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904 (0,082s) •

Project

Study of molecular mechanisms involved in suppression of transcription-associated genomic instability (GA17-02080S)

of collisions between transcription and replication complexes. To advance understanding of yet ill-defined molecular mechanisms underlying transcription/replication transcription/replication inte...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 9 174 tis. Kč
    • •
  • 7 836 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms involved in reactivation of replication forks stalled by co-transcriptional R-loops (GA22-08294S)

Transcription-replication conflicts (TRCs) associated with the formation of co-transcriptional RNA:DNA hybrids, termed R-loops, are a major intrinsic source of DNA replication stress and genomic instability, hallma...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 986 tis. Kč
    • •
  • 9 986 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms preventing genome damage induced by replication-transcription conflicts (LTAUSA19096)

The aim of this project is to prepare model systems for study of oncogene-induced replication-transcription conflicts and associated R-loops, characterize these events structurally as well as identify the proteins operating in preve...

Cell biology

  • 2020 - 2022
    • •
  • 4 959 tis. Kč
    • •
  • 4 959 tis. Kč
    • •
  • MŠMT
Project

Exploring mechanisms of DNA replication restart upon collisions between transcription and replication complexes (GA19-07674S)

Transcription-replication collisions (TRCs) represent a significant source of genomic instability in cells experiencing DNA replication stress. Although, understanding of how a replication fork restarts DNA synthes...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 10 396 tis. Kč
    • •
  • 9 563 tis. Kč
    • •
  • GA ČR
Project

Identification of protein complexes associated with genotoxic RNA DNA hybrids and their role in maintenance of genomic stability (LH14037)

The aim of this project is to prepare tools for the isolation of proteins associated with R-loops, identify proteins associated with these structures under different conditions promoting transcription/replication collision and R-loo...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 1 823 tis. Kč
    • •
  • 1 823 tis. Kč
    • •
  • MŠMT
Project

Molecular mechanisms involved in removing R-loops at sites of interference between DNA transcription and replication (GA25-15542S)

Transcription-replication conflicts caused by co-transcriptional RNA:DNA of tumorigenesis. We discovered that replication forks blocked by R-loops can be reactivated), and the transcription elongation fact...

Biochemistry and molecular biology

  • 2025 - 2027
    • •
  • 11 342 tis. Kč
    • •
  • 11 342 tis. Kč
    • •
  • GA ČR
Project

Relationship between replication of ribosomal genes and their transcription (GAP302/12/1885)

and participate in the formation of nucleoli. Apparently, rDNA transcription and replication, and molecular biology to reveal the reciprocal inhibitory/stimulating effects of replication and transcription machiner...

EA - Morfologické obory a cytologie

  • 2012 - 2015
    • •
  • 12 024 tis. Kč
    • •
  • 12 024 tis. Kč
    • •
  • GA ČR
Project

Spatial organisation of key nuclear domains and their protein components (LTC18048)

a) To determine the distribution of replication and transcription in the nucleolar subdomains b) To analyse distribution of histone variants in the nucleolar DNA fraction c) To create an interaction network of histone chaperones a...

Plant sciences, botany

  • 2018 - 2021
    • •
  • 3 430 tis. Kč
    • •
  • 3 430 tis. Kč
    • •
  • MŠMT
Project

Deciphering the relationship between homologous recombination and gene silencing (GA23-05284S)

The simultaneous activity of transcription and replication or DNA repair integrating transcriptional, chromatin, and molecular analyses to show that gene silencing is an inherent mechanism of the recombination-dependent

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 7 260 tis. Kč
    • •
  • 7 260 tis. Kč
    • •
  • GA ČR
Project

Simultaneous gene transcription and translation (GJ20-16013Y)

directly coupling transcription to translation. This contrasts with eukaryotic transcription and translation which are physically separated by the nuclear envelope. Nevertheless, some double-strand DNA viruses replicate in...

Biochemical research methods

  • 2020 - 2022
    • •
  • 9 834 tis. Kč
    • •
  • 9 834 tis. Kč
    • •
  • GA ČR
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