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57 (0,097s) •

Project

Analysis of WNT/PCP pathway for better management of chronic lymphocytic leukemia (NV15-29793A)

Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults of the crucial molecular pathways associated with pathogenesis of CLL is Wnt/PCP signaling in CLL and can distinguish individual subgroups of C...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 937 tis. Kč
    • •
  • 9 937 tis. Kč
    • •
  • MZ
Project

Analysis of tumour-reactive gamma/delta T cells in patients with B-cell chronic lymphocytic leukaemia a new approach to the cellular therapy (NV15-32935A)

(??) T cells in patients with chronic lymphocytic leukemia (CLL). Human ?? T cells cells against primary CLL cells but the detailed analysis of ?? expansions, clonality and anti-CLL reactivity are currently missing. In add...

EC - Imunologie

  • 2015 - 2018
    • •
  • 8 537 tis. Kč
    • •
  • 8 537 tis. Kč
    • •
  • MZ
Project

Encyclopedia of CLL Subsets a unique knowledgebase and novel bioinformatics tools towards personalised biomedical and clinical applications (NV16-34272A)

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia be identified in one out of three CLL patients – leading to their inclusion in subsets of cases, or CLL subsets, with intriguing homogeneity in clinical p...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 8 954 tis. Kč
    • •
  • 8 954 tis. Kč
    • •
  • MZ
Project

Predictive stratification of CLL patients for therapy involving monoclonal antibodies targeting CD20 antigen (NV16-32743A)

Chronic lymphocytic leukemia (CLL) still represents incurable disease of therapeutic response in CLL patients. There are, however, still problems is to establish a system for the prediction of treatment response in CLL pati...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 7 664 tis. Kč
    • •
  • 7 664 tis. Kč
    • •
  • MZ
Project

In vitro sensitivity/resistance of CLL cells with inactivated p53 on modern therapy (NR8445)

CLL is uncurable disease and the cases with the worst prognosis (especially with regard to treatment) are the patients with inactivated p53 tumor-supressor. Whether. In vitro tests performed on freshly isolated B-CLL cells with exac...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 710 tis. Kč
    • •
  • 1 648 tis. Kč
    • •
  • MZ
Project

Clonal expansions in chronic lymphocytic leukemia – (epi)genomic characterization towards better disease understanding (NW24-03-00052)

lymphocytic leukemia (CLL) through the systematic examination of its multiclonal form. CLL with multiclonal CLL in which several B-cell clones with unrelated immunoglobulin receptors the premalignant phase and overt CL...

Oncology

  • 2024 - 2027
    • •
  • 15 347 tis. Kč
    • •
  • 15 347 tis. Kč
    • •
  • MZ
Project

THE ROLE OF TRANSCRIPTION FACTORS IN AGGRESSIVENESS AND RESISTANCE TO TARGETED THERAPY IN CHRONIC LYMPHOCYTIC LEUKEMIA (NW24-03-00369)

in chronic lymphocytic (CLL) cells, such as activation of B-cell receptor signaling (BCR) and T-CLL cell interactions. Approval of microenvironment-targeting strategies revolutionized CLL therapy. Subsequently, genetic res...

Cell biology

  • 2024 - 2027
    • •
  • 15 475 tis. Kč
    • •
  • 15 475 tis. Kč
    • •
  • MZ
Project

DEVELOPMENT OF MODELS FOR THE STUDIES OF MICROENVIRONMENT AND THERAPEUTIC RESISTANCE IN B CELL MALIGNANCIES (NU23-08-00448)

The biology of chronic lymphocytic leukemia (CLL) and other "indolent" mature B cell malignancies largely depends on microenvironmental interactions. CLL cells do aggressiveness. Moreover, CLL cells will not permanently eng...

Hematology

  • 2023 - 2026
    • •
  • 11 906 tis. Kč
    • •
  • 11 906 tis. Kč
    • •
  • MZ
Project

Single cell analysis a modern tool to study clonal evolution in high-risk patients with chronic lymphocytic leukemia (NU20-08-00314)

on chronic lymphocytic leukemia (CLL). In this study, we would like to profound our knowledge to better understand the mechanisms underlying clonal evolution of CLL cells of CLL. In particular, we will analyse and compare ...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2020 - 2023
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  • 11 736 tis. Kč
    • •
  • 11 736 tis. Kč
    • •
  • MZ
Project

Analysis of clonal heterogeneity in chronic lymphocytic leukemia using next generation sequencing of B cell receptor. A national study. (NV15-30015A)

Chronic lymphocytic leukemia (CLL) is characterized by extraordinary stimulation operation in CLL, which is also supported by epidemiological studies. High and delve into extensive immunogenetic sequence datasets in CLL. Fu...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 15 351 tis. Kč
    • •
  • 15 028 tis. Kč
    • •
  • MZ
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