis. Kč
    • •
  • MZ
Project

Analysis of mutants of type I restriction-modification enzymes altering subunit assembly (GA204/00/1251)

with these enzymes. Using a unique collection of mutants in the HsdS subunit we will investigate...

EE - Mikrobiologie, virologie

  • 2000 - 2002
    • •
  • 1 826 tis. Kč
    • •
  • 1 550 tis. Kč
    • •
  • GA ČR
Project

The role of oxidoreductases in the regulation of tissue-specific effect of steroids in birds (IAA6011201)

and endogenous inhibitors, (3) the role of 11 HSD and 20HSD in steroid regulation...

ED - Fyziologie

  • 2002 - 2006
    • •
  • 2 673 tis. Kč
    • •
  • 2 141 tis. Kč
    • •
  • AV ČR
Project

Development of DIANA-based in vitro ADME methods for new drug discovery (TJ02000276)

The aim of this project is the development and validation of in vitro ADME assays based on DIANA technology, surpassing the conventional methods in terms of speed, accuracy and cost-efficiency, and subsequent in vitro ADME characterization of novel G...

Pharmacology and pharmacy

  • 2019 - 2021
    • •
  • 8 787 tis. Kč
    • •
  • 7 213 tis. Kč
    • •
  • TA ČR
  • 1 - 10 out of 10