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3 451 (0,132s)

Project

Comparative study of Huntingtons disease bioenergetics functions of mitochondria in patients and in transgenic minipigs (LD15099)

1)To study impact of HD on mitochondrial energetic metabolism in the cells of peripheral tissues of patients with Huntington disease 2) to characterize impact HD on mitochondrial energetic metabolism in the cells of peripheral tissu...

CE - Biochemie

  • 2015 - 2017
  • 1 522 tis. Kč
  • 1 522 tis. Kč
  • MŠMT
Project

Proteomic analysis of extracellular vesicles in Huntington's disease (GA19-01747S)

Huntington’s disease is inherited incurable neurodegenerative disease caused of Huntington’s disease and to compare levels of selected proteins with EVs isolated from of mutant huntingtin production to pos...

Neurosciences (including psychophysiology)

  • 2019 - 2022
  • 9 821 tis. Kč
  • 9 518 tis. Kč
  • GA ČR
Project

Biomedical model of miniature pigs for testing of new medicaments and for new treatments of traumatic spinal cord injury and neurodegenerative diseases (TA01011466)

injury and Huntington disease in miniature pigs. We want to achieve the objective, to prepare the acute and transgenic models of Huntington disease via application......

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2014
  • 22 639 tis. Kč
  • 18 033 tis. Kč
  • TA ČR
Project

Huntington disease-correlationbetwoen trinucleotide ( CAG ) repetition and clinical features of the disease. (IZ3146)

FG - Pediatrie

  • 1995 - 1997
  • 950 tis. Kč
  • 902 tis. Kč
  • MZ
Project

The experimental model of Huntington's disease The reaction of the subependymal layer of lateral ventricles to neurodegenerative process within the striatum, and to the fetal neural graft. (NF7594)

The therapy of Huntington's disease is very limited at the present time. Neural grafting is now the only therapeutic approach which provides a reduction of symptoms in most of the patients, but only temporarily. It seems that stimul...

EA - Morfologické obory a cytologie

  • 2003 - 2005
  • 2 557 tis. Kč
  • 2 476 tis. Kč
  • MZ
Project

Autophagy in pathogenesis of Huntington's disease (GA22-24983S)

Huntington’s disease (HD) is a deadly hereditary neurodegenerative disorder, caused by an expansion of CAG tract in the huntingtin gene (HTT) over 36 repeats. Expanded stretch of glutamines at the N-terminus of HTT protein changes i...

Cell biology

  • 2022 - 2024
  • 9 027 tis. Kč
  • 9 027 tis. Kč
  • GA ČR
Project

Huntington´s disease Analysis of relation between clinical, functional and morphometric parameters. (NF7623)

40 HD patients will be clinically investigated, the MRI based voxel-wise volumometric analysis of basal ganglia and frontal lobes and depositions of iron will be analysed. 40 healthy volunteers will be used as a control group. All HD patients will be...

FH - Neurologie, neurochirurgie, neurovědy

  • 2003 - 2005
  • 2 128 tis. Kč
  • 2 128 tis. Kč
  • MZ
Project

Influence of Rehabilitation on Gait and Balance Disorders in Neurodegenerative Diseases Affecting Basal Ganglia (NV17-32318A)

This project is focused on an objective evaluation of the effect of different rehabilitation programs on postural instability and gait disturbances in patients with Huntington's disease (HD) and Parkinson's disease (PD). Pa...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2021
  • 7 204 tis. Kč
  • 7 158 tis. Kč
  • MZ
Project

ExAM Experimental Animal Models (ED2.1.00/03.0124)

, Huntington disease and human melanoma. The effective cooperation of all three Research preparation of biomedical models of diseases. The principal objective of the Research program is to contribute to basic understanding ...

EB - Genetika a molekulární biologie

  • 2012 - 2015
  • 174 556 tis. Kč
  • 26 184 tis. Kč
  • MŠMT
Project

Diagnostic and progressive potential of speech dual-tasking in basal ganglia disorders evidence from Parkinson's disease and Huntington's disease (NW25-04-00052)

in up to 90% of patients with basal ganglia disorders such as Parkinson's disease (PD) and Huntington's disease (HD). Speech impairment can occur since the prodromal stages and becomes more severe as the disease p...

Clinical neurology

  • 2025 - 2028
  • 10 344 tis. Kč
  • 10 344 tis. Kč
  • MZ
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