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2 007 (0,194s) •

Project

Biophysical analysis of DNA condensation. Effect of new organometallic compounds of biological significance. (GA13-08273S)

DNA condensation in vitro serves as a model system for many processes of biological significance make it possible to predict that they can also condense DNA “downstream” processes that result from interactions of <...

BO - Biofyzika

  • 2013 - 2016
    • •
  • 5 414 tis. Kč
    • •
  • 5 414 tis. Kč
    • •
  • GA ČR
Project

DNA Condensation Monte-Carlo Simulations, Light Scattering, Fluorescence Correlation Spectroscopy in vitro and in vivo. (IAA400400621)

The DNA condensation is crucial for transport of DNA inside living cells, i.e sensitive tool for visualizing the DNA shape changes. However, the obtained data into the process itself and to explore new condense...

CF - Fyzikální chemie a teoretická chemie

  • 2006 - 2010
    • •
  • 6 738 tis. Kč
    • •
  • 6 738 tis. Kč
    • •
  • AV ČR
Project

Metallo-supramolecular helicates as DNA condensing agents and carriers for DNA delivery (GA20-00735S)

as the mechanistic details of DNA condensation. Finally, we will explore the efficiency helicates to act as carriers for DNA delivery. The dinuclear metallo helicates due, unique DNA binding properties and, as we ...

Biophysics

  • 2020 - 2022
    • •
  • 4 590 tis. Kč
    • •
  • 4 590 tis. Kč
    • •
  • GA ČR
Project

Large scale organization of chromatin (GA304/01/0729)

The cell nucleus represents the place where genomic DNA is accommodated. As the linear DNA length of a mammalian genome may be several meters and the diameter of the nucleus is only 10-15 um several levels of chromatin condensat...

EA - Morfologické obory a cytologie

  • 2001 - 2003
    • •
  • 5 749 tis. Kč
    • •
  • 4 671 tis. Kč
    • •
  • GA ČR
Project

Structure and interactions of nucleic acids and polypeptides at metal surfaces (IAA4004002)

-D) condensation. The course of 2-D condensation of nucleic acid bases...

CG - Elektrochemie

  • 2000 - 2002
    • •
  • 3 191 tis. Kč
    • •
  • 1 065 tis. Kč
    • •
  • AV ČR
Project

Adsorption of bases, nucleosides, nucleotides and polynucleotides. (IAA4004702)

in their two-dimensional (2-D) condensation and formation of a compact layer. The effect of solvent on the kinetic of 2-D condensation of nucleic acid bases and compounds used to facilitate anchoring of DNA in the scanning...

CF - Fyzikální chemie a teoretická chemie

  • 1997 - 1999
    • •
  • 2 532 tis. Kč
    • •
  • 705 tis. Kč
    • •
  • AV ČR
Project

Interstrand crosslinks induced in the genetic material by ultraviolet light (GA206/98/0626)

and studies of DNA associations in vivo. We propose to study role of the DNA primary structure, itsconformation and condensation in the formation of UV-induced interstrand. Results of these studies on model oligonucleotide...

EH - Ekologie – společenstva

  • 1998 - 2000
    • •
  • 2 440 tis. Kč
    • •
  • 1 908 tis. Kč
    • •
  • GA ČR
Project

Multimarker screening of exhaled breath condensate - a way to phenotypization of disease conected to bronchi obstriction (LH14073)

condensate. Developed methods will be used in clinical practice as part of diagnosing...

CB - Analytická chemie, separace

  • 2014 - 2016
    • •
  • 1 778 tis. Kč
    • •
  • 1 778 tis. Kč
    • •
  • MŠMT
Project

Application of biophysical methods in biotechnological and clinical praxis (IBS5004107)

to the development of a biosensor for detection of DNA damage and detection of the binding of ligand to DNA, on the other hand to the development of new cytostatics based on cis......

BO - Biofyzika

  • 2001 - 2005
    • •
  • 11 755 tis. Kč
    • •
  • 8 605 tis. Kč
    • •
  • AV ČR
Project

Utilization of physical methods of investigation of nucleic acid and protein adsorption at interfaces in medical diagnosis and biocompatibility study (GA202/08/1688)

The aim of the proposed project is to develop an electrochemical and optical method for a sensitive and cheap determination of nucleotide sequence in oligonucleotides and application of this method in medical diagnosis. The other aim of the project w...

BO - Biofyzika

  • 2008 - 2010
    • •
  • 2 052 tis. Kč
    • •
  • 2 052 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 2 007