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945 (0,185s) •

Project

Intracellular and extracellular targets for antitumor activity and toxicity of ruthenium complexex (1P05OC070)

complexex of rhutenium as a new class of promising cytostatics effective in tumor cell resistant to platinum cytostatics...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2006
    • •
  • 705 tis. Kč
    • •
  • 522 tis. Kč
    • •
  • MŠMT
Project

Structure - pharmacological activity relationship of platinum and ruthenium complexes (GA307/96/0996)

The goal of these studies is to develop a systematic approach to the synthesis of metal complexex with unigue DNA binding activities capable of overcoming the problem of theselesions in cells. 2.Study the interaction of the ruthenium

CE - Biochemie

  • 1996 - 1998
    • •
  • 3 160 tis. Kč
    • •
  • 2 352 tis. Kč
    • •
  • GA ČR
Project

Characterisation of metalloproteins, key molekules for biological processes (1P05OC071)

procural of new information on role of some metalloproteins in mechanism of atitumor effect of platinium complexex...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2006
    • •
  • 805 tis. Kč
    • •
  • 522 tis. Kč
    • •
  • MŠMT
Project

Nanocrystalline oxidic semiconductors for optoelectronic applications (1P05OC069)

structural, electrochemical and photoelectrochemical research of n-semiconductor electrode modified by chemisorption of transient metall complexex......

CF - Fyzikální chemie a teoretická chemie

  • 2005 - 2008
    • •
  • 1 443 tis. Kč
    • •
  • 1 443 tis. Kč
    • •
  • MŠMT
Project

Study of the preparation and of the properties of ruthenium hydrogenation catalysts, perspectivities of their utilization in synthesis of fine chemicals (GA104/97/0890)

The proposed project is focused on the study of preparation of ruthenium recent results and literature sources show that application of ruthenium catalysts of organic compounds. Metal ions modified ruthenium catalysts, ...

CI - Průmyslová chemie a chemické inženýrství

  • 1997 - 1999
    • •
  • 1 519 tis. Kč
    • •
  • 1 095 tis. Kč
    • •
  • GA ČR
Project

The development of ruthenium antitumor compounds (OC D8.50)

was tested using model tumors, the ruthenium complexes yielded promising results. It has been shown that several ruthenium complexes are active in some model colorectal tumors resistant to cisplatin and its analogues and also that ...

FR - Farmakologie a lékárnická chemie

  • 1998 - 2001
    • •
  • 6 030 tis. Kč
    • •
  • 1 180 tis. Kč
    • •
  • MŠMT
Project

Biophysical analysis of DNA interactions with antitumor ruthenium complexes (GA204/97/P028)

ruthenium complexes. Ruthenium complexes with dimethylsulfoxide ligands and complexes. The biological properties of the ruthenium complexes chosen for our studies are interesting of the platinum group including rutheni...

CE - Biochemie

  • 1997 - 1999
    • •
  • 659 tis. Kč
    • •
  • 479 tis. Kč
    • •
  • GA ČR
Project

Synthesis and characterisation of polyolefinic macromonomers (OC 132)

synthesis of macromonomers via controlled coordoinate polymeration of olefines and transformation of live active centers into suitable tail functional groups.......

CD - Makromolekulární chemie

  • 2006 - 2006
    • •
  • 200 tis. Kč
    • •
  • 200 tis. Kč
    • •
  • MŠMT
Project

Structure and properties of paramagnetic ruthenium complexes for designing new anticancer drugs (GA15-09381S)

We propose to study novel candidates for ruthenium anticancer drugs based on ruthenium complexes protected by cucurbit[n]uril and bambus[n]uril cavitands. The ruthenium compounds will be synthesized and combined with cavita...

CF - Fyzikální chemie a teoretická chemie

  • 2015 - 2017
    • •
  • 5 685 tis. Kč
    • •
  • 5 685 tis. Kč
    • •
  • GA ČR
Project

Recognition of DNA modified by antitumor platinum and ruthenium complexes by zinc-finger proteins and topoisomerases (KJB400040601)

This application proposes to examine efficiency of various conventional and novel antitumor platinum and ruthenium coordination complexes to eject zinc from effectiveness of theplatinum and ruthenium compounds from the viewpoint eff...

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 764 tis. Kč
    • •
  • 1 764 tis. Kč
    • •
  • AV ČR
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