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102 (0,089s) •

Project

Molecular mechanism of apoptosis induced by alfa-tocopheryl succinate in cancer cells. (KJB500970904)

alfa-Tocopheryl succinate (alfa-TOS) is a selective inducer of apoptosis cascades and molecules responsible for this pro-apoptotic effect of alfa-TOS in cancer upregulated in cancer cells after alfa

EB - Genetika a molekulární biologie

  • 2009 - 2010
    • •
  • 971 tis. Kč
    • •
  • 971 tis. Kč
    • •
  • AV ČR
Project

Induction of apoptosis in cancer cells by mitochondria-specific compounds; the role of respiratory complex II (GAP301/12/1851)

Redox-silent vitamin E (VE) analogues, such as alpha-tocopheryl succinate (aTOS), eliminate cancer cells by mitochondrially-mediated apoptosis. Respiratory complex II (CII), which converts succinate to fumarate in the Krebs...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 5 217 tis. Kč
    • •
  • 5 217 tis. Kč
    • •
  • GA ČR
Project

Cell death pathways in mesothelioma cells exposed to pharmacological and immunological inducers of apoptosis genomic and proteomic approach (IAA500520602)

Management of neoplastic diseases is one of the greatest challenges of medicine. Amongst the most difficult cancers are malignant mesotheliomas (MM) with no current treatment. Vitamin E analogues, epitomised by alpha-tocopheryl succinate...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 3 196 tis. Kč
    • •
  • 3 196 tis. Kč
    • •
  • AV ČR
Project

Mitochondrial respiratory complex II deficiency in cancer development (GA17-20904S)

Respiratory complex II (CII) deficiency leads to cancer, with reactive oxygen species (ROS) and increased succinate suggested as causal agents. For unclear reasons subunits on an identical genetic background. We will measure ROS and succ...

CE - Biochemie

  • 2017 - 2019
    • •
  • 5 724 tis. Kč
    • •
  • 5 724 tis. Kč
    • •
  • GA ČR
Project

Development of active, intelligent and sustainable food PACKaging using PolybutyleneSUCCInate, SUCCIPACK (7E12027)

SUCCIPACK aims to support European industry efforts to introduce biobased polybutylene succinate (PBS) as a new material on the food packaging market. Its main advantage is that it has complementary properties compared to other biobased poly...

GM - Potravinářství

  • 2012 - 2014
    • •
  • 1 011 tis. Kč
    • •
  • 1 011 tis. Kč
    • •
  • MŠMT
Project

New inhibitors of alfa-amylases as potential compounds in medicine and agriculture (GP203/02/P081)

The project is focused on selected alfa-amylases associated with important by action of specific alfa-amylase inhibitors. The aim of the project is design oflow-molecular weight inhibitors of alfa-alylases with the use of t...

CE - Biochemie

  • 2002 - 2004
    • •
  • 742 tis. Kč
    • •
  • 605 tis. Kč
    • •
  • GA ČR
Project

The role of PPAR-alfa in the regulation of insulin sensitivity. (NB7429)

The aim of the project is to study the role of PPAR-alfa in the regulation of glucose metabolism and insulin sensitivity. Euglycemic-hyperinsulinemic clamp will be used to measure the changes of insulin sensitivity in patients with insulin w...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 3 134 tis. Kč
    • •
  • 3 035 tis. Kč
    • •
  • MZ
Project

Molecular dynamic simulations of damage in alfa-iron and influence of impurities (IAA2076701)

and 3D, equilibrium atomic structure of nano-scale precipitates embedded in alfa-iron - precipitate, further radiation damage and dislocation pinning in alfa-iron containing......

BM - Fyzika pevných látek a magnetismus

  • 1997 - 2001
    • •
  • 1 682 tis. Kč
    • •
  • 838 tis. Kč
    • •
  • AV ČR
Project

Retinoic acid nuclear receptor alfa rearrangements in retinoid induced differentiation of leukemic cells. (IZ2819)

FD - Onkologie a hematologie

  • 1995 - 1997
    • •
  • 1 346 tis. Kč
    • •
  • 1 346 tis. Kč
    • •
  • MZ
Project

Transport processes during heat treatment in Mg-Al alloys (GA106/03/1355)

The aim of the present project is to study diffusion processes in Mg alloys of the Mg-Al type. Measurements will be carried out in three model Mg-Al based materials (alfa, ß, eutectic) and in commercial AZ91 alloy. Coefficients of volume dif...

BJ - Termodynamika

  • 2003 - 2005
    • •
  • 6 081 tis. Kč
    • •
  • 2 881 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 102