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124 (0,103s) •

Project

Functional characterization of aberrant ERG in hematopoiesis and leukemia (GJ15-06049Y)

. One of the recurrent aberrations in childhood ALL are intragenic deletions of the ERG gene. We have shown that the deletions occur in approximately 5% of pediatric and a favorable prognosis. ALL carrying ERG deletions are...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 7 418 tis. Kč
    • •
  • 7 418 tis. Kč
    • •
  • GA ČR
Project

Significance of chromosomal deletions in preulekemias and leukemias (NC6675)

Detection of breakpoints and deleted chromosomal regions in patients with hematological malignancies using molecular cytogenetic methods. Comparing the difference in quantitative number of aberrant clones in mitoses and interphase nuclei.......

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 2 058 tis. Kč
    • •
  • 1 973 tis. Kč
    • •
  • MZ
Project

Amplification of mycooncogenes and deletion of some suppressor genes in lung tumors. (IZ2291)

FD - Onkologie a hematologie

  • 1994 - 1997
    • •
  • 1 555 tis. Kč
    • •
  • 2 040 tis. Kč
    • •
  • MZ
Project

The impact of gene conversions and deletions of P450c21B on enzyme activity and phenotype. (IZ2897)

FG - Pediatrie

  • 1995 - 1997
    • •
  • 504 tis. Kč
    • •
  • 504 tis. Kč
    • •
  • MZ
Project

The role of Toll-like receptor signaling in the mechanism of central tolerance (GA19-23154S)

the selfreactive repertoire within the T cell population via deletion of T cells that express mTECs to DCs is a prerequisite for efficient deletional tolerance and Treg selection on the establishment of deletional toleranc...

Immunology

  • 2019 - 2021
    • •
  • 8 619 tis. Kč
    • •
  • 8 178 tis. Kč
    • •
  • GA ČR
Project

Molecular and Cytogenetic Characterization of the Chromosome-5 long arm deletion ( del (5q) ) in patients with MDSand AML. (IZ2826)

FD - Onkologie a hematologie

  • 1995 - 1997
    • •
  • 2 285 tis. Kč
    • •
  • 2 285 tis. Kč
    • •
  • MZ
Project

Molecular aspects of diagnostics and therapy of spinal muscular atrophy (1A8608)

Spinal muscular atrophy is autosomal-recessive disease caused in ca. 95% of cases by homozygous deletion of the SMN1 gene. The SMN1 gene and its SMN2 copy in about 70%, while about the same fraction of SMN2 products shows deletion o...

FH - Neurologie, neurochirurgie, neurovědy

  • 2005 - 2008
    • •
  • 4 414 tis. Kč
    • •
  • 4 335 tis. Kč
    • •
  • MZ
Project

Gene targeting in chicken and the resistance to newly emerging retroviruses (GA15-23993S)

into the cells of susceptible species (chicken and turkey) and deletions or substitutions with deletion of W38 using the CRISPR/Cas9n–mediated homologous recombination. The same with the aim to create inbred chicken line bearing

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 7 303 tis. Kč
    • •
  • 7 010 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial disorders with instability of mitochondrial DNA (NV17-30965A)

) and nuclear genome. Subgroup of MD is characterized by mtDNA instability. MtDNA deletions novel factors responsible for presence of deleted mtDNA molecules found in patient......

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 13 003 tis. Kč
    • •
  • 12 960 tis. Kč
    • •
  • MZ
Project

ACE gene polymorphism and smoking addiction (NJ7324)

To evaluate a possible association between an insertion/deletion polymorphism in the ACE gene and the numbers of cigarettes smoked by individuals in a large population based study.......

FP - Ostatní lékařské obory

  • 2002 - 2003
    • •
  • 1 534 tis. Kč
    • •
  • 1 534 tis. Kč
    • •
  • MZ
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