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326 (0,066s) •

Project

Role of chromatin remodeling proteins in hematopoietic stem cells and leukemogenesis (LH15170)

The proposed results include: a) new gene-inactivated and b) transgenic models to study chromatin-remodeling gene Smarca5 (Snfa2h) in mouse. The results are primarily academic such as the new knowledge of a) what mechanisms utilize ...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 1 985 tis. Kč
    • •
  • 1 985 tis. Kč
    • •
  • MŠMT
Project

HMGB1 protein involvement in nucleosome dynamics and transcription factors binding (GA15-01354S)

/disruption of the nucleosome structure by ATP-dependent remodeling complexes. Chromatin remodeling and binding of a number of transcription factors to DNA is stimulated (in the presence or absence of RSC chromatin...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 4 844 tis. Kč
    • •
  • 4 844 tis. Kč
    • •
  • GA ČR
Project

In search of the specificity for ISWI chromatin-remodeling activities. (GA19-03586S)

Tissue development is guided by processes that initiate expression of some mRNAs while others are silenced. Genetic programs are defined by DNA binding factors that navigate chromatin remodeling complexes to regions that become tran...

Hematology

  • 2019 - 2021
    • •
  • 9 645 tis. Kč
    • •
  • 9 474 tis. Kč
    • •
  • GA ČR
Project

The effect of histone deacetylase inhibitors on TEL/AML1 - positive leukaemic cells (NR8316)

Using histone deacetylase inhibitors, we will study chromatin remodelling leading to apoptosis and differentiation of TEL/AML1-positive leukaemic cells. We will analyse in vitro effect of this therapy on the changes of cell cycle an...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 3 877 tis. Kč
    • •
  • 3 834 tis. Kč
    • •
  • MZ
Project

Role of chromatin remodelling factors interactions in nutrient-controlled gene expression in yeast (IAA5020102)

. The gene belongs to the SWI/SNF family of transcriptional activators with a chromatin remodelling activity. This proposal seeks support to continue analysis of the role......

EA - Morfologické obory a cytologie

  • 2001 - 2004
    • •
  • 5 099 tis. Kč
    • •
  • 3 876 tis. Kč
    • •
  • AV ČR
Project

Analysis of replication and DNA damage response in plants deficient in accurate chromatin assembly (GP13-11563P)

Correct chromatin assembly is in each cell regulated by chromatin remodelling complexes and histone chaperones. One of the most important chromatin remodellers is the Chromatin Assembly Factor 1 (...

EB - Genetika a molekulární biologie

  • 2013 - 2015
    • •
  • 2 603 tis. Kč
    • •
  • 2 603 tis. Kč
    • •
  • GA ČR
Project

Spatial organisation of key nuclear domains and their protein components (LTC18048)

a) To determine the distribution of replication and transcription in the nucleolar subdomains b) To analyse distribution of histone variants in the nucleolar DNA fraction c) To create an interaction network of histone chaperones and selected ch...

Plant sciences, botany

  • 2018 - 2021
    • •
  • 3 430 tis. Kč
    • •
  • 3 430 tis. Kč
    • •
  • MŠMT
Project

Regulation of hematopoietic stem cell differentiation by chromatin remodeling SWI/SNF2 ATPase Smarca5 (Snf2h) in mouse. (GAP305/12/1033)

Chromatin remodeling plays a key role in transcription, replication and gene repair by utilizing energy-dependent mechanisms such as sliding of DNA in respect and indispensable chromatin remodeling ATPase that is h...

EB - Genetika a molekulární biologie

  • 2012 - 2016
    • •
  • 14 550 tis. Kč
    • •
  • 14 550 tis. Kč
    • •
  • GA ČR
Project

Mouse conditional model of chromatin remodeling factor Snf2h inactivation to study its role in hematopoiesis and leukemogenesis (NR9021)

In this application I propose experiments to further investigate the role of Snf2h in normal hematopoiesis and in the development of acute leukemia in mice using conditional knockout model. In this application I also propose experiments to study the ...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 10 794 tis. Kč
    • •
  • 10 492 tis. Kč
    • •
  • MZ
Project

Altered function and composition of the chromatin-remodeling complex SWI/SNF in the progression of lung carcinoma and melanoma (NR9319)

The SWI/SNF chromatin-remodeling complex functions as a tumor suppressor and several of its subunits (Brm, Brg1 a INI1) were found to be mutated in human tumors. We propose to study the expression of the SWI/SNF components in non-sm...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 7 871 tis. Kč
    • •
  • 7 860 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 326