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843 (0,093s) •

Project

Sensing of HIV-1 by plasmacytoid dendritic cells dichotomy of immunoreceptor signaling (GA14-32547S)

-like receptor 7 (TLR7). We hypothesize that binding of HIV-1 virions to regulatory/inhibitory immunoreceptors of pDCs, BDCA-2 and DCIR, inhibits IFN-I production. Our objective is to identify and target this inhibitory...

EE - Mikrobiologie, virologie

  • 2014 - 2018
    • •
  • 6 397 tis. Kč
    • •
  • 6 397 tis. Kč
    • •
  • GA ČR
Project

Sensing of hepatitis B virus-infected hepatocytes by plasmacytoid dendritic cells (GA17-15422S)

The role of plasmacytoid dendritic cells (pDCs), a major source of interferon (IFN) alpha in human organism, in pathogenesis of hepatitis B virus (HBV) infection is not clear. We hypothesize that pDCs could be involved via production of IFN-alpha and...

EE - Mikrobiologie, virologie

  • 2017 - 2021
    • •
  • 7 608 tis. Kč
    • •
  • 6 891 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of signalling through immunoreceptors (GA204/99/0367)

Based on previous projects of our laboratory, molecular details of early phases of signalling processes used by immunoreceptors (TCR, BCR, Fc-receptors) will be examined the hypothesis that the first step initiating signal transduction after...

CE - Biochemie

  • 1999 - 2001
    • •
  • 1 359 tis. Kč
    • •
  • 1 359 tis. Kč
    • •
  • GA ČR
Project

The identification and the characterization of the leukemia-inhibitory factor gene mutations in the population of women with idiopathic infertility (GA301/02/1232)

regulatory factor of the mutual communication between the blastocyst and the endometrium is the leukemia-inhibitory factor (LIF) coded by gene on the 22nd chromosome. The main goal......

FK - Gynekologie a porodnictví

  • 2002 - 2004
    • •
  • 1 700 tis. Kč
    • •
  • 1 700 tis. Kč
    • •
  • GA ČR
Project

Center of molecular and cellular immunology (LN00A026)

of supramolecular (domain) organization of plasma cell membrane and immunoreceptor interactions...

EC - Imunologie

  • 2000 - 2004
    • •
  • 115 858 tis. Kč
    • •
  • 76 500 tis. Kč
    • •
  • MŠMT
Project

Signaling pathways involved in mast cell chemotaxis (GA14-09807S)

are involved in immunoreceptor signaling. In this project we will test our hypothesis of the plasma membrane regulatory units (signalosomes) and their roles in mast cell......

EC - Imunologie

  • 2014 - 2016
    • •
  • 7 035 tis. Kč
    • •
  • 7 035 tis. Kč
    • •
  • GA ČR
Project

Regulatory roles of LAIR-1 (CD305) in mast cell physiology and mastocytosis (GA24-12572S)

Mast cells are immune cells with multifaceted functions during homeostasis and in various diseases. Increasing evidence suggests that an intricate network of inhibitory and activating receptors governs mast cell responsiveness to various sti...

Immunology

  • 2024 - 2026
    • •
  • 10 476 tis. Kč
    • •
  • 9 891 tis. Kč
    • •
  • GA ČR
Project

ORMDL sphingolipid biosynthesis regulator 2 in immunoreceptor activation (GA17-20915S)

ORMDL1,2, and 3 proteins are key regulators of serine palmitoyltransferase, which catalyzes the initial steps in sphingolipid synthesis. In our previous study we found that ORMDL3 is a negative regulator of activation by the high-affinity IgE recepto...

EC - Imunologie

  • 2017 - 2021
    • •
  • 8 217 tis. Kč
    • •
  • 7 671 tis. Kč
    • •
  • GA ČR
Project

The role of spinal inhibitory neurons in the development of painful states. (GA20-19136S)

is to study modulation of inhibitory mechanisms of synaptic transmission in the spinal and selective optical stimulation of inhibitory neurons will be used. We will study of inhibitory postsynaptic currents and modulation ...

Neurosciences (including psychophysiology)

  • 2020 - 2022
    • •
  • 6 209 tis. Kč
    • •
  • 6 209 tis. Kč
    • •
  • GA ČR
Project

Optimisation of rhizobial symbiosis of pea (Pisum sativum L.) (GA521/06/0590)

will be monitored. Regulatory links acting at the symbiosis establishment and at the development inhibitory factors should be preserved. The anticipated use of molecular markers should......

GE - Šlechtění rostlin

  • 2006 - 2008
    • •
  • 2 190 tis. Kč
    • •
  • 2 190 tis. Kč
    • •
  • GA ČR
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