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5 787 (0,119s) •

Project

Regulation of PKC beta 2 in malignant and differentiating colorectal adenocarcinoma cells (GP301/02/D159)

carcinoma cells that possess the ability to differentiate accordingto expression epithelial cells of the large intestine. HT29 cells differentiate after sodium butyrate treatment, whereas Caco-2 cells...

EB - Genetika a molekulární biologie

  • 2002 - 2005
    • •
  • 745 tis. Kč
    • •
  • 745 tis. Kč
    • •
  • GA ČR
Project

Role of the cell cycle regulators, inhibitors of cyclin- dependent kinases and p300, in the differentiation of tumor cells. (IZ3955)

The role of cell cycle regulators in the differentiation of tumor cells will be studied by methods of molecular and celluar biology. E1 a oncogene will be used and the links between the differentiation and expressi...

FD - Onkologie a hematologie

  • 1997 - 1999
    • •
  • 3 119 tis. Kč
    • •
  • 2 604 tis. Kč
    • •
  • MZ
Project

Gp130 receptor-mediated differentiation of ES cells (GA301/08/0717)

of the IL-6 cytokine family and their role in the regulation of ES cell differentiation will be studied. This pathway is known to support mouse ES cells in the undifferentiated stage. However, this pathway also regulates p...

FP - Ostatní lékařské obory

  • 2008 - 2010
    • •
  • 2 712 tis. Kč
    • •
  • 2 712 tis. Kč
    • •
  • GA ČR
Project

In vitro and in vivo differentiation of umbilical cord blood stem cells into insulin producing cells (NR9060)

and differentiation of umbilical cord blood stem cells toward the phenotype of pancreatic beta-cells. The cell quality will be tested by detection of characteristic transcription as well as in-vivo by transplantat...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2009
    • •
  • 4 922 tis. Kč
    • •
  • 4 666 tis. Kč
    • •
  • MZ
Project

The role of epithelial interactions in final differentiation of mononuclear phagocytes and stem cells (ME 906)

The aim of this study is to explore a role of cell-cell contact with epithelium in differentiation of mononuclear phagocytes and hematopoietic stem cells. Peripheral blood, growth and differentiation of st...

EC - Imunologie

  • 2007 - 2011
    • •
  • 1 728 tis. Kč
    • •
  • 1 728 tis. Kč
    • •
  • MŠMT
Project

Molecular mechanisms of regulation and function of autophagy in adaptation and longevity of U cell subpopulation of differentiated yeast colonies (LD15129)

The aim of the project is to bring new knowledge regarding function and regulation of autophagy in cells of differentiated yeast colonies, namely i) new findings a role in the regulation of autophagy in differentiated colon...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 1 593 tis. Kč
    • •
  • 1 593 tis. Kč
    • •
  • MŠMT
Project

Transcriptional pulsing and the stem cell phenotype (GAP305/12/1246)

, that it creates windows of opportunity for cells to enter differentiation pathways. We propose and the imaging of differentiating ES cells using state-of-the-art fluorescence microscopy mechanisms of gene regulat...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 7 544 tis. Kč
    • •
  • 7 544 tis. Kč
    • •
  • GA ČR
Project

Developmental potential and molecular differentiation of pig follicular granulosa cells in vitro (GA523/05/2062)

, differentiated cells from large antral follicles. A new, specific method of quantitative real differentiating cells, in cells with modified estrogen/ER signaling system and in EGF that granulose cell...

ED - Fyziologie

  • 2005 - 2007
    • •
  • 1 838 tis. Kč
    • •
  • 1 838 tis. Kč
    • •
  • GA ČR
Project

The role of p27 in differentiation of embryoid bodies (KJB5039301)

their differentiation. The changes in levels and configurations of cell cell cycle regulators in differentiating cells are thought to be responsible primarily for slowing down their cycling and intensity ...

EB - Genetika a molekulární biologie

  • 2003 - 2003
    • •
  • 375 tis. Kč
    • •
  • 280 tis. Kč
    • •
  • AV ČR
Project

The role of nuclear hormone receptors in regulation of differentiation of cancer cells. (NM6253)

A study focused on identification of nuclear hormone receptors and their regulatory pathways may be important for regulation of differentiation of cancer cells.......

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 3 200 tis. Kč
    • •
  • 3 200 tis. Kč
    • •
  • MZ
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