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1 082 (0,078s) •

Project

Exploring the impact of somatic expansion rates on quantitative progression marker candidates (Voice) in early stages of Repeat Expansion Disorders (9F25002)

repeat expansion mutations at early disease stages/prodromal (within 5 years to predicted onset) by determining the length of the uninterrupted triplet repeat stretch, and somatic expansion index and somatic e...

Clinical neurology

  • 2025 - 2028
    • •
  • 6 206 tis. Kč
    • •
  • 6 206 tis. Kč
    • •
  • MŠMT
Project

Conformational polymorphism of DNA molecules containing trinucleotide repeats associated with genetic diseases (GA204/01/0561)

Conformational polymorphism is a probable reason of microsatellite expansions in genomes. The expansions lead to serious genetic diseases in some cases. On the basis of our previous experience with model DNA molecules, we suggest to...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 566 tis. Kč
    • •
  • 2 516 tis. Kč
    • •
  • GA ČR
Project

Conformational polymorphism and expansion fo the (CNG)n and related microsatellite DNA sequences (GA204/98/1027)

Conformational polymorphism is a likely cause of microsatellite expansions in genomes. In some cases the expansions result in serious, mainly neurodegenerative oligonucleotides containing trinucleotide and related, mostly tetranucle...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 2 404 tis. Kč
    • •
  • 1 775 tis. Kč
    • •
  • GA ČR
Project

Development of a method for prediction of pathological expansions of trinucleotide repeats in the human genome (NM7634)

that the common PCR in vitro simulates the pathological microsatellite expansions in the human propensity to the expansion to the nucleotide sequence. Carry out a bioinformatic and lenght correlates with the expansion duri...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 4 688 tis. Kč
    • •
  • 2 063 tis. Kč
    • •
  • MZ
Project

Optimization of corneal endothelial failure diagnostics in clinical practice and transplantology (NW25-07-00303)

human repeat expansion disease. The aim of the project is to verify the benefit of genotyping TCF4 repeats in patients with endothelial failure, in corneal donors between the number of trinucleotide repeats in the...

Human genetics

  • 2025 - 2028
    • •
  • 11 389 tis. Kč
    • •
  • 11 389 tis. Kč
    • •
  • MZ
Project

Creation of Algorithm for Surgical Treatment of Giant Congenital Pigment Naevi (NR8833)

The aim of the project is the complex evaluation of the condition of scars after repeated surgical procedures in giant pigment naevi with help of a special after repeated reconstructions of the defects of pigmented naevi where tissu...

FP - Ostatní lékařské obory

  • 2006 - 2008
    • •
  • 496 tis. Kč
    • •
  • 478 tis. Kč
    • •
  • MZ
Project

FXTAS (Fragile X premutation tremor/ataxia syndrome) - the extension of molecular methods in hereditary ataxias with onwards longitudinal study of patients families in the Czech Republic (NR8124)

The extension of molecular methods in hereditary ataxias with aim map of genetic situation of patients and their families. The research of Fragile X premutation tremor/ataxia syndrome (FXTAS) in the group of suspected hereditary ataxias patients and ...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 1 928 tis. Kč
    • •
  • 1 920 tis. Kč
    • •
  • MZ
Project

Y chromosome dynamics in dioecious plants intra- and interspecies genomic analysis of Silene latifolia and S. dioica (GA18-06147S)

) chromosomes. There are few studies showing how different types of repeats contribute variability and Y chromosome expansion. Our data will be confirmed by direct Y chromosome sequencing and FISH analysis. The intra- and interspeci...

Plant sciences, botany

  • 2018 - 2020
    • •
  • 9 565 tis. Kč
    • •
  • 8 578 tis. Kč
    • •
  • GA ČR
Project

Large Scale Image and Object Search as a Teacher (GAP103/12/2310)

retrieval will be pursued. This includes novel methods for automatic query expansion and complex repeated pattern analysis....

JD - Využití počítačů, robotika a její aplikace

  • 2012 - 2014
    • •
  • 3 333 tis. Kč
    • •
  • 3 333 tis. Kč
    • •
  • GA ČR
Project

Occurence of WD repeat proteins in prokaryotic cells and their possible role in a new type of regulation of gene expression in prokaryotes (GA204/96/1262)

The WD-repeat proteins carrying 4-8 repeats of conserved amino acid motif have-repeats play a role in protein-protein interaction. Up to now, WD- repeat proteins. Itis the first WD-repeat protein in which ...

EE - Mikrobiologie, virologie

  • 1996 - 1998
    • •
  • 2 038 tis. Kč
    • •
  • 1 624 tis. Kč
    • •
  • GA ČR
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