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610 (0,078s) •

Project

Molecular mechanisms of bacterial survival in harsh conditions (GP13-27150P)

in hosts. In stationary phase, a key regulatory molecule is 6S RNA that inhibits RNA expression. Until now, 6S RNA has not been found in mycobacteria that include important whether M. smegmatis utilizes <...

EE - Mikrobiologie, virologie

  • 2013 - 2018
    • •
  • 2 578 tis. Kč
    • •
  • 2 578 tis. Kč
    • •
  • GA ČR
Project

Novel regulatory RNAs interacting with the transcription machinery in bacteria (GA23-05622S)

Regulatory 6S RNA molecules that interact with RNA polymerase (RNAP) in complex. Our preliminary data show that in addition to 6S/Ms1, other RNAs associate). We propose that 6S RNA and Ms...

Infectious Diseases

  • 2023 - 2025
    • •
  • 10 938 tis. Kč
    • •
  • 10 938 tis. Kč
    • •
  • GA ČR
Project

Regulatory role of small-noncoding RNAs in gene expression (GA310/07/1009)

The goal of the proposed project is the identification of small-noncoding RNAs(ncRNAs), participating in the regulation of gene expression in antibiotic producing bacteria - streptomycetes and determination of their function. The project wil...

CE - Biochemie

  • 2007 - 2011
    • •
  • 6 290 tis. Kč
    • •
  • 6 290 tis. Kč
    • •
  • GA ČR
Project

Structural studies of protein-RNA complexes involved in RNA quality control (GA204/08/1212)

To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings-the leftovers of RNA processing-but also improperly processed ...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 6 990 tis. Kč
    • •
  • 2 490 tis. Kč
    • •
  • GA ČR
Project

Structural studies of protein-RNA complexes involved in RNA quality control (LA08008)

steps of information transfer. RNA maturation involves extensive processing that has a relatively high error rate. Cells have developed an RNA quality control mechanism which identifies improperly processed RNAs and subseq...

CE - Biochemie

  • 2008 - 2010
    • •
  • 1 833 tis. Kč
    • •
  • 1 833 tis. Kč
    • •
  • MŠMT
Project

Structural basis for transcription termination of nonpolyadenylated transcripts (IAA401630903)

RNA polymerases produce RNA transcripts by initiating and terminating RNA transcript. RNA Polymerase II transcribes not only mRNA but also a subset of small nuclear and small nucleoar RNAs, and a class of ...

CE - Biochemie

  • 2009 - 2011
    • •
  • 4 875 tis. Kč
    • •
  • 4 875 tis. Kč
    • •
  • AV ČR
Project

Viral RNA modifications (GJ16-16358Y)

The vitally important methods for the sensitive analysis of RNA modifications enabling detailed studies of the chemical structure of various RNA entities are being developed only recently and they have never been applied to viral

CE - Biochemie

  • 2016 - 2016
    • •
  • 3 895 tis. Kč
    • •
  • 3 895 tis. Kč
    • •
  • GA ČR
Project

The molecular mechanisms of noncanonical 3' terminal RNA tailing and its role in the metabolism of coding and noncoding RNAs (GA20-19617S)

Eukaryotic RNAs undergo a wide variety of posttranscriptional modifications, such as base modifications or nontemplated 3'-end tailing. The 3' terminal RNA uridylation plays diverse roles in RNA metabolism acting in both, p...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 10 824 tis. Kč
    • •
  • 10 806 tis. Kč
    • •
  • GA ČR
Project

Viral RNA modifications – Essential steps in Chemical Evolution of Protein Cofactors (LL1603)

studies, yet, there are surprisingly scarce data on RNA modifications or RNA analysis of RNA modifications enabling detailed studies of the chemical structure of various RNA entities are being developed only recen...

CE - Biochemie

  • 2017 - 2021
    • •
  • 48 762 tis. Kč
    • •
  • 48 762 tis. Kč
    • •
  • MŠMT
Project

Structural dynamics, molecular interactions and function of key RNA motifs (GA203/09/1476)

and function of large RNAs, such as the ribosome. The research will be conducted using of stochastic flexibilities of basic RNA building blocks. Both features are crucial for function of RNAs but are very difficult to asse...

CF - Fyzikální chemie a teoretická chemie

  • 2009 - 2012
    • •
  • 2 812 tis. Kč
    • •
  • 2 812 tis. Kč
    • •
  • GA ČR
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