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6 (0,051s) •

Project

The role of cellular prion protein (PrPc) expression on blood cells (GA310/04/0419)

(PrPc) on blood platelets and/or red blood cells (RBC). We hypothesize that PrPc transplantation for creation of mouse chimeras expressing different levels of PrPc on blood......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2004 - 2006
    • •
  • 4 326 tis. Kč
    • •
  • 3 862 tis. Kč
    • •
  • GA ČR
Project

Cell culture for propagation of prions influence of cell culture proliferation and expression of endogenous retroviruses (GP310/09/P260)

or prion diseases, is the misfolding of cellular prion protein - PrPc into infectious isoform - PrPtse. Little is known about physiological function of PrPc and also processes of conformational changes from PrPc to the PrP...

EE - Mikrobiologie, virologie

  • 2009 - 2011
    • •
  • 1 629 tis. Kč
    • •
  • 1 629 tis. Kč
    • •
  • GA ČR
Project

Detection of prion protein in blood and cerebral spinal fluid of patients with Creutzfeldt-Jakob disease (NS10335)

amount of cellular prion protein (PrPc) and by unavailability of PrPtse specific antibodies.Recently, a small number of antibodies that can discriminate between PrPc and PrPtse multi-color flow cytometry to study PrPc / Pr...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2009 - 2011
    • •
  • 5 116 tis. Kč
    • •
  • 5 116 tis. Kč
    • •
  • MZ
Project

The presence of Prion and Cellular Prion Protein in Blood Optimalization of Detection Methods (NI7416)

The project objective is characterization of cellular prion protein present in different components of blood and utilization of this kowledge in a selection of strategies for optimal detection of infectious prion in tblood. The results will contribut...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
    • •
  • 1 649 tis. Kč
    • •
  • 1 649 tis. Kč
    • •
  • MZ
Project

Development and Utilization of Anti- Prion Monoclonal Antibodies for Detection of PrPtse/PrPc in Cell Cultures and Blood (MEB091004)

1. Utilize different anti-PrP mAbs, developed by the Slovene partner for the detection of different strains of PrPtse in prion infected mouse cell cultures of neuronal or fibroblast origin in different stages of cell division provided by #ORIGch part...

EE - Mikrobiologie, virologie

  • 2010 - 2011
    • •
  • 112 tis. Kč
    • •
  • 112 tis. Kč
    • •
  • MŠMT
Project

New diagnostic approaches to Creutzfeldt-Jakob disease (NT14145)

The proposed project aims to implement new diagnostic criteria and biomarkers in CJD into current practice leading to a more precise diagnosis of CJD at early stages. The project will enhance our knowledge about PrPc/PrPtse expression in blo...

FH - Neurologie, neurochirurgie, neurovědy

  • 2013 - 2015
    • •
  • 5 713 tis. Kč
    • •
  • 5 713 tis. Kč
    • •
  • MZ
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