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2 901 (0,146s) •

Project

Functional Analysis of Babesia Calcium-Dependent Protein Kinases (GA21-11299S)

of these parasites are orchestrated by a wide repertoire of molecules including the calcium-dependent protein kinases (CDPKs). This project is dedicated to the unbiased screen Kinase Inhibitors (BKIs) to evaluate ...

Biochemistry and molecular biology

  • 2021 - 2024
    • •
  • 12 818 tis. Kč
    • •
  • 12 818 tis. Kč
    • •
  • GA ČR
Project

Calcium signaling to microtubules in activated mast cells (GA16-25159S)

and degranulation. Previously we have shown that activation results in generation of calcium-dependent protrusions containing microtubules. However, corresponding signaling pathway is unknown. Recently we have found that calciu...

EA - Morfologické obory a cytologie

  • 2016 - 2018
    • •
  • 6 075 tis. Kč
    • •
  • 5 781 tis. Kč
    • •
  • GA ČR
Project

Microtubule nucleation in activated mast cells regulatory role of phosphorylated GIT proteins (GA18-27197S)

signaling pathway is unknown. Recently we have found that kinases from PAK and calcium immune responses. Activation of mast cells results in calcium influx, reorganization of microtubules (MT) and degranulation. We have sh...

Cell biology

  • 2018 - 2020
    • •
  • 6 998 tis. Kč
    • •
  • 6 140 tis. Kč
    • •
  • GA ČR
Project

Calcium signaling in neonatal rat gonadotrophs (IAA5011105)

and extracellular Ca2+ dependence of refilling of intracellular calcium stores.Intracellular calcium plays an important role in regulation of many cellular receptor coupled to G protein which stimulates oscillatory cal...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 2 917 tis. Kč
    • •
  • 848 tis. Kč
    • •
  • AV ČR
Project

Anoxic tolerance and Ca2+ homeostasis of right and left ventricular myocytes isolated from chronically hypoxic hearts (IAA500110804)

. This project will focus on chamber- and time-dependent protective effects of chronic IH- and caffeine-induced calcium transients will provide information on calcium homeostasis. The subcellular distribution of protein

ED - Fyziologie

  • 2008 - 2010
    • •
  • 1 512 tis. Kč
    • •
  • 1 512 tis. Kč
    • •
  • AV ČR
Project

Neurohumoral control of calcium influx nifedipine-sensitive component of blood pressure in experimental hypertension (IAA500110902)

) and nitric oxide (NO) in the control of calcium influx through nifedipine-sensitive voltage-dependent calcium channels (VDCC) in blood vessels of normotensive and hypertensive rats. Our parallel in vivo and in vitro exper...

ED - Fyziologie

  • 2009 - 2011
    • •
  • 4 157 tis. Kč
    • •
  • 4 157 tis. Kč
    • •
  • AV ČR
Project

Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors (GA301/08/1649)

Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA transcription. A variety of genetic events cause universal overactivity of the cell cycle cdks in human cancers, ant their inhibition can lead...

FD - Onkologie a hematologie

  • 2008 - 2012
    • •
  • 6 985 tis. Kč
    • •
  • 6 985 tis. Kč
    • •
  • GA ČR
Project

Alpha2delta auxiliary subunit of voltage-dependent Ca2+ channels as a novel therapeutic target for the treatment of hypertension (GP14-16225P)

) and elevated calcium current in vascular smooth muscle cells (VSMC). Voltage-dependent calcium channels (VDCC) play an important role in both increased sympathetic surface localization of these channels and hence calc...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2014 - 2016
    • •
  • 2 919 tis. Kč
    • •
  • 2 919 tis. Kč
    • •
  • GA ČR
Project

Characterization of kinase activity of cyclin-dependent kinase 11 (CDK11), an essential enzyme for the growth of cancer (GA21-19266S)

Cyclin-dependent kinase 11 (CDK11) is a little-studied, but essential protein that drives the growth of many cancers. Its molecular functions are virtually unknown, this finding likely explains why fast-growing cancer cells are ...

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 12 375 tis. Kč
    • •
  • 12 375 tis. Kč
    • •
  • GA ČR
Project

Ultrastructural localisation of intracellular calcium deposits during the growth and maturation mammalian oocytes (GA524/98/1327)

other factors, calcium signalling depends on the status of its intracellular deposits. The object of this project is to detect changes in intracellular calciumCalcium represents one of the most important intracell...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 1998 - 2000
    • •
  • 3 203 tis. Kč
    • •
  • 3 200 tis. Kč
    • •
  • GA ČR
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