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929 (0,284s) •

Project

The SMC5/6 complex in nucleome organization (LTC20033)

a) Characterization of activities of the SMC5/6 complexes b) Determination of the chromatin localization and dynamics of SMC5/6 c) Identification of chromatin loops dependent on SMC5/6 activities d) Development of visual...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 7 289 tis. Kč
    • •
  • 7 289 tis. Kč
    • •
  • MŠMT
Project

Synthesis and biological activity studies of 6-(fluoroalkyl)- and 6-(fluoroalkenyl)purine derivatives (GA203/98/P027)

The subject of this grant application is the synthesis and biological activity studies of 6-(fluoroalkyl)- and 6-(fluoroalkenyl)- derivatives of purine bases, nucleosides, nucleotides and their acyclic analogues. A key step in their...

CE - Biochemie

  • 1998 - 1999
    • •
  • 1 233 tis. Kč
    • •
  • 382 tis. Kč
    • •
  • GA ČR
Project

Role of the SMC5/6 complex and its interaction partners in DNA damage repair (GA20-05095S)

are amongst the key factors maintaining genome integrity. Particularly, the SMC5/6 complex is involved in repair of genomic DNA. However, it is still not clear how SMC5/6 participates in DNA repair. Therefore, we aim to analyse SMC...

Plant sciences, botany

  • 2020 - 2022
    • •
  • 9 153 tis. Kč
    • •
  • 9 120 tis. Kč
    • •
  • GA ČR
Project

Effect of human herpesvirus - 6 (HHV-6) on patogenesis of human diseases. (IZ1629)

9F - 9

  • 1993 - 1995
    • •
  • 315 tis. Kč
    • •
  • 630 tis. Kč
    • •
  • MZ
Project

Quantification of intra-amniotic inflammation in late preterm prelabour rupture of membranes associated with the response of amniotic fluid proteome (NU21J-07-00058)

, the determination of interleukin-6 (IL-6) in amniotic fluid is frequently used to confirm or reject the presence of IAI in PPROM. However, the conclusive IL-6 cut-off value as a response to IAI may define the threshold ex...

Obstetrics and gynaecology

  • 2021 - 2024
    • •
  • 4 748 tis. Kč
    • •
  • 4 748 tis. Kč
    • •
  • MZ
Project

The study of genotoxicity of sarin, soman and HI-6 oxime, and their influence on the effect of mutagenic and carcinogenic compounds (MO66021299108)

The risk assessment of the carcinogenicity of low doses of nerve paralytic agents and HI-6....

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 487 tis. Kč
    • •
  • 487 tis. Kč
    • •
  • MO
Project

Clinical contribution of evaluation of purine metabolism enzymes and mercaptopurine metabolites during therapy of azathioprine in patients with ulcerative colitis and Crohn´s disease (NK7276)

Prospective study evaluates clin. importance of determination of purine metabolism and determination of 6-MP metabolites with the regarding to minimalise risks of side effects and to enhance the efficacy of long term azathiorine therapy in p...

FP - Ostatní lékařské obory

  • 2002 - 2004
    • •
  • 1 728 tis. Kč
    • •
  • 1 695 tis. Kč
    • •
  • MZ
Project

Interleukin IL-6 in eye aqueous humor (IZ4096)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1997 - 1998
    • •
  • 528 tis. Kč
    • •
  • 528 tis. Kč
    • •
  • MZ
Project

Development of an air cooled engine EURO 6 (EG17_106/0012415)

Development of an air cooled engine EURO 6...

JQ - Strojní zařízení a nástroje

  • 2017 - 2021
    • •
  • 80 396 tis. Kč
    • •
  • 27 488 tis. Kč
    • •
  • MPO
Project

Synthesis of helicenes via cycloisomerization of biphenylylnaphthalene and 1,8-diarylnaphthalene derivatives (GAP207/10/1124)

of modular approach for synthesis of [6]helicenes, recently developed in our group, to chemistry of aza- and diaza[6]helicenes. Complexation properties of heterohelicenes to transition metals will be also studied. Furthermore, asym...

CC - Organická chemie

  • 2010 - 2012
    • •
  • 2 016 tis. Kč
    • •
  • 2 016 tis. Kč
    • •
  • GA ČR
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