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10 448 (0,15s) •

Project

Membrane signalosomes of mast cells and basophils - targets for innovative therapies (LD12073)

important for antigen-induced adhesion and chemotaxis in mast cells. 3. To determine new modulators (inhibitors/activators) of antigen-induced degranulation, adhesionThe aim of this project is: 1. To contribute to determin...

EC - Imunologie

  • 2012 - 2014
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • MŠMT
Project

Molecular mechanisms of signalling through immunoreceptors (GA204/99/0367)

of signalling processes used by immunoreceptors (TCR, BCR, Fc-receptors) will be examined the hypothesis that the first step initiating signal transduction after the immunoreceptor of the endocytic vesicles formed after ligation an...

CE - Biochemie

  • 1999 - 2001
    • •
  • 1 359 tis. Kč
    • •
  • 1 359 tis. Kč
    • •
  • GA ČR
Project

Sensing of HIV-1 by plasmacytoid dendritic cells dichotomy of immunoreceptor signaling (GA14-32547S)

. In contrast to HIV-1 infected lymphocytes, HIV-1 virions are weak inducers of IFN-I. Exposure of pDCs to HIV-1-infected lymphocytes induces robust IFN-I production via Toll/inhibitory immunoreceptors of pDCs, BDCA-2 and D...

EE - Mikrobiologie, virologie

  • 2014 - 2018
    • •
  • 6 397 tis. Kč
    • •
  • 6 397 tis. Kč
    • •
  • GA ČR
Project

New signaling pathways induced in mast cells by cholesterol-dependent cytolysins (GA23-07736S)

minutes of activation, they release a variety of preformed inflammatory mediators by immunoreceptors, there is a pathway utilized by cholesterol-dependent cytolysins (CDCs preliminary data, that CDCs at sublytic concentrations ...

Immunology

  • 2023 - 2025
    • •
  • 9 951 tis. Kč
    • •
  • 9 657 tis. Kč
    • •
  • GA ČR
Project

ORMDL sphingolipid biosynthesis regulator 2 in immunoreceptor activation (GA17-20915S)

we found that ORMDL3 is a negative regulator of activation by the high-affinity IgE receptor (FcεRI) in mast cells. Function of ORMDL2 in immunoreceptor signaling analysis of the role of ORMDL2 in FcεRI activation in vivo ...

EC - Imunologie

  • 2017 - 2021
    • •
  • 8 217 tis. Kč
    • •
  • 7 671 tis. Kč
    • •
  • GA ČR
Project

Center of molecular and cellular immunology (LN00A026)

of supramolecular (domain) organization of plasma cell membrane and immunoreceptor interactions...

EC - Imunologie

  • 2000 - 2004
    • •
  • 115 858 tis. Kč
    • •
  • 76 500 tis. Kč
    • •
  • MŠMT
Project

Molecular Aspects of B-cell Receptor Signal Initiation as Targets for Specific Therapy of non-Hodgkin Lymphoma. (NV18-03-00117)

at least two types of BCR signaling, the “chronic active” (similar to antigen induced activation during phosphorylation of BCR co-receptor molecules CD79A/B and that those......

Oncology

  • 2018 - 2022
    • •
  • 11 156 tis. Kč
    • •
  • 11 156 tis. Kč
    • •
  • MZ
Project

Harnessing soluble forms of NK cell receptors and their ligands for the generation of novel anticancer immunotherapeutics (GA15-15181S)

structural biology and biochemistry. Ligands of NK cell activation receptors immunotherapeutics their ability to induce specific anticancer cytotoxic response......

EC - Imunologie

  • 2015 - 2019
    • •
  • 6 313 tis. Kč
    • •
  • 6 313 tis. Kč
    • •
  • GA ČR
Project

Center of Molecular and Cellular Immunology (1M0506)

toxins and other natural and synthetic immunomodulators) in activation of macrophages proteins; (b) relevant recombinant proteins (biologically active fragments o......

EC - Imunologie

  • 2005 - 2011
    • •
  • 242 918 tis. Kč
    • •
  • 215 618 tis. Kč
    • •
  • MŠMT
Project

Utilization of integrative molecular biophysical approaches for the functional studies of human natural killer cell receptors and formation of their complexes with tumour ligands (LTC17065)

Receptors of natural killer (NK) cells may trigger the lysis of virally infected or tumour cells. Utilizing integrative molecular biophysical approaches, we aim to characterize complex formation for selected immunoreceptors of human NK cell ...

BO - Biofyzika

  • 2017 - 2020
    • •
  • 3 751 tis. Kč
    • •
  • 3 751 tis. Kč
    • •
  • MŠMT
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