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88 (0,086s) •

Project

Physiologically based prediction of pharmacokinetics prior to in vivo studies Focus on hepatic and renal drug elimination (1P05OC061)

possibilities of combined usage of in vitro methods and computational models in silico for prediction of pharmacokinetics in vivo...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2008
    • •
  • 2 526 tis. Kč
    • •
  • 2 526 tis. Kč
    • •
  • MŠMT
Project

Rational design of drug delivery systems based on tailored biodegradable polymers using an iterative in silico and experimental approach (GA22-07164S)

The objective is to explore the current possibilities of in silico approaches as tools for the rational design of drug delivery systems. The project consists of interconnected research activities involving both experimental and theoretical u...

Pharmacology and pharmacy

  • 2022 - 2024
    • •
  • 8 862 tis. Kč
    • •
  • 8 352 tis. Kč
    • •
  • GA ČR
Project

In silico drug design based on advanced semiempirical quantum mechanical methods accurately describing noncovalent interactions (GAP208/11/0295)

Develop fast and accurate methods for computer-aided design of new drugs based on semi-empirical quantum chemical methods PM6-DH2 correctly describing the various types of non-covalent interactions. Besides interaction enthalpy and entropy, includes ...

CF - Fyzikální chemie a teoretická chemie

  • 2011 - 2011
    • •
  • 1 000 tis. Kč
    • •
  • 1 000 tis. Kč
    • •
  • GA ČR
Project

Development and clinical evaluation of hybrid closed loop AndroidAPS (TJ02000342)

The aim of the project is to assess the safety and efficiency of AndroidAPS software. 1) To analyze the safety and risk analysis of the AndroidAPS software in a computer in silico model (6 months) 2) To conduct a randomized prospective trial...

Endocrinology and metabolism (including diabetes, hormones)

  • 2019 - 2021
    • •
  • 8 054 tis. Kč
    • •
  • 6 553 tis. Kč
    • •
  • TA ČR
Project

Developing a novel Casein Kinase 1 inhibitor for treatment of pancreatic cancer An AI-integrated approach (7D241001)

1/ Best-in-class CK1 inhibitor lead (CI-CK1i) validated in in vitro, in vivo, and in silico models for efficacy in pancreatic cancer (PANC) in various combinations with existing treatments, including standard-of-care gemcitabine, FOLFIRINOX,...

Oncology

  • 2024 - 2027
    • •
  • 19 821 tis. Kč
    • •
  • 11 883 tis. Kč
    • •
  • MŠMT
Project

CHEESE, the superfast platform for in silico drug discovery (TQ18000015)

Start-up Deep MedChem aims to become the "Google" for medicinal chemists by being the company of first choice for searching the vast chemical spaces of molecules in computational (in-silico) drug discovery. With its unique CHEESE (Chemical E...

Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

  • 2025 - 2025
    • •
  • 1 025 tis. Kč
    • •
  • 717 tis. Kč
    • •
  • TA ČR
Project

Alternative and predictice methods and procedures in testing of irritation and sensitisation of chemicals (SP/1B5/87/07)

Implenamtation of the alternative and prediction methods into practice...

DN - Vliv životního prostředí na zdraví

  • 2007 - 2010
    • •
  • 13 758 tis. Kč
    • •
  • 8 715 tis. Kč
    • •
  • MŽP
Project

In vitro, in vivo and in silico study on overcoming bacterial resistance via combination of antibiotics with silver nanoparticles and silver compounds (GA15-22248S)

nanoparticles and silver compounds using in vitro, in vivo and in silico methods. Another...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2017
    • •
  • 8 797 tis. Kč
    • •
  • 8 797 tis. Kč
    • •
  • GA ČR
Project

In-silico Workflow for Lipid-Mediated Active Pharmaceutical Ingredients Delivery Systems (GA25-18467S)

builder, a versatile LNC builder, and a comprehensive protocol for in-silico and lead to the in-silico design of precisely tailored LNCs in the future.......

Physical chemistry

  • 2025 - 2027
    • •
  • 5 109 tis. Kč
    • •
  • 5 109 tis. Kč
    • •
  • GA ČR
Project

In vitro and in silico identification of non-canonical DNA structures in genomic DNA sequences (GA204/08/1560)

will improve (and where necessary develop) tools for in silico prediction of these DNA...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 2 647 tis. Kč
    • •
  • 2 647 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 88