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10 (0,092s) •

Project

Utilization of multispectral snaps and yield maps for technological processesmanagement in agriculture (RE5569)

GB - Zemědělské stroje a stavby

  • 1995 - 1995
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MZe
Project

Colobiome Tumour-adjacent microbiome and immune profile of tumour in the context of heterogeneity and aggressiveness of colorectal cancer (NV16-31966A)

Despite an enormous effort, the current molecular predictive and prognostic classifiers of colorectal cancer (CRC) are only marginally better than standard clinical risk factors. The reasons why lie in the tumour heterogeneity on one side and on inab...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 10 857 tis. Kč
    • •
  • 10 634 tis. Kč
    • •
  • MZ
Project

Modelling of heat and mass transfer in large systems of massive metal materials during solidification (GA106/08/0606)

The Project will endeavour to obtain new findings in the field of transfer phenomena during crystallization and cooling of massive metal systems. Mathematical models of heat and mass transfer during solidification will be established. A new original ...

JG - Hutnictví, kovové materiály

  • 2008 - 2011
    • •
  • 4 990 tis. Kč
    • •
  • 4 990 tis. Kč
    • •
  • GA ČR
Project

Analysis of clonal heterogeneity in chronic lymphocytic leukemia using next generation sequencing of B cell receptor. A national study. (NV15-30015A)

Chronic lymphocytic leukemia (CLL) is characterized by extraordinary heterogeneity concerning clinical presentation and molecular features. As the clonal disease of B lymphocytes, each case can be described by a specific immunoglobulin gene (IG) enco...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 15 351 tis. Kč
    • •
  • 15 028 tis. Kč
    • •
  • MZ
Project

Cancer cell plasticity and tumor heterogeneity in relation to aggressiveness of prostate cancer and validation of selected prognostic factors (NV15-28628A)

The incidence of prostate cancer (PCa) is increasing worldwide. The outcome largely depends on early diagnosis and the identification of favorable prognostic biomarkers. Understanding of the cancer markers and prognostic factors in the context of pla...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 12 650 tis. Kč
    • •
  • 12 650 tis. Kč
    • •
  • MZ
Project

Analysis of tumor heterogeneity in advanced prostate cancer and novel approaches for therapy selection (NU20-03-00201)

Advanced prostate cancer temporarily respond to androgen deprivation therapy but tumors progress to castration-resistant stage (CRPC) with limited treatment options. First, we aim to study tumor heterogeneity of high-risk prostate cancer by multipara...

Oncology

  • 2020 - 2024
    • •
  • 13 560 tis. Kč
    • •
  • 13 488 tis. Kč
    • •
  • MZ
Project

Multiparametric single cell analysis of tumor cells and microenvironment in the triple-negative breast cancer (NV18-08-00245)

Triple-negative breast cancer (TNBC) is remarkably heterogeneous subtype of breast cancer, with relatively poor outcome due to aggressive clinical behavior and lack of characterized molecular targets for therapy. We will develop a technological platf...

Oncology

  • 2018 - 2021
    • •
  • 13 919 tis. Kč
    • •
  • 13 919 tis. Kč
    • •
  • MZ
Project

Clinical implications of intra-tumour heterogeneity in colon cancer (NV19-03-00298)

Colorectal cancer (CRC) is the second most common cancer in Czech Republic and one of the leading causes of death. Despite recent advances, the recognition of high risk cases in early stages and the identification of the effective drug regimen remain...

Oncology

  • 2019 - 2023
    • •
  • 13 401 tis. Kč
    • •
  • 13 401 tis. Kč
    • •
  • MZ
Project

Tetraspanins in Prostate Cancer Decoding Clinical Significance through Integration of Single Cell Analysis, Tumor Heterogeneity, and Tumor Microenvironment Interactions (NW24-03-00265)

Prostate cancer is a pressing issue that necessitates the development of improved therapies. Tetraspanins, a type of transmembrane proteins, have shown potential in regulating cancer progression. Therefore, the primary objective of this study is to c...

Oncology

  • 2024 - 2027
    • •
  • 12 633 tis. Kč
    • •
  • 12 633 tis. Kč
    • •
  • MZ
Project

Targeting genomic diversity in primary and recurrent gliomas for further understanding of brain tumor pathogenesis. (NU21-04-00100)

Diffuse gliomas are the most common primary brain tumors in adults with specific histological and genetic features. They comprise a heterogeneous group of tumors that differ in malignant potential and therapy response. The treatment of gliomas is dif...

Oncology

  • 2021 - 2025
    • •
  • 13 243 tis. Kč
    • •
  • 13 193 tis. Kč
    • •
  • MZ
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