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13 (0,099s) •

Project

Preparation of monoclonal antibodies against kinesin for nanotechnology_1 (OE68/1)

Kinstruction of a panel of hybridomas producing monoclonal antibodies against kinesin. The use of these antibodies for development of diagnostic kit and for biomolecular nanoactuals.......

FP - Ostatní lékařské obory

  • 2000 - 2002
    • •
  • 7 928 tis. Kč
    • •
  • 2 388 tis. Kč
    • •
  • MŠMT
Project

Preparation of monoclonal antibodies against kinesin for nanotechnology_2 (OE68/2)

Construction of a panel of hybridomas producing monoclonal antibodies against kinesin. The use of these antibodies for development of diagnostic kit and for biomolecular nanoactuators.l......

FP - Ostatní lékařské obory

  • 2000 - 2002
    • •
  • 9 188 tis. Kč
    • •
  • 2 288 tis. Kč
    • •
  • MŠMT
Project

Recombinant antigens for diagnostic kits (OE85)

It is expected that bacterial expression and purification procedure will provide recombinant antigens of diagnostic importance in the standart and uniform qualities. The first commercially interesting antigens are: Glutathione s-transferase, thyroid ...

FP - Ostatní lékařské obory

  • 2001 - 2003
    • •
  • 8 071 tis. Kč
    • •
  • 3 771 tis. Kč
    • •
  • MŠMT
Project

Interplay between the regulations of cell cycle and ciliogenesis (GA21-21612S)

, namely kinesin KIF14 and small RHO GTPases. Recent data clearly point to a crucial...

Cell biology

  • 2021 - 2024
    • •
  • 9 006 tis. Kč
    • •
  • 9 006 tis. Kč
    • •
  • GA ČR
Project

Regulation of primary cilia by cellular kinases (LTAUSA19030)

The main goal of the project is to understand molecular principles of interaction between selected cellular kinases and the primary cilium. We will (1) define the functional consequences of ICK-mediated phosphorylation of KIF3A and KIF3B in vitro and...

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2022
    • •
  • 7 110 tis. Kč
    • •
  • 7 110 tis. Kč
    • •
  • MŠMT
Project

Molecular mechanism of mitochondrial movement between cells (GA18-10832S)

to a biologically more complex and plausible model. We will test the involvement of the kinesin...

Cell biology

  • 2018 - 2020
    • •
  • 7 691 tis. Kč
    • •
  • 7 691 tis. Kč
    • •
  • GA ČR
Project

Role of horizontal transfer of mitochondria in brain tumour formation (GA20-05942S)

and that this involves the kinesin-dependent mobility system. Our findings will contribute...

Cell biology

  • 2020 - 2022
    • •
  • 9 817 tis. Kč
    • •
  • 9 817 tis. Kč
    • •
  • GA ČR
Project

Reconstitution of mitochondrial transport system in vitro (GA18-08304S)

Mitochondrial trafficking is essential for a number of biological process, such as the maintenance of neuronal function. Components of the mitochondrial motor-adaptor complex have been recently identified, but the precise composition and the molecula...

Biophysics

  • 2018 - 2020
    • •
  • 6 258 tis. Kč
    • •
  • 6 258 tis. Kč
    • •
  • GA ČR
Project

Cilia-related Tau tubulin kinase 2 in health and disease structure and function (GA22-13277S)

Tau tubulin kinase 2 (TTBK2) has emerged as a crucial regulator of primary cilia, sensory organelles with fundamental roles in both development and disease. However, the full understanding of what this kinase does (on the molecular level) that makes ...

Cell biology

  • 2022 - 2024
    • •
  • 7 395 tis. Kč
    • •
  • 7 395 tis. Kč
    • •
  • GA ČR
Project

High-fidelity fast tracking of protein motion mechanisms (GA18-19705S)

Despite the progress in refining static structures of proteins including protein motors the understanding of their chemical and mechanical functions remain indistinct. In this project we advance the accuracy and speed in direct tracking of single pro...

Biophysics

  • 2018 - 2021
    • •
  • 7 197 tis. Kč
    • •
  • 6 435 tis. Kč
    • •
  • GA ČR
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