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6 200 (0,368s) •

Project

A Role of Interleukin 8 and other cytokines in the Pathogenesis of the Heparin- induced Thrombocytopenia (NI6063)

Heparin-induced immune-mediated thrombocytopenia (HIT-II) - possible reactivity- induced immune-mediated thrombocytopenia (HIT- II) - verification of the possibility to measure serotonin release in patients with HIT- II by ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2000 - 2002
    • •
  • 3 896 tis. Kč
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  • 3 819 tis. Kč
    • •
  • MZ
Project

Reshaping early-stage drug discovery by Artificial Intelligence (TP04020039)

Our novel award-winning AI-based software, deepHitMiner, enriches the top-scored compounds with real hits, thus fewer experiments are needed, and more candidate drugs have a chance to meet the requirements to enter the preclinical phase. Thi...

Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

  • 2022 - 2022
    • •
  • 2 145 tis. Kč
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  • 1 000 tis. Kč
    • •
  • TA ČR
Project

Development of a cybernetic assistant for small arms for the increased probability and safety of hitting a target. (TH03010191)

1) Development of an electronically regulated firing mechanism for assault rifles. 1.1) Field test of simplified electronically regulated firing mechanism with basic fire control. 2) Development of advanced rifle scope with fire control. 3) Develop...

Materials engineering

  • 2018 - 2021
    • •
  • 19 616 tis. Kč
    • •
  • 10 851 tis. Kč
    • •
  • TA ČR
Project

Typical return times in dynamical systems (KJB100750901)

Recurrence is one of the key concepts in topological dynamics, ergodic and information theories. Especially, limit distributions of return times in dynamical systems and stationary processes have been intensively studied. This field covers f...

BA - Obecná matematika

  • 2009 - 2011
    • •
  • 588 tis. Kč
    • •
  • 588 tis. Kč
    • •
  • AV ČR
Project

Exploration of the TPP riboswitch as a new target for antibiotics (8F19007)

riboswitch ligands 4. Validate the screening hits 5. Improve the affinity of at least two hit series by 10 fold 6. Obtain ligands that have antibiotic activity against key......

Microbiology

  • 2019 - 2023
    • •
  • 2 333 tis. Kč
    • •
  • 2 333 tis. Kč
    • •
  • MŠMT
Project

Discovery of promissing chemotherapeutic candidates in cyanobacteria using high-throughput screening mode of action and molecular targets. (GF21-05649K)

of the transcriptome, the cancer cell line of interest will be exposed to selected hits at half which we obtained a number of promising hits with potent anticancer activity, will be employed to reveal molecular targets of nostatin ...

Pharmacology and pharmacy

  • 2021 - 2024
    • •
  • 8 193 tis. Kč
    • •
  • 8 193 tis. Kč
    • •
  • GA ČR
Project

Development of method for membrane protein target identification of biologically active small molecules (GA23-05642S)

Phenotypic screening often yields hit molecules with an unknown modes of action. For further development of these hits, it is necessary to identify their target protein/receptor. To increase the affinity of the conjugate to its rece...

Polymer science

  • 2023 - 2025
    • •
  • 8 931 tis. Kč
    • •
  • 8 706 tis. Kč
    • •
  • GA ČR
Project

Security of International inovation centers activity. (ME 713)

Project is focused on cooperation of institutions in Czech Republic and Russian federation.Project will hit many areas(for example technology industry etc.).......

AE - Řízení, správa a administrativa

  • 2003 - 2007
    • •
  • 7 114 tis. Kč
    • •
  • 7 114 tis. Kč
    • •
  • MŠMT
Project

De novo design of synthetically feasible and biologically active compounds guided by artificial intelligence (LUAUS23262)

evaluations to save time on the computational stage and speed up the whole discovery...

Physical chemistry

  • 2023 - 2026
    • •
  • 11 818 tis. Kč
    • •
  • 11 818 tis. Kč
    • •
  • MŠMT
Project

MIHRIL II - progressive ballistic armor for defense forces (FW06010271)

the requirements for weight and cost minimization, at the same time the requirement for good hits. The maximum rate of injury to the subject by multihits will be determined......

Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)

  • 2023 - 2025
    • •
  • 16 291 tis. Kč
    • •
  • 11 378 tis. Kč
    • •
  • TA ČR
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