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493 (0,088s) •

Project

The study of immunopathogenesis of sarcoidosis and cryptogenic fibrosing alveolitis. (IZ2251)

FP - Ostatní lékařské obory

  • 1994 - 1998
    • •
  • 2 353 tis. Kč
    • •
  • 2 520 tis. Kč
    • •
  • MZ
Project

The role of STAT 5 protein in cytokine-mediated signaling in normal and malignant human breast epithelium (KJB502070601)

JAK/STAT signaling pathway operating downstream of cytokine receptors is involved in regulation of a variety of critical cellular processes including cell of transcription 5) may be involved in interferon and estrogen signaling path...

EB - Genetika a molekulární biologie

  • 2006 - 2007
    • •
  • 590 tis. Kč
    • •
  • 590 tis. Kč
    • •
  • AV ČR
Project

Difficult to control asthma bronchiale The significance of some cytokines in its pathogenesis and the possibility of therapeutic intervention. (IZ1960)

FR - Farmakologie a lékárnická chemie

  • 1994 - 1996
    • •
  • 296 tis. Kč
    • •
  • 442 tis. Kč
    • •
  • MZ
Project

De novo development of bivalent protein binders mimicking the function of interferons lambda (GA19-17398S)

The goal of the project is to design, produce, and test bivalent protein binders mimicking the function of recently discovered pro-inflammatory cytokines, interferons lambda (IFN-λ). IFN-λs promise safer clinical applications agains...

Biochemistry and molecular biology

  • 2019 - 2021
    • •
  • 8 421 tis. Kč
    • •
  • 8 421 tis. Kč
    • •
  • GA ČR
Project

Nanoimmunosensors for detection of cytokines (KAN200520702)

and especially of cytokines. Four academic groups have joined forces here with three research of interferon gamma detection in defined solutions, as well as in real biological samples......

EC - Imunologie

  • 2007 - 2011
    • •
  • 61 744 tis. Kč
    • •
  • 52 198 tis. Kč
    • •
  • AV ČR
Project

A mouse genetic model to study the control of interferon and inflammation (GA19-16963S)

sensor proteins that activate interferon expression. One sensor that detects virus interferon levels and widespread cell death. Adar1; Mavs double mutant mice that lack sensor. We will define the type of aberrant expression of ...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 7 961 tis. Kč
    • •
  • 7 379 tis. Kč
    • •
  • GA ČR
Project

The role and abnormalities of STAT1 in mediating the immunological and antiproliferative effects of Interferon-alpha in malignant melanoma (GA301/00/0564)

Although cytokine-based therapy of cancer has several years history its effectiveness is less than expected or hoped for. More knowledge about cytokine induced signalling pathways and their defective functioning in cancer is urgentl...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 3 360 tis. Kč
    • •
  • 3 040 tis. Kč
    • •
  • GA ČR
Project

Exprimental pharmacotherapy of chronic myelogenous leukemia the proteomic approach (NL7681)

The molecular mechanisms of therapeutic effects of cytokine Interferon - alfa, signal transduction inhibitor STI571, proteasome inhibitor and photodynamic therapy will be studied at the protein level. By proteome analysis methods (t...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 9 659 tis. Kč
    • •
  • 9 374 tis. Kč
    • •
  • MZ
Project

Interferon induced transmembrane proteins as potential targets in cancer therapy (GJ18-23773Y)

Immunity plays important roles at different stages of tumour development and in therapy responses. Interferons are immunoregulatory cytokines, that regulate tumour growth by direct effects on target cells and by activating immune re...

Cell biology

  • 2018 - 2022
    • •
  • 5 065 tis. Kč
    • •
  • 5 065 tis. Kč
    • •
  • GA ČR
Project

Structure-function relationships underlying protein-protein interactions (GAP305/10/2184)

interferon in complex with its cellular and viral receptors, an extensive computational analysis of residue interactions and forces governing high-affinity binding of cytokine by rational design of enhanced cytokine bindin...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 8 276 tis. Kč
    • •
  • 8 276 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 493