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6 752 (0,08s) •

Project

Complexes of selected transition metals with plant-derived compounds with anti-NF-kappa B and pro-PPAR dual activities (GF21-38204L)

Diseases associated with chronic inflammation are still a major medical problem.Promising approach to manage inflammatory processes is the modulation of activity of pro-inflammatory transcription factor NFκB and simultaneous activation of an...

Inorganic and nuclear chemistry

  • 2021 - 2023
    • •
  • 9 028 tis. Kč
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  • 9 028 tis. Kč
    • •
  • GA ČR
Project

Signalling pathways in myeloma bone disease (NT14393)

The aim of the project is to improve diagnostics and monitoring of myeloma bone disease with specification of the indications of anti-resorption therapy. For the assessment of convenient cytokines and chemokines we will use accessible biological mate...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 3 036 tis. Kč
    • •
  • 3 036 tis. Kč
    • •
  • MZ
Project

Effect of pro- and anti-inflammatory factors on cytochrome P450 expression - modulation by natural substances (GP303/04/P074)

signalling pathways or other transcription factors, namely nuclear factor kappa beta...

CE - Biochemie

  • 2004 - 2006
    • •
  • 672 tis. Kč
    • •
  • 672 tis. Kč
    • •
  • GA ČR
Project

Compactness principles and combinatorics (GF19-29633L)

The project will investigate the effect of compactness principles on the structure of the generalized Cantor space 2^kappa, where kappa is an infinite regular cardinal. The focus of the project will be on two compactness principles:...

Pure mathematics

  • 2019 - 2022
    • •
  • 4 768 tis. Kč
    • •
  • 4 768 tis. Kč
    • •
  • GA ČR
Project

Nuclear Factor-kappaB and radiotherapy in colorectal cancer (NR8053)

radiation and NF-?B activation will be measured. The role of radiation in NF-?B activation in colon cancer cell lines will be assessed. We will seek inhibitors of NF-?B. In addition, NF-?B activation will be evalu...

FJ - Chirurgie včetně transplantologie

  • 2004 - 2006
    • •
  • 3 402 tis. Kč
    • •
  • 3 391 tis. Kč
    • •
  • MZ
Project

Increasing of exportation by providing the development of modernized airplane KAPPA 2 and by making the batch production of UL airplanes KAPPA more progressive. (FA-E2/029)

The KAPPA 2 is very light aircraft with reasonable price. The aircraft will overtake the world-wide competition and will be on the top among of the comparable aircrafts for it´s shape construction and workshop processing.......

JU - Aeronautika, aerodynamika, letadla

  • 1999 - 2001
    • •
  • 37 058 tis. Kč
    • •
  • 17 500 tis. Kč
    • •
  • MPO
Project

Modulation of innate immune response by probiotic bacteria (GA523/07/0572)

inflammatory factors: transcription factor NF-kappa B, interleukins 1beta, 8 and 10, tumour necrosis factor alpha and NO/oxygen reactive metabolites. The relation between with enteropathogenic Escherichia...

EC - Imunologie

  • 2007 - 2011
    • •
  • 6 696 tis. Kč
    • •
  • 6 696 tis. Kč
    • •
  • GA ČR
Project

Inhibition of metastatic spread via impact on components of plasminogen activator (KJB501070501)

. Consequently PPAR? receptors are activated and the activity of NF-kappa-B transcription factor is modulated, thus the expression of proinflammatory cytokines......

FD - Onkologie a hematologie

  • 2005 - 2007
    • •
  • 1 155 tis. Kč
    • •
  • 1 155 tis. Kč
    • •
  • AV ČR
Project

Spatial organisation of key nuclear domains and their protein components (LTC18048)

a) To determine the distribution of replication and transcription in the nucleolar subdomains b) To analyse distribution of histone variants in the nucleolar DNA fraction c) To create an interaction network of histone chaperones and select...

Plant sciences, botany

  • 2018 - 2021
    • •
  • 3 430 tis. Kč
    • •
  • 3 430 tis. Kč
    • •
  • MŠMT
Project

Modeling and observable features of non-equilibrium processes in the solar spectra (GA22-07155S)

kappa distributions of electrons, as well as non-equilibrium ionization, and their influence on the optically thin line spectra. Spectra for the kappa-distributions or the other types of distributions will be modelled using either ...

Astronomy (including astrophysics,space science)

  • 2022 - 2024
    • •
  • 6 049 tis. Kč
    • •
  • 6 049 tis. Kč
    • •
  • GA ČR
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