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8 811 (0,17s)

Project

Investigation of Complex Thick Targets Neutronics for Accelerator Driven Nuclear Power Production (8JCH1045)

a) Determine neutron spatial and energy distribution for all proposed targets; simulate neutron transport and fluences to various neutron detectors; determine energy deposition as input for simulation to be performed under c) b) Prepare comp...

Nuclear related engineering; (nuclear physics to be 1.3);

  • 2019 - 2021
  • 150 tis. Kč
  • 150 tis. Kč
  • MŠMT
Project

Evolution of metabolic pathways in complex plastid of the diatom Thalassiosira pseudonana (IAA500220502)

Diatoms possess mutlimembraned complex plastid. Such plastids have evolved are nuclear-encoded and posttranslationally imported into the complex platid using bipartite targeting presequence. Preliminary analyses of the diat...

EB - Genetika a molekulární biologie

  • 2005 - 2007
  • 1 264 tis. Kč
  • 1 264 tis. Kč
  • AV ČR
Project

Analysis of possibilities of target simulation and training battle tasks for preparation of artillery observers (MO03011100003)

Study and interactive electronic system - simulator of targets and training battle tasks that enables preparation of artillery observers and commanders and it is possibly to integrate it in complex artillery simulator.......

KA - Vojenství

  • 2000 - 2001
  • 3 800 tis. Kč
  • 3 800 tis. Kč
  • MO
Project

*Targeted supercancerostatics of new generation for leucemia therapy. (FT-TA2/081)

*Technology of specific ligands production development targeted for complexation of radionuclides. Ligands will be content reactive functional groups for conjugation with monoclonal antibody antiCD66. The conjugate will be applied i...

CC - Organická chemie

  • 2005 - 2008
  • 70 398 tis. Kč
  • 48 451 tis. Kč
  • MPO
Project

Interactions betwen viral and host cell proteins from purification of macromolecular complexes to high-resolution structures (GESCO/06/E001)

mutants by identification new targets for drug design. Here we propose toanalyze the monkey virus protein and nucleoprotein complexes that play the key in targeting to characterize specific protein complexes that ...

CE - Biochemie

  • 2006 - 2009
  • 4 500 tis. Kč
  • 4 500 tis. Kč
  • GA ČR
Project

Functional genomics of the nuclear hormone receptor transcription complex in human tumors (NC7554)

Functional genomics targeted on components of transcription complex of RNA Polymerase II order to improve diagnostics and therapy of tumors.......

FC - Pneumologie

  • 2003 - 2005
  • 4 353 tis. Kč
  • 4 325 tis. Kč
  • MZ
Project

Intracellular and extracellular targets for antitumor of ruthenium complexes (OC D20.003)

a number of complexes of ruthenium and of other group VIII transition metals in order and the biological relevance for the interaction of ruthenium complexes with the components for ruthenium complexes, responsible for the...

CE - Biochemie

  • 2002 - 2005
  • 3 265 tis. Kč
  • 1 326 tis. Kč
  • MŠMT
Project

Biomaterials based on octahedral molybdenum clusters as singlet oxygen radiosensitizers (GA18-05076S)

groups. The complexes will be used as molecular radiosensitizers with cell targeting complexes, with a focus on their applicability for radiotherapy of cancer. The complexes dark toxicity, stabilize photophysical ...

Inorganic and nuclear chemistry

  • 2018 - 2020
  • 9 622 tis. Kč
  • 8 847 tis. Kč
  • GA ČR
Project

Changes in activity of cyclin dependent kinase complexes and phosphorylation of their target proteins in functional relation to alga cell cycle events (GA204/02/1438)

The aim of the project is to follow the changes in phosphorylation of target substrates by complexes of cyclin-dependent kinases (CDKs) with cyclins including the spatial changes of complexes CDK/cyclin and their substrates...

EA - Morfologické obory a cytologie

  • 2002 - 2004
  • 5 106 tis. Kč
  • 2 646 tis. Kč
  • GA ČR
Project

Development of new, targeting polynuclear platinum and ruthenium complexes for anticancer chemotherapy. Mechanism of action (GC20-14082J)

new, targeting polynuclear platinum and ruthenium-based agents that circumvent and cellular targeting; (ii) to enhance our knowledge of the molecular and cellular level complexes of platinum group metals. The secondary obj...

Medicinal chemistry

  • 2020 - 2022
  • 6 513 tis. Kč
  • 6 432 tis. Kč
  • GA ČR
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