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3 247 (0,091s) •

Project

Toll-like receptors in prostate carcinogenesis and therapy resistance (NV17-28518A)

. In the present translational project we will examine the role of toll-like receptors in regulation of cellular events associated with resistance. Toll-like receptors carcinogenesis has also been...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 14 546 tis. Kč
    • •
  • 14 531 tis. Kč
    • •
  • MZ
Project

Influence of Toll-like Receptor Agonists on Immunogenicity of Tumour Cells in B cell Chronic Lymphocytic Leukemia (GP310/08/P353)

approaches to this disease. Non-malignant B cells express broad spectrum of Toll-like receptors, evolutionarily conserved proteins that recognize microbial molecules-presentation functions. In this project we will study ef...

EC - Imunologie

  • 2008 - 2010
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • GA ČR
Project

Functional characteristics of circulating dendritic cells in patients with X-linked agammaglobulinemia (NS10489)

the crucial role of Toll-like receptors in the recognition of pathogens, we will study thefunction of all identified Toll like receptors on myeloid and plasmacytoid DC subsets......

EC - Imunologie

  • 2009 - 2011
    • •
  • 5 717 tis. Kč
    • •
  • 5 717 tis. Kč
    • •
  • MZ
Project

Molecular and cellular mechanisms in ethiopathogenesis of nasal polyposis (NS10054)

Signaling pathways and changes in expression of intracellular signaling molecules in nasal polyps. Expression of Toll-like receptors as potential markers for identifying etiological environmental factors in nasal polyps. Ch...

FF - ORL, oftalmologie, stomatologie

  • 2008 - 2011
    • •
  • 2 140 tis. Kč
    • •
  • 2 140 tis. Kč
    • •
  • MZ
Project

Antimicrobial peptides and Toll-like receptors in ontogeny and bacterial infections. (GA524/09/0365)

Antimicrobial peptides (AMPs) are endogeneous substances protecting organisms against infection. Basic knowledge of them and possibility of their induction is needed due to  increasing resistance of pathogenic bacteria against classical microbial ant...

EC - Imunologie

  • 2009 - 2014
    • •
  • 5 860 tis. Kč
    • •
  • 5 860 tis. Kč
    • •
  • GA ČR
Project

Importance of Toll-like receptors in intestinal epithelium response to cyanobacterial water bloom (GA16-24949S)

on the interaction of microcystins with Toll-like receptors (TLRs). Interestingly, altered...

DN - Vliv životního prostředí na zdraví

  • 2016 - 2020
    • •
  • 6 733 tis. Kč
    • •
  • 6 475 tis. Kč
    • •
  • GA ČR
Project

The role of innate immune molecules in embryonic homeostasis and sterile inflammation (IAA500520707)

Toll-like receptors (TLRs) are involved in infectious inflammation through the recognition of microbial structures. TLRs also appear to recognize endogenous ligands-receptor CD14 on embryonic phagocytes suggesting ...

EC - Imunologie

  • 2007 - 2011
    • •
  • 4 832 tis. Kč
    • •
  • 4 832 tis. Kč
    • •
  • AV ČR
Project

The role of Toll-like receptor signaling in the mechanism of central tolerance (GA19-23154S)

of chemokines and their receptor(s) that mediate signaling between mTECs and DCs in the thymus to enhance CAT under Toll-like receptor-stimulatory conditions a self-reactive T cell antigen receptor or the...

Immunology

  • 2019 - 2021
    • •
  • 8 619 tis. Kč
    • •
  • 8 178 tis. Kč
    • •
  • GA ČR
Project

Polymer vaccines novel high potent immunostimulants for infectious disseases treatment (GJ16-14957Y)

Safe and efficient vaccine requires, except an antigen, using of the immunostimulatory agents, so called adjuvants. Toll-like receptor (TLR) agonists, expressed receptors. Therefore, we propose a solution consistin...

CD - Makromolekulární chemie

  • 2016 - 2018
    • •
  • 4 624 tis. Kč
    • •
  • 4 624 tis. Kč
    • •
  • GA ČR
Project

The role of prolactin in immune response to bacterial infection (NS9970)

cortisol by Toll-like receptors (TLRs) activation. The family of TLRs is critical...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 5 226 tis. Kč
    • •
  • 5 226 tis. Kč
    • •
  • MZ
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