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4 878 (0,086s) •

Project

The transcription factor C/EBPg as a novel regulator in mast cell development and function (GA18-08577S)

Mast cells contribute to the activities of innate and adaptive branches properties are in contrast to the contribution of mast cells to certain pathologies. Thorough knowledge of mast cell biology...

Human genetics

  • 2018 - 2022
    • •
  • 6 987 tis. Kč
    • •
  • 5 793 tis. Kč
    • •
  • GA ČR
Project

Microtubules in activated mast cells - targets for innovative therapies (LD13015)

The aims othis project are: 1. To identify composition and function of complexes containing tubulins and signalling molecules in activated mast cells. 2. To characterize gamma-tubulin interactions with phosphoinositide-3-kinase and ...

EC - Imunologie

  • 2013 - 2014
    • •
  • 942 tis. Kč
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  • 942 tis. Kč
    • •
  • MŠMT
Project

Membrane signalosomes of mast cells and basophils - targets for innovative therapies (LD12073)

of the FceRI membrane signalosomes important for antigen-induced degranulation in mast cells. 2. To contribute to determining the composition of membrane signalosomes important for antigen-induced adhesion and chemotaxis in mas...

EC - Imunologie

  • 2012 - 2014
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • MŠMT
Project

Signaling pathways involved in mast cell chemotaxis (GA14-09807S)

Chemotaxis of mast cells is an important biological process leading and acquired immunity. Plasma membrane of mast cells possesses a wide array of surface a sphingosine 1-phosphate. Using mouse mast ce...

EC - Imunologie

  • 2014 - 2016
    • •
  • 7 035 tis. Kč
    • •
  • 7 035 tis. Kč
    • •
  • GA ČR
Project

Regulatory roles of the cytoskeletal protein 4.1R in mast cell activation (GA17-20255S)

. In this project we will examine function of 4.1R in mast cell activation. We will compare properties of mast cells obtained from mice with 4.1R gene knockout (4.1R-KO) or control cells. Project will incl...

EC - Imunologie

  • 2017 - 2019
    • •
  • 7 962 tis. Kč
    • •
  • 7 494 tis. Kč
    • •
  • GA ČR
Project

The role of tetraspanin CD53 in mast cell biology (GA20-16481S)

of tetraspanin CD9 in mast cell activation and chemotaxis and in this project we will focus on tetraspanin CD53 whose role in mast cell signaling is unknown. As a model we will use mast in mouse mast<...

Immunology

  • 2020 - 2022
    • •
  • 8 842 tis. Kč
    • •
  • 8 647 tis. Kč
    • •
  • GA ČR
Project

Transgenic rats for analysis of expresion and function of Thy-1 glycoprotein in rat mast cells (GA301/96/0897)

Rat mast cells, a widely used model for analysis of anaphylaxis, express in cell activation. Thy-1 is however not expressed in mouse mast cells indicating the role of these elements in species-specific Thy...

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 2 973 tis. Kč
    • •
  • 2 397 tis. Kč
    • •
  • GA ČR
Project

Regulatory roles of LAIR-1 (CD305) in mast cell physiology and mastocytosis (GA24-12572S)

Mast cells are immune cells with multifaceted functions during homeostasis and activating receptors governs mast cell responsiveness to various stimuli. Recently we found that mast cells ...

Immunology

  • 2024 - 2026
    • •
  • 10 476 tis. Kč
    • •
  • 9 891 tis. Kč
    • •
  • GA ČR
Project

Calcium signaling to microtubules in activated mast cells (GA16-25159S)

Mast cells play a pivotal role in innate immunity, allergy and inflammation. Antigen-induced activation of mast cells leads to rapid cytoskeleton rearrangement during activation events. Using mouse mast

EA - Morfologické obory a cytologie

  • 2016 - 2018
    • •
  • 6 075 tis. Kč
    • •
  • 5 781 tis. Kč
    • •
  • GA ČR
Project

New signaling pathways induced in mast cells by cholesterol-dependent cytolysins (GA23-07736S)

Mast cells are sensitive immune sensors of the tissue microenvironment. Within preliminary data, that CDCs at sublytic concentrations activate mast cells by mechanisms, to determine the mechanisms of CDC-mediated a...

Immunology

  • 2023 - 2025
    • •
  • 9 951 tis. Kč
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  • 9 657 tis. Kč
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  • GA ČR
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