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24 (0,09s) •

Project

CpG methylation of human endogenous retroviruses and LINEs (GA204/05/0939)

CpG methylation of DNA is a key regulator of gene expression in vertebrates, especially in mammals and birds, and most of CpG dinucleotides out of CpG islands and retroelement copies, which are generally supposed to be geno...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 3 647 tis. Kč
    • •
  • 3 647 tis. Kč
    • •
  • GA ČR
Project

Development of CpG methylation of HIV-1 promoter and its stabilizing effect on the latent provirus reservoir longitudinal study in patients (GAP304/12/1736)

of the mechanisms of latency maintenance. In our previous work we have shown that CpG clinical longitudinal study we will analyze the HIV-1 CpG methylation dynamics directly of CpG methylation of HIV-1 promoter in the late...

EE - Mikrobiologie, virologie

  • 2012 - 2016
    • •
  • 3 885 tis. Kč
    • •
  • 3 885 tis. Kč
    • •
  • GA ČR
Project

Improvement of the long-term expression and anti-methylation protection of RSV based retroviral vectors (IAA5052207)

into the heterologous mammalian cell genome. Such inactivation is probably caused by CpG methylation to CpG islands. We plan to continue our studies with insertion of minimum necessary CpG island sequence and creation of R...

EE - Mikrobiologie, virologie

  • 2002 - 2004
    • •
  • 1 743 tis. Kč
    • •
  • 1 646 tis. Kč
    • •
  • AV ČR
Project

Development and implementation of a clinical practice guideline for falls prevention of hospitalized patients (NT14502)

of available foreign CPGs. The selected CPG will be translated into Czech and by expert of the CR. Adapted CPG will be verified during one year at clinics of acute and long of recommendation and interventions of CPG

FQ - Veřejné zdravotnictví, sociální lékařství

  • 2013 - 2015
    • •
  • 1 659 tis. Kč
    • •
  • 1 659 tis. Kč
    • •
  • MZ
Project

A pilot study of the importance of the genotype - phenotype correlation in the diseases due to amplification of the triplet repetitive sequences. (IZ2080)

9F - 9

  • 1994 - 1996
    • •
  • 315 tis. Kč
    • •
  • 630 tis. Kč
    • •
  • MZ
Project

Molecular analysis of the MeCP2 gene in patients with Rett syndrome (GP301/01/P068)

This postdoctoral application is connected with projects ongoing in the "Laboratory for the study of mitochondrial defects" in Department of Pediatrics and adolescent medicine, 1st Faculty of Medicine, Charles University, Prague. Methyl CpG ...

CE - Biochemie

  • 2001 - 2003
    • •
  • 746 tis. Kč
    • •
  • 711 tis. Kč
    • •
  • GA ČR
Project

Pattern of DNA methylation in retroviral regulatory sequences (GA204/01/0632)

CpG methylation of proviral DNA is the key mechanism of transcriptional regulation of retroviruses by the host cell. We and others have obtained preliminary data that the sequence-specific pattern of methylation, i.e. the methylation status ...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 657 tis. Kč
    • •
  • 2 210 tis. Kč
    • •
  • GA ČR
Project

Determination of SNP and DNA methylation profiles in patients with myelodysplatic syndrome by microarrays. (NS9634)

Annotation 1: The aim of the project is determination of SNP and DNA methylation profiles in MDS patients. Annotation 2: We will use Illumina microarrays, "Cancer SNP Panel" for detection of 1421 SNPs located in 408 genes and "Methylation Cancer Pane...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 5 986 tis. Kč
    • •
  • 5 986 tis. Kč
    • •
  • MZ
Project

Novel DNA and RNA oligonucleotides with Phosphonothioate and Phosphonoamidate Internucleotide Linkages. (GA13-26526S)

Project is aimed at the synthesis of structurally diverse, isopolar phosphonate oligonucleotides (ONs) with the nuclease-stable, phosphonate-type internucleotide linkage as potential (i) tools for gene expression regulation (antisense ONs, siRNAs), (...

CC - Organická chemie

  • 2013 - 2016
    • •
  • 11 970 tis. Kč
    • •
  • 11 970 tis. Kč
    • •
  • GA ČR
Project

The efect of methylation and acetylation on chromatin structure (GP202/03/D033)

metaphase chromosomes according to the content of CpG islands will be visualised using...

EB - Genetika a molekulární biologie

  • 2003 - 2006
    • •
  • 736 tis. Kč
    • •
  • 736 tis. Kč
    • •
  • GA ČR
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