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7 (0,08s) •

Project

New therapeutic targets in overcoming radioresistance Systematic identification of genes driving response to radiation through the integration of functional genomics and transcriptomic profiling (NW24-03-00221)

Glioblastoma, IDH-wildtype (GBM) is the most common and highly aggressive primary brain tumor. Due to its inherent heterogeneity, invasive nature, and localization, complete surgical resection is virtually impossible. Despite improv...

Oncology

  • 2024 - 2027
    • •
  • 14 956 tis. Kč
    • •
  • 14 956 tis. Kč
    • •
  • MZ
Project

Unraveling Molecular Mechanisms of Glioblastoma Treatment Resistance and Recurrence Insights from a 3D GLICO Model (NW24-08-00157)

Glioblastoma IDH-wildtype WHO G4 (GB) is a primary malignant brain tumor characterized by its resistance to therapy and poor prognosis. Despite advances in surgical techniques, targeted radiotherapy, and chemotherapeutics, GB remain...

Cell biology

  • 2024 - 2027
    • •
  • 13 773 tis. Kč
    • •
  • 13 773 tis. Kč
    • •
  • MZ
Project

Targeting vulnerabilities in amino acid metabolism in acute leukemias (NW24J-03-00069)

Although the prognosis of acute leukemia patients has improved, the overall survival is still quite low, especially in acute myeloid leukemia (AML) patients. Therefore, improvement of the therapy is necessary. One of the attractive but still unexplor...

Biochemistry and molecular biology

  • 2024 - 2027
    • •
  • 6 889 tis. Kč
    • •
  • 6 889 tis. Kč
    • •
  • MZ
Project

Allosteric modulation of nicotinic receptors (IAA100110501)

We will study the influence of allosteric modulators on nicotinic acetylcholine receptor function. We will concentrate on analysis of physostigmine allosteric action on embryonic and adult mouse muscle nicotinic receptors. Wildtype receptors...

BO - Biofyzika

  • 2005 - 2008
    • •
  • 1 792 tis. Kč
    • •
  • 1 792 tis. Kč
    • •
  • AV ČR
Project

Cooperativity of nicotinic receptors (GA202/09/0806)

of changes in activation, desensitization, inhibition and modulation of wildtype...

BO - Biofyzika

  • 2009 - 2012
    • •
  • 4 214 tis. Kč
    • •
  • 4 214 tis. Kč
    • •
  • GA ČR
Project

The role of cytochrome c oxidase subunit 4 isoforms in regulation of mitochondrial energy provision and oxidative stress (GA16-13671S)

technology, and subsequent knock-in of COX4-1 and COX4-2 wildtype and mutated variants...

CE - Biochemie

  • 2016 - 2020
    • •
  • 6 041 tis. Kč
    • •
  • 5 735 tis. Kč
    • •
  • GA ČR
Project

Machine Learning-based Suite for Advanced Diffusion MRI Analysis of Brain Gliomas (NW25J-08-00023)

, to predict molecular tumor status (e.g. IDH status), grade gliomas accurately...

Radiology, nuclear medicine and medical imaging

  • 2025 - 2028
    • •
  • 6 949 tis. Kč
    • •
  • 6 949 tis. Kč
    • •
  • MZ
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