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966 (0,149s) •

Project

Deciphering the relationship between homologous recombination and gene silencing (GA23-05284S)

is an inherent mechanism of the recombination-dependent replication pathway. We will show that silencing depends on replication fork barriers and occurs primarily during DNA replication. We will also iden...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 7 260 tis. Kč
    • •
  • 7 260 tis. Kč
    • •
  • GA ČR
Project

Regulation of DNA replication - roles of PARP1 and p53 (GJ20-03457Y)

called replication forks. Regulation of replication fork speed and activation of replication fork progression is controlled by multiple mechanisms, including proteins p53 molecular mechanism regu...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 7 962 tis. Kč
    • •
  • 7 962 tis. Kč
    • •
  • GA ČR
Project

Role of RECQ5 DNA helicase in maintenance of genomic stability (GA204/09/0565)

DNA replication forks often pause upon encounter of DNA damage in the DNA replication forks and restore the replication process. However, the molecular mechanisms is required for reactivation of damaged

EB - Genetika a molekulární biologie

  • 2009 - 2013
    • •
  • 8 570 tis. Kč
    • •
  • 8 570 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms involved in reactivation of replication forks stalled by co-transcriptional R-loops (GA22-08294S)

replication stress and genomic instability, hallmarks of cancer. Our recent study revealed that replication fork reversal induced by R-loops is followed by the restart transcription complexes at TRC sites can resume RNA sy...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 986 tis. Kč
    • •
  • 9 986 tis. Kč
    • •
  • GA ČR
Project

Exploring mechanisms of DNA replication restart upon collisions between transcription and replication complexes (GA19-07674S)

, understanding of how a replication fork restarts DNA synthesis upon a TRC remains elusive of proteins at restarting replication forks, which will allow their isolation analysis to decipher their roles in the reac...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 10 396 tis. Kč
    • •
  • 9 563 tis. Kč
    • •
  • GA ČR
Project

Identification and characterization of proteins involved in G-quadruplex and R-loop metabolism and their relationship with DNA replication (GX21-22593X)

as well as relationship to replication fork progression and associated repair.DNA replication is an essential and one of the most complex processes replication obstacles with possible detrimental effects on genome...

Biochemistry and molecular biology

  • 2021 - 2025
    • •
  • 49 901 tis. Kč
    • •
  • 49 901 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms involved in removing R-loops at sites of interference between DNA transcription and replication (GA25-15542S)

of tumorigenesis. We discovered that replication forks blocked by R-loops can be reactivatedTranscription-replication conflicts caused by co-transcriptional RNA:DNA mechanisms responsible for removing R-loops at sites of R...

Biochemistry and molecular biology

  • 2025 - 2027
    • •
  • 11 342 tis. Kč
    • •
  • 11 342 tis. Kč
    • •
  • GA ČR
Project

Role of Nse proteins, subunits of the SMC5/6 complex, in stabilization and processing of stalled replication forks (GA13-00774S)

The SMC5/6 complexes are implicated in many processes like chromosome segregation, DNA repair, stabilization and restart of stalled replication forks (RF). They are composed of 6 conserved polypeptides, of which Nse1, Nse3 and Nse4 ...

CE - Biochemie

  • 2013 - 2016
    • •
  • 7 346 tis. Kč
    • •
  • 7 346 tis. Kč
    • •
  • GA ČR
Project

Deciphering Origins of DNA replication in genome integrity (GM22-20303M)

DNA replication is fundamental to cell proliferation, but its malfunctions can cause genome instability and trigger diseases including cancer. DNA replication initiates at replication origins by the formation of pre-rep...

Cell biology

  • 2022 - 2026
    • •
  • 24 928 tis. Kč
    • •
  • 24 928 tis. Kč
    • •
  • GA ČR
Project

Study of molecular mechanisms involved in suppression of transcription-associated genomic instability (GA17-02080S)

of replication forks, especially under conditions of replication stress that is induced of collisions between transcription and replication complexes. To advance understanding of yet ill-defined molecular mechanis...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 9 174 tis. Kč
    • •
  • 7 836 tis. Kč
    • •
  • GA ČR
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