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14 (0,102s) •

Project

Zinc signaling and metallothioneins sub/isoforms expression in breast cancer implications for prognostic and therapeutic purposes (GC19-13766J)

The project is focused on a detailed study of zinc-dependent signalization and its relation to expression of sub/isoforms of metallothioneins in selected on metallothioneins. In the project, we will study the influence of zinc-deple...

Cell biology

  • 2019 - 2021
    • •
  • 5 339 tis. Kč
    • •
  • 5 339 tis. Kč
    • •
  • GA ČR
Project

Metallothionein analysis in prostate carcinoma at DNA, RNA and protein level. (GP301/09/P436)

metallothionein as a new potential biomarker of tumor diseases specially in prostate carcinoma mechanisms of MT expression. Overexpression of metallothioneins is studied as a new......

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 1 593 tis. Kč
    • •
  • 1 593 tis. Kč
    • •
  • GA ČR
Project

Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein (IAA401990701)

sensitive and rapid detection of DNA and metallothionein will be optimised....

CG - Elektrochemie

  • 2007 - 2011
    • •
  • 2 904 tis. Kč
    • •
  • 2 904 tis. Kč
    • •
  • AV ČR
Project

Influence of metallothionein on binding of platinum cytostatics to DNA in cancer cells (NV15-28334A)

The objective of the project is to study the binding of platinum cytostatics to DNA of human tumor cells (cell lines including chemoresistant ones, tumor samples obtained from patients) and the influences of metallothionein (MT) on this inte...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 15 620 tis. Kč
    • •
  • 15 620 tis. Kč
    • •
  • MZ
Project

Environmental impact assessment and possible pathways and transformations of selected toxic elements in the contaminated area (GA17-00859S)

and their transformations in animal organism (metallothionein synthesis, occurence of methylated element...

DK - Kontaminace a dekontaminace půdy včetně pesticidů

  • 2017 - 2021
    • •
  • 8 888 tis. Kč
    • •
  • 7 835 tis. Kč
    • •
  • GA ČR
Project

The identification of zinc transporters in intestinal epithelial cells, erythropoietic cells and serum (GA204/00/1059)

. The second aim is to elucidate the function of metallothioneins in the cellularzinc...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 1 320 tis. Kč
    • •
  • 1 102 tis. Kč
    • •
  • GA ČR
Project

Characterization of heavy metalbinding proteins in Basidiomycetes (GA204/99/1528)

investigation of induction and properties of a metallothioneine-like proteins, that we have...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 2 478 tis. Kč
    • •
  • 1 650 tis. Kč
    • •
  • GA ČR
Project

Response of plants to abiotic stress by selected heavy metals (GA525/02/0301)

and proline contents will also be followed. Biosynthesis of metallothioneins (MTs...

ED - Fyziologie

  • 2002 - 2004
    • •
  • 3 927 tis. Kč
    • •
  • 1 893 tis. Kč
    • •
  • GA ČR
Project

New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED) (KAN208130801)

of biologically important proteins (p53, p21, metallothionein, glutathion etc.) and sequences...

CG - Elektrochemie

  • 2008 - 2012
    • •
  • 32 657 tis. Kč
    • •
  • 27 753 tis. Kč
    • •
  • AV ČR
Project

Hyperaccumulation of heavy metals in macrofungi - molecular, geomycological and ecotaxonomic aspects (GAP504/11/0484)

encoding metallothioneins and identified transporters. The genus-wide screening...

ED - Fyziologie

  • 2011 - 2015
    • •
  • 9 891 tis. Kč
    • •
  • 9 891 tis. Kč
    • •
  • GA ČR
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