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16 (0,129s) •

Project

Dynamics of Spliceosome assembly (IAA5039103)

of fluorescent fusion proteins corresponding to protein components of spliceosome for spliceosome assembly. Fusion proteins will be introduced as expression vectors introduced......

EA - Morfologické obory a cytologie

  • 2001 - 2005
    • •
  • 3 336 tis. Kč
    • •
  • 1 708 tis. Kč
    • •
  • AV ČR
Project

Identification and characterization of a new pathway regulating pre-mRNA splicing (GX23-04754X)

, which co-transcriptionally undergo intron excision by the spliceosome, a megadalton RNA-protein complex. Spliceosome activation is a major, but poorly characterized identified a new pathway that controls spliceosome activ...

Biochemistry and molecular biology

  • 2023 - 2027
    • •
  • 49 981 tis. Kč
    • •
  • 49 981 tis. Kč
    • •
  • GA ČR
Project

Formation of splicing machinery in the context of the cell nucleus (GAP302/11/1910)

). Specifically, we plan to identify signals that target spliceosomal snRNPs in to the CB and integrity. In parallel, we propose to address the dynamics of spliceosome assembly in vivo and determine how inhibition of spliceosome...

EA - Morfologické obory a cytologie

  • 2011 - 2014
    • •
  • 6 045 tis. Kč
    • •
  • 6 045 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanism of spliceosomal snRNP formation (GA21-04132S)

Small nuclear ribonucleoprotein (snRNP) particles are key components of the spliceosome that catalyzes pre-mRNA splicing. The biogenesis of snRNP particles takes place in several steps, and errors in their formation are behind some hereditar...

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 9 023 tis. Kč
    • •
  • 9 023 tis. Kč
    • •
  • GA ČR
Project

Functional analysis of hBrr2 mutations linked to retinitis pigmentosa (GPP301/12/P425)

by a ribonucleoprotein complex, the spliceosome. Here, we propose to focus on human splicing factor hBrr2 mutants on spliceosome assembly and function. In addition, we propose to study......

EB - Genetika a molekulární biologie

  • 2012 - 2018
    • •
  • 2 326 tis. Kč
    • •
  • 2 326 tis. Kč
    • •
  • GA ČR
Project

Characterising the regulatory mechanisms at decoy 5’ splice sites (GF24-11219K)

sequences of 5’ splice sites and assemble some spliceosomal components. We will assess the proportion of d-5’ss that assemble non-productive spliceosomal complexes, which compete......

Genetics and heredity (medical genetics to be 3)

  • 2024 - 2027
    • •
  • 8 364 tis. Kč
    • •
  • 8 329 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of nuclear structure formation (LTAUSA18103)

In the current project we aim to enhance our understanding of basic molecular principles that govern formation of nuclear structures. We will specifically focus our effort on nuclear Cajal bodies and test a hypothesis that formation of Cajal body is ...

Cell biology

  • 2019 - 2022
    • •
  • 5 459 tis. Kč
    • •
  • 5 459 tis. Kč
    • •
  • MŠMT
Project

The mechanism whereby the novel coactivator SNW regulates gene expression (GA204/02/1512)

with one of the spliceosomal auxiliary factors, and in D. discoideum with a novel type...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 4 855 tis. Kč
    • •
  • 3 055 tis. Kč
    • •
  • GA ČR
Project

Principles of snRNP sequestration into cellular structures (GA18-10035S)

Small nuclear ribonucleoprotein particles (snRNPs) are the key components of the spliceosome that catalyze pre-mRNA splicing. Assembly of snRNPs is a multistep process and mistakes in snRNP formation cause several hereditary diseases e.g. de...

Cell biology

  • 2018 - 2020
    • •
  • 7 865 tis. Kč
    • •
  • 7 376 tis. Kč
    • •
  • GA ČR
Project

Spliceosomal snRNP assembly and surveillance in Drosophila melanogaster (LH14033)

The main aim of this project is to characterize and compare key mechanisms that control formation of snRNPs in human and fruit fly. We will mainly concentrate on newly imported snRNPs to the nucleus and the role of coilin and Cajal bodies in final st...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 1 769 tis. Kč
    • •
  • 1 769 tis. Kč
    • •
  • MŠMT
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