All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

42 (0,196s) •

Project

Spatiotemporal transcriptome and proteome analysis of α-Synuclein pathology in Parkinson’s disease Identification of cell type-specific vulnerability and tolerance mechanisms (9F24003)

1. Spatiotemporal analysis of neuronal, glial and immune cell responses at transcriptome and proteome level in vulnerable and more resistant brain regions; 2. Multi-omic bioinformatics analysis of spatiotemporal gene and protein expression changes, s...

Other medical science

  • 2024 - 2027
    • •
  • 6 633 tis. Kč
    • •
  • 6 633 tis. Kč
    • •
  • MŠMT
Project

New strategy for inhibition of amyloid fibril formation (GJ18-06255Y)

Misfolding of the protein alpha-synuclein is the key step in the development autocatalytic prion-like process. Currently available methods for preventing alpha-synuclein that either bind and stabilize native form of alpha-synucl...

Biophysics

  • 2018 - 2021
    • •
  • 5 695 tis. Kč
    • •
  • 5 695 tis. Kč
    • •
  • GA ČR
Project

Novel peptide‐based aggregation inhibitors as potential therapeutics for neurodegenerative diseases (8X25063)

with Aβ40 and α-Syn antiaggregation potential to promote the development of novel) Structural characterization of the selected 4 LEAPs with potential to inhibit α-Syn and Aβ40 aggregation. (ii)Defining the Aβ40/LEAPs and α...

Biophysics

  • 2025 - 2027
    • •
  • 246 tis. Kč
    • •
  • 246 tis. Kč
    • •
  • MŠMT
Project

Exploring α-L-rhamnosyl-β-D-glucosidases — emerging enzymes in food chemistry (GA19-00091S)

Rutin and hesperidin-containing byproducts are generated in the fruit-processing and agro-industry on a very large scale. α-L-Rhamnosyl-β-D-glucosidases will investigate the relationships between the structure, function and promiscuity of fo...

Agricultural biotechnology and food biotechnology

  • 2019 - 2023
    • •
  • 4 411 tis. Kč
    • •
  • 4 411 tis. Kč
    • •
  • GA ČR
Project

Interfacial properties of alpha-synuclein and aggregation of this protein in Parkinson's disease (KJB100040901)

Parkinson's disease is the second most common neurodegenerative disease that affects coordination of movement in sufferers, associated with the formation and deposition of amyloid fibrils of the protein alpha-synuclein (AS). Studies of AS ag...

BO - Biofyzika

  • 2009 - 2011
    • •
  • 1 620 tis. Kč
    • •
  • 1 620 tis. Kč
    • •
  • AV ČR
Project

Synucleinopathy - gut microbiota, pathophysiology, and biomarkers of progression (NW25-04-00079)

by pathological synuclein inclusions in nervous tissue. The manifestation of PD and DLB of the two pathways by which synuclein spreads in the body begins in the enteric synuclein species or whether this microbiota can cont...

Neurosciences (including psychophysiology)

  • 2025 - 2028
    • •
  • 18 857 tis. Kč
    • •
  • 18 857 tis. Kč
    • •
  • MZ
Project

Redox and photochemical properties of polypyridyl-based biosensors (GN23-05760O)

substituted complexes with ruthenium (II) or chromium (III) will be synthesized – tris(α-diimine) complexes in the form of Cl or PF6 salts, bis(α-diimine) complexes with two NCS probes and their DNA analogs. Several structural type...

Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

  • 2023 - 2026
    • •
  • 3 650 tis. Kč
    • •
  • 3 650 tis. Kč
    • •
  • GA ČR
Project

Utilizing CD64-specific synthetic antibody mimetics for cancer immunotherapy and immunomodulation (LUAIZ24161)

-specific copolymer, α-CD64 iBody, modified with a cyclic peptide binding to CD64 and a fluorescent tag for visualization. Additionally, α-CD64 iBody can include another ligand response. We plan to develop cytotoxic synthetic copoly...

Immunology

  • 2024 - 2027
    • •
  • 3 150 tis. Kč
    • •
  • 2 500 tis. Kč
    • •
  • MŠMT
Project

3-Nitro-L-tyrosine in structures of neurodegenerative proteins (GA14-00431S)

and alpha-synuclein models. The first one plays role in transmissible spongiform...

CF - Fyzikální chemie a teoretická chemie

  • 2014 - 2016
    • •
  • 4 344 tis. Kč
    • •
  • 4 344 tis. Kč
    • •
  • GA ČR
Project

Biophysical properties of Lipid Droplets and their implications in Gaucher disease and Parkinsons disease (EH22_010/0008585)

between GD and PD. LD accumulation was observed to increase toxic α-Syn aggregates in both PD and GD models. Additionally, a direct binding of α-Syn to LD has been that the biophysics/composition of LD influences the α-Syn...

Biophysics

  • 2024 - 2026
    • •
  • 3 904 tis. Kč
    • •
  • 987 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 42