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119 (0,055s) •

Project

Emergency granulopoiesis at the level of hematopoietic stem and progenitor cells The role of population dynamics and Wnt/β-catenin signaling (GA22-18300S)

Emergency granulopoiesis (EG) is responsible for enhanced granulocytic production during acute infection. Despite numerous studies demonstrating that hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) respond directl...

Immunology

  • 2022 - 2024
    • •
  • 8 676 tis. Kč
    • •
  • 8 544 tis. Kč
    • •
  • GA ČR
Project

Role of hypoxia-inducible factor 1 alpha in development of neural stem cell population in mouse (GJ15-13443Y)

Neural stem cells (NSC) are multipotent progenitors that give rise to neurons, glia cells or astrocytes in mammalian brain. NSC occupy specific region in neural tissue called niche which seems to keep them in self-renewing/multi...

ED - Fyziologie

  • 2015 - 2019
    • •
  • 4 285 tis. Kč
    • •
  • 4 285 tis. Kč
    • •
  • GA ČR
Project

Molecular bases of clonal heterogeneity and progression of polycythemia vera (GJ15-18046Y)

Polycythemia vera (PV) is an acquired clonal hematopoietic disorder arising from a multipotent hematopoietic stem cell, characterized by the JAK2 V617F somatic of JAK2 V617F-negative erythroid progenitors results from activation of ...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 4 500 tis. Kč
    • •
  • 4 500 tis. Kč
    • •
  • GA ČR
Project

Radiosenzitivity of hematopoietic progenitors (CD34+/AC133+) and effect of citokines on expansion ex vivo. (MO66020398129)

Radiosenzitivity of hematopoietic progenitors (CD34+/AC133+) and effect of citokines on expansion ex vivo....

FD - Onkologie a hematologie

  • 1998 - 2000
    • •
  • 643 tis. Kč
    • •
  • 643 tis. Kč
    • •
  • MO
Project

Deciphering self-renewing mechanisms in activated hematopoietic progenitors. (GA17-01897S)

progenitors. Early after damage, the number of Sca-1-CD71+ late progenitors rapidly this switch by activating in progenitors the mechanisms own otherwise to stem cells of the hematopoietic tissue regeneration by providing ...

FD - Onkologie a hematologie

  • 2017 - 2020
    • •
  • 9 735 tis. Kč
    • •
  • 9 360 tis. Kč
    • •
  • GA ČR
Project

New regulators of megakaryocyte and erythroid lineage commitment (GAP305/10/0953)

Differentiation of hematopoietic stem cells and progenitors into various and erythroid cells develop from a common myeloid progenitor which differentiates mechanism of cell commitment of the common megakaryocytic and erythroid p...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 5 167 tis. Kč
    • •
  • 5 167 tis. Kč
    • •
  • GA ČR
Project

Immunological properties of human progenitor cells and their clinical utilization (NI7540)

Detection od chemokine receptors on the human progenitor cells. ( CD34+) Study of the expression of chemokine receptors on normal and pathological cells and their importance in the immunology, pathogenesis and pathophysiology of blood diseas...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
    • •
  • 3 741 tis. Kč
    • •
  • 3 561 tis. Kč
    • •
  • MZ
Project

Ontogenetic Development of Functions, Phenotype and Gene Expression in Immune Cells and Their Progenitors (GA310/94/1879)

9H - 9

  • 1994 - 1996
    • •
  • 897 tis. Kč
    • •
  • 1 294 tis. Kč
    • •
  • GA ČR
Project

The molecular mechanism of the depletion of cardiomyocyte progenitors in dystrophinopathy (7AMB16FR015)

Aim 1: Generate the human induced pluripotent stem cells from patients suffering the Duchenne muscular dystrophy and differentiate the hiPS cells to mature cardiomyocytes. Aim 2: Determine the level of fibrosis, amount of progenitors 3: Dete...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2016 - 2017
    • •
  • 108 tis. Kč
    • •
  • 108 tis. Kč
    • •
  • MŠMT
Project

Cellular Aging in haematological malignancy (NT14310)

Age-conditioned alteration of mRNA and miRNA expression will be determined by whole genome assay for B cell progenitors in young and old healthy donors. The aging-biomarkers for B cell progenitors will be identified. B cell aging-di...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 8 570 tis. Kč
    • •
  • 8 511 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 119