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26 (0,126s)

Project

Using 13C and proton MR spectroscopy to study the role of fatty acid transport and accumulation in tissues in the pathogenesis of insulin resistance (GAP301/11/2418)

expression of C-reactive protein, c) SHR rats with increased expression of SREBP-1a...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2011 - 2014
  • 5 272 tis. Kč
  • 5 272 tis. Kč
  • GA ČR
Project

The role of resistin and trascription factor SREBP-1 in the pathogenesis of insulin resistance. (NB7403)

rat strain and in the transgenic SHR rats overexpressing a SREBP-1 and resistin, the role and metabolic consequences of SREBP-1 and resistin will be analysed......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
  • 4 282 tis. Kč
  • 4 221 tis. Kč
  • MZ
Project

Effect of insulin and free fatty acids on the production of selected cytokines in adipose tissue in type 2 diabetic patients and healthy subjects. (NB7517)

The aim of the study is to test the effect of in vivo induced hyperinsulinemia/ or elevation of free fatty acids on expression of adiponectin, resistin, leptin, TNFalfa and SREBP-1 in subcutaneous adipose tissue in patients with type 2 diabe...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
  • 4 929 tis. Kč
  • 4 694 tis. Kč
  • MZ
Project

Structural and functional analysis of interaction between calmodulin and plectin isoform 1a (7AMB13AT012)

isoform 1a and to provide the model with a functional-structural basis. Following-terminal domain of plectin isoform 1a (1aABD) - structural analysis of the interaction between calmodulin and N-terminal domain of plectin isoform

EB - Genetika a molekulární biologie

  • 2013 - 2014
  • 170 tis. Kč
  • 170 tis. Kč
  • MŠMT
Project

Active participation on meeting of Technical Committee ICG/TC 1A Information and Communication - Pool of Glass Abstracts (PG97214)

JH - Keramika, žáruvzdorné materiály a skla

  • 1997 - 1997
  • 34 tis. Kč
  • 17 tis. Kč
  • MŠMT
Project

Active participation on meeting of Technical Committee ICG/TC 1A Information and Communication - Pool of Glass Abstracts (LA 024)

Projekt ukončen v r. 1998, angl. anotace není k dispozici...

JH - Keramika, žáruvzdorné materiály a skla

  • 1998 - 1998
  • 106 tis. Kč
  • 106 tis. Kč
  • MŠMT
Project

Sustainable development of rural areas. stability of rural settlement and planning- significant conditions of sustainable development of rural areas (GA205/97/0081)

The applicants concentrate to two connected problems - stability of rural settlement (1) and the regional planning of rural areas (2). They want in (1) to analyze development of rural settlement in the Czech Republic (1a). They would like to...

AO - Sociologie, demografie

  • 1997 - 1999
  • 1 003 tis. Kč
  • 918 tis. Kč
  • GA ČR
Project

Charcot - Marie - Tooth 1 and HNPP - investigation in pacients and families using DNA microsatellite STR markers from region 17p.11.2 - p12. (NM3)

Investigation of families with Hereditary Sensomotoric Neuropathy Charcot-Marie-Tooth 1A and HNPP using microsatellite dinucleotide DNA markers, identifying submicroscopic duplications and deletions in region 17p11.2-p12.......

FH - Neurologie, neurochirurgie, neurovědy

  • 1998 - 2000
  • 1 344 tis. Kč
  • 1 262 tis. Kč
  • MZ
Project

Role of monocyte metabolism and transcription factor networks in progression of human sepsis. (NV18-06-00529)

The host immune system plays a critical role in the development and progression of sepsis, but the mechanisms that lead to cellular dysfunction, organ failure and death remain poorly defined. Peripheral blood monocytes are a major source of the effec...

Immunology

  • 2018 - 2021
  • 11 989 tis. Kč
  • 11 629 tis. Kč
  • MZ
Project

The influence of ascorbic acid on phenotyp in Charcot Marie Tooth disease type 1A (NR9517)

To evaluate an influence of ascorbic acid on phenotype of CMT1A neuropathy. The cohort of sixty patients will be treated ( AA vs placebo) fot two years. The primary efficacy outcome will be an improvement on CMTNS, electro- physiological parameters, ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2007 - 2010
  • 4 183 tis. Kč
  • 3 986 tis. Kč
  • MZ
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