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151 (0,123s) •

Project

Digestive enzymes of Schistosoma_ New target for the treatment of parasitic (KJB400550516)

proteases critical for metabolism of Schistosoma. The selected proteases. The activation process will be analyzed for the protease zymogens processed to the mature for interactionwith the active site of the protease

CE - Biochemie

  • 2005 - 2007
    • •
  • 888 tis. Kč
    • •
  • 888 tis. Kč
    • •
  • AV ČR
Project

Detection and characterisation of HIV-1 mutants resistant to specific therapy with protease inhibitors evolution of the resistant species and their interactions with other viral proteins (NI6339)

Resistant HIV strains in patients treated by protease inhibitors. Sequencing, cloning and analysis of recombinant mutant proteases. Design of a broad specificity inhibitor. Co-evolution of protease and pther viral genes in ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2000 - 2002
    • •
  • 4 431 tis. Kč
    • •
  • 3 170 tis. Kč
    • •
  • MZ
Project

Molecular mechanism of function of proteases in breast cancer (1P04OCB20.002)

The project is on structure-function relationship in cathepsin D protease playing a critical role in breast cancer....

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 400 tis. Kč
    • •
  • 1 800 tis. Kč
    • •
  • MŠMT
Project

Functional proteomics of plant defense proteins (OC09007)

and their protein-protein interactions. It concentrates on protease inhibitors the enzymatic activity of digestive proteases of insect herbivores. Plant protease for the identification and functional characterization of pl...

CE - Biochemie

  • 2009 - 2011
    • •
  • 1 250 tis. Kč
    • •
  • 1 250 tis. Kč
    • •
  • MŠMT
Project

Analysis of Drug Resistance to HIV-1 Protease Inhibitors (IZ4059)

Resistant mutants of the HIV protease from the blood lymphocytes of AIDS patients treated with protease inhibitors will be amplified, sequenced, characterized in vitro and in tissue culture and tested with a panel of structurally di...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1997 - 1999
    • •
  • 2 136 tis. Kč
    • •
  • 2 136 tis. Kč
    • •
  • MZ
Project

Using the experimental and theoretical methods for structure analysis of HIV protease complexes with selected inhibitors (IAA4050811)

The aim is the determine structure of HIV protease complexes with selected of the inhibition differences observed with wild and mutated protease and to generalize of wild and mutant protease isolated from patients with deve...

CD - Makromolekulární chemie

  • 1998 - 2001
    • •
  • 7 855 tis. Kč
    • •
  • 3 428 tis. Kč
    • •
  • AV ČR
Project

Insights into the dynamics of the ATP-dependent human mitochondrial Lon protease by its three-dimensional electron microscopic structural analysis (GP13-32339P)

Lon proteases are the most flexible ATP-dependent proteases, which are both of these proteases are linked with dystrophies, neurodegenerative diseases and cancer. A deeper-ase cycle. 3D structure of any flexible Lon pro...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 2 835 tis. Kč
    • •
  • 2 835 tis. Kč
    • •
  • GA ČR
Project

Molecular characterisation of resistant mutants of viral protease from HIV-positive patients developed under the selection pressure of protease inhibitors design of novel inhibitors and diagnostics (NR8571)

The project involves analysis of resistance development in HIV-positive patients treated by protease inhibitors in the CR, design of novel, non-infectious phenotypic resistance assays and design of novel inhibitors, active against resistant ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2005 - 2007
    • •
  • 3 829 tis. Kč
    • •
  • 3 621 tis. Kč
    • •
  • MZ
Project

The role of surface proteases in host-parasite interactions (8J19AT036)

proteases of S. mansoni: SmCB2, SmPOP and SmSP2. We hypothesize that these enzymes. The project will provide new information on tegumental proteases as potential target: The three representative types of schistosomal proteases<...

Biochemistry and molecular biology

  • 2019 - 2021
    • •
  • 128 tis. Kč
    • •
  • 128 tis. Kč
    • •
  • MŠMT
Project

Membrane proteases in cell differentiation. Mechanisms of their function and their particip. in the activation of biol. active synthetic peptide precursors (GA303/96/1482)

Membrane proteases are involved in mechanism of signal transduction, cell. However, the exact role of proteases in cell cycle regulation is not known. Our. Specific inhibitors and antibodies against several membrane proteases

CE - Biochemie

  • 1996 - 1998
    • •
  • 1 710 tis. Kč
    • •
  • 1 438 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 151