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19 (0,222s) •

Project

Improvement of molecular diagnostics of congenital adrenal hyperplasia (CAH) (NR9308)

The aim of the project is to improve present DNA diagnostics of congenital adrenal hyperplasia (CAH) in the Czech Republic. By study of CYP21 and CYP21P genes with using of techniques such as MLPA, LR PCR, gene walking, DHPLC and sequencing ...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 3 985 tis. Kč
    • •
  • 3 736 tis. Kč
    • •
  • MZ
Project

Limited adipose tissue expandability as a risk factor for development of type 2 diabetes the role of preadipocytes (LIMEX) (GA16-14048S)

Adipose tissue (AT) expands in response to excessive energy intake by hyperplasia or hypertrophy. While hyperplasia is associated with preservation of insulin hyperplasia is suppressed at the expense of AT hypertrophy remai...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2016 - 2020
    • •
  • 6 897 tis. Kč
    • •
  • 6 897 tis. Kč
    • •
  • GA ČR
Project

The Assesment of Effectivity of the Neonatal Screening for Congenital Adrenal hyperplasia in the Czech republic. (NE6133)

The assement of effectivity of the neonatal screening for congenital adrenal hyperplasia in the conditions of the Czech Republic,The screening is based on the measurement of the level of 17-alfa-hydroxyprogesterone in the dried blood spot......

FG - Pediatrie

  • 2000 - 2002
    • •
  • 3 262 tis. Kč
    • •
  • 3 262 tis. Kč
    • •
  • MZ
Project

Apoptotic changes in endometrial proliferation (NR9313)

Isufficient apoptosis is one of the causal factors of cancerogenesis and oncological treatment failure. Expression of apoptotic inhibitors has been proven in many human malignancies. The aim of this project is to detect the apoptotic changes in diffe...

FK - Gynekologie a porodnictví

  • 2007 - 2009
    • •
  • 2 627 tis. Kč
    • •
  • 2 584 tis. Kč
    • •
  • MZ
Project

Analysis of CYP21 genes in newborns with mild elevated 17-hydroxyprogesterone level. (NS9981)

The aim of this project is to analyse 21-hydroxylase genotypes in newborns with mild elevated 17-hydroxyprogesteron concentration in newborn screeening (NS) for congenital adrenal hyperplasia (CAH) and to verify the hypothesis, that the geno...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 2 729 tis. Kč
    • •
  • 2 722 tis. Kč
    • •
  • MZ
Project

The prevention of intimomedial hyperplasia in vascular anastomoses (ND4838)

To prevent the transfer of vibrations due to a blood- flow turbulence through a smooth vascular wall on surrounding tissue a specialy designed, rigid, non- thrombogenic stent is instroduce into an anastomosis.......

FJ - Chirurgie včetně transplantologie

  • 1998 - 1999
    • •
  • 2 384 tis. Kč
    • •
  • 2 157 tis. Kč
    • •
  • MZ
Project

The Estrogen Stress Response in the Elderly Man and Its Possible Influence on the Development of the Benign Prostate Hyperplasia (BPH) and on the Prostate Cancer (CaP). (NB7613)

To exclude or to confirm that the older men have a quantitatively higher estrogen response after ACTH (stress). To exclude or to confirm that the patients with a more pronounced estrogen ACTH (stress) response in their older years, have a lower incid...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 751 tis. Kč
    • •
  • 680 tis. Kč
    • •
  • MZ
Project

Improvement of non-invasive stenosis diagnostics will prolong patency of artificial hemodialysis shunts (NK6000)

Artificial hemodialysis shunts suffer from intimal hyperplasia.Its in-time diagnostics will lead to prolongation of shunt patency and lower the financial costs.......

FP - Ostatní lékařské obory

  • 2000 - 2002
    • •
  • 650 tis. Kč
    • •
  • 648 tis. Kč
    • •
  • MZ
Project

Polymorphism of the androgen receptor gene (SNP rs6152) relationship to expression of the androgen-sensitive genes in benign prostatic hyperplasia, carcinoma of the prostate and androgenetic (NS9940)

The below mentioned hypotheses will be tested using appropriate prospective as well as retrospective sample of patients with BPH, CaP and AGA. AR gene polymorphism (SNP rs6152) can have impact not only on incidence but also on course of androgen rece...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 4 883 tis. Kč
    • •
  • 4 510 tis. Kč
    • •
  • MZ
Project

Development of new effective strategy to identify high-risk women for endometrial cancer (NU21-09-00031)

for the development of hyperplasia and/or associated with the progression to adenocarcinoma remain...

Oncology

  • 2021 - 2024
    • •
  • 9 834 tis. Kč
    • •
  • 9 834 tis. Kč
    • •
  • MZ
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