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1 043 (0,103s) •

Project

Maturation of mitochondrial energy metabolism in perinatal period (NE6555)

of the project is to study proces of maturation of PDH and respiratory chain complexes and respiratory chain complexes in muscle mitochondria due to low amount of mitochondrial......

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 5 560 tis. Kč
    • •
  • 3 639 tis. Kč
    • •
  • MZ
Project

*Development of modern biotechnological products for rapid and effective diagnosis of serious and atypical respiratory infections. (FT-TA3/098)

serious atypical respiratory diseases in human. These diagnostic kits shall utilize" polymerase chain reaction (PCR) method....

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2006 - 2009
    • •
  • 27 301 tis. Kč
    • •
  • 9 075 tis. Kč
    • •
  • MPO
Project

Biochemical and molecular basis of mitochondrial energetic metabolism in neonates (NR9410)

of respiratory chain complexes and their degradation. We will quantify mtDNA content in placental blood fromneonates (various gestational age) and analyse respiratory chain......

FG - Pediatrie

  • 2007 - 2009
    • •
  • 7 846 tis. Kč
    • •
  • 7 846 tis. Kč
    • •
  • MZ
Project

The significance of mitochondriál DNA mutations in the pathogenesis of refractory anaemia with ring sideroblasts (NC6001)

Pathogenetical part:1.isolation of mitochondrial fraction from erythroid cwlls in bone marrow,2.detection of mtDNA mutations vy RFLP,3.determinantion of activity and quantity of enzymes of respiratory chain. Clinical part:1.correlat...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 2 015 tis. Kč
    • •
  • 2 015 tis. Kč
    • •
  • MZ
Project

Oxidative metabolism in lymphocytes of obese humans (OC 918.40)

metabolism is dependent on the amount and activities of respiratory chain complexes, ATP of respiratory chain complexes, citrate synthase and pyruvate dehydrogenase.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2003
    • •
  • 2 901 tis. Kč
    • •
  • 1 010 tis. Kč
    • •
  • MŠMT
Project

The response of organism to the administration of coenzyme Q and its synthetic derivatives (GA303/09/0570)

, i.e. interactions with respiratory chain complexes, mitochondrialCoenzyme Q (CoQ) is a lipophilic benzoquinone synthesized in all plant and animal cells. Beside its role as electron carrier in the mitochondrial respiratory

CE - Biochemie

  • 2009 - 2011
    • •
  • 2 625 tis. Kč
    • •
  • 2 625 tis. Kč
    • •
  • GA ČR
Project

The role of cytochrome c oxidase subunit 4 isoforms in regulation of mitochondrial energy provision and oxidative stress (GA16-13671S)

respiratory chain function according to oxygen availability thanks to a oxygen-controlled...

CE - Biochemie

  • 2016 - 2020
    • •
  • 6 041 tis. Kč
    • •
  • 5 735 tis. Kč
    • •
  • GA ČR
Project

The role of mammalian mitochondrial glycerophosphate dehydrogenase in production of reactive oxygen species (GA303/03/0799)

Mitochondrial glycerophosphate dehydrogenase (mGPDH) is an integral part of the respiratory chain. Together with cytosolic glycerophosphate dehydrogenase, mGPDH forms chain. Expression of mGPDH is highly tissue specific and...

CE - Biochemie

  • 2003 - 2005
    • •
  • 2 161 tis. Kč
    • •
  • 2 161 tis. Kč
    • •
  • GA ČR
Project

MECHANISMUS OF Bcl-2 ACTION (NC5463)

Bcl-2 protooncogene prevents apoptosis of HeLa G cells,but induces apoptosis of BSC-40 cells.We will study its interactions with other cellular proteins and the effect on the energy metabolism,especially on mitochondrial function and glycalysis. Usin...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 2 184 tis. Kč
    • •
  • 2 184 tis. Kč
    • •
  • MZ
Project

Effect of branched-chain amino acids and saturated fatty acids on development of insulin resistance (NT14416)

acids (SFA) and branched-chain amino acids (BCAA) are potential dietary inductors biogenesis and respiratory capacity of mitochondria, lipid deposition and expression......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2013 - 2015
    • •
  • 5 659 tis. Kč
    • •
  • 5 659 tis. Kč
    • •
  • MZ
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