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1 083 (0,156s) •

Project

Calcium signaling in neonatal rat gonadotrophs (IAA5011105)

the roleof ryanodine receptor and protein kinase C, the mechanism of melatonin action receptor coupled to G protein which stimulates oscillatory calcium release from......

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 2 917 tis. Kč
    • •
  • 848 tis. Kč
    • •
  • AV ČR
Project

Mutations of ryanodine receptor in relationship to malignant arrhythmias and sudden cardiac death in patients with heart failure (2B08061)

The aim of the project is to contribute to better understanding of sudden cardiac death pathophysiology. The study population will consist of high risk patients with heart failure who survived malignant ventricular arrhythmia. In these individuals oc...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2008 - 2011
    • •
  • 7 594 tis. Kč
    • •
  • 6 651 tis. Kč
    • •
  • MŠMT
Project

Modeling DMD-related dilated cardiomyopathy using induced pluripotent stem cells-derived cardiomyocytes (GA13-19910S)

Duchenne Muscular Dystrophy (DMD) is a X-linked disorder caused by the lack of dystrophin at the sarcolemma due to nonsense mutations. Recent studies have suggested that absence of dystrophin may alter the intracellular calcium (Ca) handling in cardi...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
    • •
  • 6 415 tis. Kč
    • •
  • 6 415 tis. Kč
    • •
  • GA ČR
Project

Activation of pig oocytes - the role of inositol trisphosphate receptors, ryanodine receptors, calmodulin and protein kinase C (GA524/99/0301)

The aim of this study is to investigate the processes involved in the regulation of the exit of pig oocytes from the meiotic metaphase II stage. The aims of this study are to test the following hypotheses: 1) If the two-storey model for Ca2+ release ...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 1999 - 2001
    • •
  • 1 087 tis. Kč
    • •
  • 1 087 tis. Kč
    • •
  • GA ČR
Project

Evaluation of ion channels and receptors in human neural progenitors derived from induced pluripotent stem cells during motoneuronal differentiation (GA17-21146S)

of ion channels and receptors in SCs is not fully understood. Our preliminary data neural cells, affects expression of ion channel and receptors which could play of ion channels, receptors and Ca2+ homeostatic and signalin...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2018
    • •
  • 2 755 tis. Kč
    • •
  • 2 608 tis. Kč
    • •
  • GA ČR
Project

The molecular mechanism of the depletion of cardiomyocyte progenitors in dystrophinopathy (7AMB16FR015)

Aim 1: Generate the human induced pluripotent stem cells from patients suffering the Duchenne muscular dystrophy and differentiate the hiPS cells to mature cardiomyocytes. Aim 2: Determine the level of fibrosis, amount of progenitors and their clonog...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2016 - 2017
    • •
  • 108 tis. Kč
    • •
  • 108 tis. Kč
    • •
  • MŠMT
Project

Cellular a molecular physiology of cardiomyocytes (MEB0810151)

An insight into cardiomyocytes function and mechanisms of its disorder in cardiovascular diseases is the essential pre-requisite for targeted therapy. The objective of the project is to elucidate further the relations between signaling and energetic ...

ED - Fyziologie

  • 2010 - 2011
    • •
  • 114 tis. Kč
    • •
  • 114 tis. Kč
    • •
  • MŠMT
Project

Influence of thyroid hormones on expression of myofibrillar and Ca2+ transporting proteins (GA304/05/0327)

isoforms, sarcoplasmic reticulum Ca2+-ATPase, Na+/Ca2+ exchanger, ryanodine and inositol 1,4,5-triphosphate receptors will be studied. Proteins will be assessed by gel......

EA - Morfologické obory a cytologie

  • 2005 - 2007
    • •
  • 2 528 tis. Kč
    • •
  • 2 528 tis. Kč
    • •
  • GA ČR
Project

Reprogramming of DMD-patient cells into cardiomyocytes - insights into molecular pathology of dilated cardiomyopathy (7AMB13FR011)

Aim 1: Induce hCMs harboring DMD-linked mutations from patient biopsies via hiPS and investigate the Ca-related molecular mechanisms. This aim 1 will allow us not only to test whether the culture of hiPS-derived CMs from DMD patient biopsies is a sui...

EB - Genetika a molekulární biologie

  • 2013 - 2014
    • •
  • 108 tis. Kč
    • •
  • 108 tis. Kč
    • •
  • MŠMT
Project

Influence of allosteric modulators on specificity of coupling with G-proteins and desensitization of muscarinic receptors (GA305/05/0452)

In spite of preferential coupling of muscarinic receptors to distinct classes modulators that bind at secondary domains on the receptor not only influence receptor affinity for orthosteric ligands but also partially activat...

ED - Fyziologie

  • 2005 - 2007
    • •
  • 4 992 tis. Kč
    • •
  • 4 992 tis. Kč
    • •
  • GA ČR
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