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4 353 (0,101s) •

Project

Rational re-design of microbial enzymes involved in degradation of toxic organic pollutants. (ME 276)

will be conducted using computer modelling. Mutant proteins will be constructed using site-directed mutagenesis techniques. General structure-function relationships......

EB - Genetika a molekulární biologie

  • 1998 - 2002
    • •
  • 3 260 tis. Kč
    • •
  • 1 160 tis. Kč
    • •
  • MŠMT
Project

Expression, site-directed mutagenesis and physical-chemical characterization of the yeast mitochondrial processing peptidase (MPP) (GA204/98/0416)

out site-directed mutagenesis of the active site of yeast MPP; and 3) to clarify of most or all of the leader peptide. Our proposed experiments are directed toward......

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 1 713 tis. Kč
    • •
  • 1 244 tis. Kč
    • •
  • GA ČR
Project

Structure-functional characterization of selected plant aldehyde dehydrogenases (GAP501/11/1591)

and mapping of active-site residues involved in the substrate recognition (supported by experiments of site-directed mutagenesis). Several enzymes will be crystallized......

CE - Biochemie

  • 2011 - 2013
    • •
  • 3 142 tis. Kč
    • •
  • 3 142 tis. Kč
    • •
  • GA ČR
Project

Interaction of bacterial sensor kinase with peptidoglycan subunits and its impact on the cell wall biosynthesis (LH12055)

of its binding with the synthetic ligands. Furthermore, we anticipate to use site-directed mutagenesis and explore that substitution of the amino acids within the binding site for the ligands will result in sensor...

EE - Mikrobiologie, virologie

  • 2012 - 2015
    • •
  • 3 244 tis. Kč
    • •
  • 3 152 tis. Kč
    • •
  • MŠMT
Project

G-domains of elongation factors Tu model proteins for the elucidation of structural elements of thermostability (KJB500520503)

using chimerization and comparative mutagenesis. To elucidate the role of amino acid...

EB - Genetika a molekulární biologie

  • 2005 - 2006
    • •
  • 547 tis. Kč
    • •
  • 547 tis. Kč
    • •
  • AV ČR
Project

Structure-function relationship in maize beta-glucosidase specific for cytokinin glucosides the role of cysteine residues (IAA5004603)

cysteine residues. Here we propose to use site-directed mutagenesis to replace cysteine activitywe will search, by random mutagenesis, for second-site mutations restoring......

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 2 945 tis. Kč
    • •
  • 1 899 tis. Kč
    • •
  • AV ČR
Project

The structure and function of the nicotinic acetylcholine receptor (IAA7011902)

We will use a combination of site-directed mutagenesis and patch clamp each of the ligand binding sites. These experiments should give information about the contribution of each site to channel opening and...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 5 144 tis. Kč
    • •
  • 2 339 tis. Kč
    • •
  • AV ČR
Project

Investigations into regioselectivity of evolved epoxide hydrolases (GAP207/10/0135)

relationships will be approached using directed evolution of the substrate tunnel region of twostructurally different model EHs by iterative saturation mutagenesis and functional structure of a substrate binding site and k...

EI - Biotechnologie a bionika

  • 2010 - 2012
    • •
  • 2 507 tis. Kč
    • •
  • 2 507 tis. Kč
    • •
  • GA ČR
Project

Induction of apoptosis in cancer cells by mitochondria-specific compounds; the role of respiratory complex II (GAP301/12/1851)

inhibitor data indicate that the ubiquinone biding sites play a key role in aTOS interaction, but direct evidence is missing. We will address this issue by site-directed mutagenesis of the proximal ubiqui...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 5 217 tis. Kč
    • •
  • 5 217 tis. Kč
    • •
  • GA ČR
Project

Molecular basis of the 14-3-3 protein-dependent regulation of Ca2+/calmodulin-dependent protein kinase cascade (GA16-02739S)

using site-directed mutagenesis, enzyme activity measurements, analytical direct inhibition through structural modulation of the catalytic site, blocking of dephosphorylation of inhibitory phosphorylation...

EB - Genetika a molekulární biologie

  • 2016 - 2018
    • •
  • 6 963 tis. Kč
    • •
  • 6 573 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 4 353