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7 (0,099s) •

Project

Dependence of sustained virological response on the early viral kinetics in the treatment of chronic hepatitis C patients with combination of alpha-interferon, or pegylated interferon, and ribavirin. (NI7484)

We shall make a detection of serum HCV RNA levels in chronic hepatitis C patients treated by combination of alpha-interferon, or pegylated interferon, and ribavirin by polymerase chain reaction. We shall do this evaluation before treatment, ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
    • •
  • 1 287 tis. Kč
    • •
  • 1 245 tis. Kč
    • •
  • MZ
Project

Kinetically guided removal of plazma pegylated liposomal doxorubicin to enhance the benefit of cytostatic therapy of patients with ovarian cancer. (NT14035)

. For the therapy with rheohemapheresis we suggest to use pegylated liposomal doxorubicine...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 4 967 tis. Kč
    • •
  • 4 967 tis. Kč
    • •
  • MZ
Project

Novel antifungally active conjugates of poly(ethylene glycol)s (GA203/06/0583)

Using polymers as carriers (drug delivery systems) is a progressive trend of up-to-date medicinal chemistry. A binding of the drug to a hydrophilic polymer can solve serious shortages that significantly limit therapeutic use of many biologically acti...

CC - Organická chemie

  • 2006 - 2008
    • •
  • 2 472 tis. Kč
    • •
  • 2 472 tis. Kč
    • •
  • GA ČR
Project

Solvent relaxtion in phospholipid bilayers physical understanding and biophysical applications (IAA400400503)

After the uderstanding of solvent relaxation (SR) in isotropic solvents, scinetists started abour 10 years ago to characterise SR in biosasemblies. It was our group that established the SR method for probing micro-mobilities and -polarities in biomem...

CF - Fyzikální chemie a teoretická chemie

  • 2005 - 2007
    • •
  • 1 521 tis. Kč
    • •
  • 1 521 tis. Kč
    • •
  • AV ČR
Project

Development of CXCR4 targeting -nanosystem-imaging probes for molecular imaging of cancer cells and tumor microenvironment. (TH70020002)

Project aims to develop a CXCR4 targeting- PET tracer/ Nanosystem (CXCR4-PET-NAN) to detect neoplastic and Tumor microenvironment (TME) cells in solid tumors. The added value of nanotechnology plus innovative the biological features of new developed ...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 8 490 tis. Kč
    • •
  • 4 476 tis. Kč
    • •
  • TA ČR
Project

Liposoms (drug delivery systems) in kinetically guided therapy of ovarian platinum-resistent carcinoma with doxorubicin using plasmafiltration. (NV16-30366A)

An anti-cancer drug, doxorubicin, encapsulated in small-sized pegylated liposomes (PLD) is indicated for second-line treatment of ovarian cancer and AIDS-related Kaposi´s sarcome. PLD shows a lower uptake by RES, and consequently, increased ...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 10 390 tis. Kč
    • •
  • 9 910 tis. Kč
    • •
  • MZ
Project

Sensing of hepatitis B virus-infected hepatocytes by plasmacytoid dendritic cells (GA17-15422S)

clearance effect of pegylated IFN-alpha in CHB treatment and its undesirable adverse...

EE - Mikrobiologie, virologie

  • 2017 - 2021
    • •
  • 7 608 tis. Kč
    • •
  • 6 891 tis. Kč
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  • GA ČR
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