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38 (0,094s) •

Project

Study of Calcium-Mediated Modulation of Glutamate Receptors and Excitatory Synaptic Transmission (GA309/93/0587)

CE - Biochemie

  • 1993 - 1995
    • •
  • 259 tis. Kč
    • •
  • 518 tis. Kč
    • •
  • GA ČR
Project

Molecular properties and regulation of glutamate receptor function (GA309/97/0517)

Glutamatergic synapses mediate most of the excitatory synaptic transmission in the vertebrate central nervous systém. In view of the role of glutamate receptors in the function of the c.n.s. under normal and pathological conditions, it is im...

FH - Neurologie, neurochirurgie, neurovědy

  • 1997 - 1999
    • •
  • 3 940 tis. Kč
    • •
  • 1 769 tis. Kč
    • •
  • GA ČR
Project

Developmental plasticity of GABA- and glycinergic systems in the rat medial nucleus of the trapezoid body (GA309/03/1158)

Medial nucleus of trapezoid (MNTB) plays an important role in sound localization detection in mammals. Principal cells in the MNTB receive both excitatory and inhibitory inputs. Excitatory nerve terminals, calyces of Held, are gluta...

ED - Fyziologie

  • 2003 - 2005
    • •
  • 2 329 tis. Kč
    • •
  • 2 329 tis. Kč
    • •
  • GA ČR
Project

What are long-term consequences of brain damage and neuroprotective therapy on psychomotor development of immature individuals? (NF6474)

examined. Toprevent consequences of status epilepticus antagonists of excitatory...

FH - Neurologie, neurochirurgie, neurovědy

  • 2001 - 2003
    • •
  • 3 757 tis. Kč
    • •
  • 1 758 tis. Kč
    • •
  • MZ
Project

The role of spinal inhibitory neurons in the development of painful states. (GA20-19136S)

of inhibitory postsynaptic currents and modulation of excitatory postsynaptic currents in identified (excitatory and inhibitory) dorsal horn neurons in models of pain (neuropathic......

Neurosciences (including psychophysiology)

  • 2020 - 2022
    • •
  • 6 209 tis. Kč
    • •
  • 6 209 tis. Kč
    • •
  • GA ČR
Project

Delineating the mechanisms that regulate specific NMDA receptor subtypes in mammalian neurones (GA20-12420S)

N-methyl-D-aspartate receptors (NMDARs) are a subclass of glutamate receptors that play an essential role in excitatory neurotransmission in the mammalian brain and are associated with the pathogenesis of many neurodegenerative conditions, i...

Pharmacology and pharmacy

  • 2020 - 2023
    • •
  • 12 389 tis. Kč
    • •
  • 12 296 tis. Kč
    • •
  • GA ČR
Project

Regulation of trafficking and function of the GluN3A-containing NMDA receptors in the mammalian neurons (GA18-04329S)

N-methyl-D-aspartate receptors (NMDARs) play critical roles in excitatory neurotransmission and excitotoxicity in mammalian neurones. Both the number and type of NMDARs present at the neurone’s cell surface are regulated at multiple levels, ...

Neurosciences (including psychophysiology)

  • 2018 - 2020
    • •
  • 6 821 tis. Kč
    • •
  • 6 593 tis. Kč
    • •
  • GA ČR
Project

Functional Consequences of Metabotropic Glutamate Receptor 1a and 1b Splice Variants Assembly in Heterodimeric Complexes (GAP303/12/2408)

Postsynaptic metabotropic glutamate receptors 1 (mGluR1) modulate excitatory neurotransmission. Dimerization is obligatory for their function. Their intracellular Carboxyl termini mediate interactions with trafficking, regulatory and scaffol...

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2016
    • •
  • 9 875 tis. Kč
    • •
  • 9 875 tis. Kč
    • •
  • GA ČR
Project

Structural determinants of transduction of the metabotropic glutamate receptors (NL6114)

Functional tests in the heterologous systems of glutamate metabotropic receptors modified using classical mutagenesis techniques will reveal the portions of the receptors involved in signal transduction determination Understanding the molecular mecha...

ED - Fyziologie

  • 2000 - 2002
    • •
  • 2 031 tis. Kč
    • •
  • 1 886 tis. Kč
    • •
  • MZ
Project

Therapy of convulsive status epilepticus - experimental and clinical study (NL5745)

Pilocarpina-induced status epilepticus in rats will be treated either clasically (clonazepam or thiopental anesthesia) or experimentally (antagonists of excitatory aminoacid receptors or calcium channel blockers). Spontaneous recurrent seizu...

FR - Farmakologie a lékárnická chemie

  • 1999 - 2001
    • •
  • 1 255 tis. Kč
    • •
  • 1 252 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 38