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33 (0,208s) •

Project

Study of structural and binding properties of TRPM channels (GA17-04236S)

stimuli. Phosphatidylinositol–4,5-bisphosphate (PIP2) is a intracellular messenger diversity of PIP2 effector proteins allow PIP2 signaling to control a broad range of cellular functions. TRP cha...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2018
    • •
  • 4 246 tis. Kč
    • •
  • 3 747 tis. Kč
    • •
  • GA ČR
Project

Contribution of (pre)lamin A - phosphoinosites complexes to intranuclear order. (GA16-03346S)

and a phosphoinositide phosphatidylinositol 4,5-bisphosphate. In this project, we plan...

EA - Morfologické obory a cytologie

  • 2016 - 2018
    • •
  • 9 051 tis. Kč
    • •
  • 8 349 tis. Kč
    • •
  • GA ČR
Project

Study of the interaction of C- and N- terminal segments of TRPV1 and TRPV3 channels with phospholipids. (GPP205/10/P308)

by a wide range of different stimuli. Recently phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) have been found to function as an important regulator of TRP ion channels.  The main goal of this project is to stud...

BO - Biofyzika

  • 2010 - 2012
    • •
  • 1 218 tis. Kč
    • •
  • 1 218 tis. Kč
    • •
  • GA ČR
Project

Advanced correlated light and electron microscopy as a tool for studying novel nuclear structures and their impact on the gene transcription and global nuclear architecture (LTC19048)

Aims of the project: 1. Development of a method for correlative super-resolution light and transmission electron microscopy (CLEM) for characterization of lipid islets (NLI) in the cell nucleus. 2. Study of ultrastructure, composition and close neigh...

Cell biology

  • 2019 - 2022
    • •
  • 8 308 tis. Kč
    • •
  • 8 308 tis. Kč
    • •
  • MŠMT
Project

Multiscale analysis of signalling phospholipids and their interaction protein partners in the regulation of plant tip growth (GA13-19073S)

) and phosphatidylinositol 4,5-bisphosphate (PIP2) control cell polarity and vesicular trafficking in non in cooperation with PIP2 as localization cues, which recruit their effector proteins and PIP2

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 7 272 tis. Kč
    • •
  • 7 272 tis. Kč
    • •
  • GA ČR
Project

Functional modulation of chromatin-modifying enzymes by nuclear phosphoinositides (GA17-09103S)

that phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) associates with transcription factor UBF PIs. Specifically, as our preliminary data revealed that PI(4,5)P2 interacts......

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 9 384 tis. Kč
    • •
  • 8 589 tis. Kč
    • •
  • GA ČR
Project

Phosphoinositide compartments in the cell nucleus structure and function (GA15-08738S)

- phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) - promotes rDNA transcription and contributes their particular functions. Our preliminary data revealed that PI(4,5)P2 forms discrete foci......

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 9 918 tis. Kč
    • •
  • 9 918 tis. Kč
    • •
  • GA ČR
Project

Good-Cop/Bad-Cop Distinct roles of anionic phospholipids in plant endocytosis (GA19-21758S)

Endocytosis is crucial process in the establishment and maintenance of cell polarity. Minor anionic phospholipids are key regulators of clathrin-mediated endocytosis (CME) with phosphatidylinositol 4,5-bisphosphate playing ...

Cell biology

  • 2019 - 2022
    • •
  • 7 356 tis. Kč
    • •
  • 7 356 tis. Kč
    • •
  • GA ČR
Project

Functions of lamin A - phosphoinositides complexes in the cell nucleus. (GA19-05608S)

with phosphatidylinositol 4,5-bisphosphate exhibiting different mechanism of binding and different...

Cell biology

  • 2019 - 2021
    • •
  • 9 982 tis. Kč
    • •
  • 9 637 tis. Kč
    • •
  • GA ČR
Project

Structural and functional determinants on TRPV channels (GAP301/10/1159)

and phosphatidyl inositol-4,5-bi-phosphate (PIP2). The aims are: to determine binding sites of TRPV4 and binding sites for PIP2 in TRPV2,3,4,6 in both N- and C-tails and in N......

CE - Biochemie

  • 2010 - 2014
    • •
  • 5 130 tis. Kč
    • •
  • 5 130 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 33