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19 (0,098s) •

Project

Clonal expansions in chronic lymphocytic leukemia – (epi)genomic characterization towards better disease understanding (NW24-03-00052)

In the present project, we would like to study the ontogenesis of chronic lymphocytic leukemia (CLL) through the systematic examination of its multiclonal form. CLL is typically a monoclonal disorder. However, in our previous work, we have described ...

Oncology

  • 2024 - 2027
    • •
  • 15 347 tis. Kč
    • •
  • 15 347 tis. Kč
    • •
  • MZ
Project

Selection of genomic defects in chronic lymphocytic leukemia and their impact on disease outcome (NV15-31834A)

In chronic lymphocytic leukemia (CLL), the absence of primary genomic defect implies that various circumstances, represented by both intrinsic and extrinsic factors, have to be met to support leukemic clone selection, growth and evolution. The variet...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 912 tis. Kč
    • •
  • 9 912 tis. Kč
    • •
  • MZ
Project

National study of leukemia cell mutations and clonality in patients diagnosed with acute myeloid leukemia (NV15-25809A)

Molecular analysis at diagnosis and following monitoring of specific gene aberrations represent a standard part of a diagnostic-therapeutic process, especially in cytogenetically normal acute myeloid leukemia (AML) patients. Besides the routinely tes...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 14 429 tis. Kč
    • •
  • 14 429 tis. Kč
    • •
  • MZ
Project

Comprehensive prognostic and predictive panel for chronic lymphocytic leukemia a next-generation sequencing tool suitable for clinical practice and study of genetic architecture behind the disease evolution (NV19-03-00091)

Chronic lymphocytic leukemia (CLL) is common and still incurable leukemia of adults characterized by remarkable genetic and clinical heterogeneity. In the proposed project, we aim to study genetic background of clonal evolution in treatment naive CLL...

Oncology

  • 2019 - 2022
    • •
  • 14 426 tis. Kč
    • •
  • 14 426 tis. Kč
    • •
  • MZ
Project

Single cell analysis a modern tool to study clonal evolution in high-risk patients with chronic lymphocytic leukemia (NU20-08-00314)

The proposed project builds on our continuous well-established research on chronic lymphocytic leukemia (CLL). In this study, we would like to profound our knowledge to better understand the mechanisms underlying clonal evolution of CLL cells during ...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2020 - 2023
    • •
  • 11 736 tis. Kč
    • •
  • 11 736 tis. Kč
    • •
  • MZ
Project

Advanced sequencing methods for deciphering structural variants in cancer genome (NU21-08-00237)

Complex karyotypes (CK), containing dicentric chromosomes (DC) and/or chromothripsis (cth) are frequent findings present in cancer cells, which denote unfavorable prognosis of patients. However, their detection using standard methods of classical and...

Human genetics

  • 2021 - 2025
    • •
  • 12 671 tis. Kč
    • •
  • 12 671 tis. Kč
    • •
  • MZ
Project

Evolution of mucosal antimicrobial immunity (GA206/07/0378)

Mucosal surfaces represent important entrance gateway for infection and it is supposed that majority of pathogenic microorganisms enter the body through mucosae, where they have to overcome efficient immune mechaisms. The proposed project is focused ...

EG - Zoologie

  • 2007 - 2011
    • •
  • 5 427 tis. Kč
    • •
  • 5 427 tis. Kč
    • •
  • GA ČR
Project

Center of Biocatalysis and Biotransformation (LC06010)

The aim of the project is to develop and optimize novel biocatalysts (dehalogenases, esterases, nitrilases, amidases, glycosidases etc.), to study their molecular structure and biocatalysis mechanisms and to introduce methods for their structure-func...

CE - Biochemie

  • 2006 - 2011
    • •
  • 69 815 tis. Kč
    • •
  • 69 708 tis. Kč
    • •
  • MŠMT
Project

Horizontal gene transfer in plants (GA521/08/0932)

Horizontal gene transfer is generally considered as a wide-spread phenomenon and an important evolutionary factor in bacteria. In eukaryotes, the horizontal gene transfer is much less frequent. Several cases of horizontal gene transfer in eukaryotes ...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 3 993 tis. Kč
    • •
  • 3 993 tis. Kč
    • •
  • GA ČR
Project

Evolution of nest cleptoparasitism in bees based on the model group of the genus Sphecodes (Insecta Hymenoptera, Halictidae) (GA206/09/0522)

The proposed project has the main aim to clarify some important aspects of nest cleptoparasite phylogeny and behaviour. European Sphecodes species will be used as a good sample for our surveys. All types of specialization both of individuals and spec...

EG - Zoologie

  • 2009 - 2011
    • •
  • 1 076 tis. Kč
    • •
  • 1 076 tis. Kč
    • •
  • GA ČR
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