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10 (0,086s) •

Project

Study of RNA Editing in Transcripts from Maxicircle Kinetoplast DNA of Trypanosoma Carassii, Trypanosoma Boissoni and Bodo Caudatus (Kinetoplastida). (GA204/94/0285)

EE - Mikrobiologie, virologie

  • 1994 - 1996
    • •
  • 300 tis. Kč
    • •
  • 450 tis. Kč
    • •
  • GA ČR
Project

Determining the function of an essential protein, MIX, within the cytochrome c oxidase of Kinetoplastida (KJB500960901)

MIX is a unique mitochondrial (mt) protein found only within the order Kinetoplastida, which includes the medically important parasites Trypanosoma spp. and Leishmania spp.. Importantly, MIX is essential for cell viability and even the delet...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 1 145 tis. Kč
    • •
  • 1 145 tis. Kč
    • •
  • AV ČR
Project

Structure characterization of g-RNA from Trypanosoma brucei (1K04011)

parazitic Kinetoplastidas....

BO - Biofyzika

  • 2004 - 2006
    • •
  • 2 507 tis. Kč
    • •
  • 1 843 tis. Kč
    • •
  • MŠMT
Project

Phylogeny of bodonid and coccidian protozoa based on small subunit rRNA and conserved protein sequences (IAA6022903)

Our aim is to study phylogenetic relationship of selected bodonid and coccidian protozoa based on the small subunit (SSU) rRNA and conserved protein sequences. Primitive flagellates of the suborder Bodonia (order Kinetoplastida) represent im...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 3 536 tis. Kč
    • •
  • 1 353 tis. Kč
    • •
  • AV ČR
Project

Phlebotomus orientalis salivary proteins and the host antibody response (GA13-05292S)

Sand flies (Diptera: Phlebotominae) are bloodfeeding insects and vectors of Leishmania parasites (Kinetoplastida: Trypanosomatidae), the causative agents of leishmaniases. During bloodfeeding, sand flies inject saliva into the host skin. The...

EG - Zoologie

  • 2013 - 2016
    • •
  • 6 935 tis. Kč
    • •
  • 6 935 tis. Kč
    • •
  • GA ČR
Project

Evolution of kinetoplast DNA structure and RNA editing in primitive kinetoplastida (GA204/00/1212)

Kinetoplastid protozoa is a group of early-branching eukaryots that retain several unique structures and processes, like kinetoplast DNA (kDNA) and RNA editing. We want to characterize the kDNA structure by analyzing the sequence, topology, abundance...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 1 980 tis. Kč
    • •
  • 1 606 tis. Kč
    • •
  • GA ČR
Project

Vývoj a pohlavní rozmnožování Leishmania donovani v různých druzích flebotomů. (GA13-07500S)

Leishmaniases are human diseases transmitted by sand flies (Diptera: Psychodidae) with a wide spectrum of clinical manifestations; visceral disease caused by Leishmania donovani (Kinetoplastida: Trypanosomatidae) being even fatal. The proje...

EG - Zoologie

  • 2013 - 2016
    • •
  • 7 199 tis. Kč
    • •
  • 7 199 tis. Kč
    • •
  • GA ČR
Project

Avian trypanosomes biodiversity, vectors, and factors influencing prevalence (GA14-02482S)

Despite being widespread, avian trypanosomes (Kinetoplastida: Trypanosoma) are understudied parasites. Over 100 species have been described, however few sequence data were obtained and analyzed (SSU rDNA, gGAPDH). Our pilot study revealed 12...

EG - Zoologie

  • 2014 - 2017
    • •
  • 7 784 tis. Kč
    • •
  • 7 784 tis. Kč
    • •
  • GA ČR
Project

Targeting a unique mRNA decapping enzyme for trypanosomatid infectious disease drug discovery and biotechnology applications (GF24-14298L)

Kinetoplastids encode no homologues of canonical mRNA decapping enzymes. Instead, we identified the ApaH-like phosphatase ALPH1 fulfilling this role. ALPH1 is meeting key criteria of a robust drug target: (i) Essentiality for T. brucei viability (ii)...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 7 991 tis. Kč
    • •
  • 7 991 tis. Kč
    • •
  • GA ČR
Project

Vliv hmyzího přenašeče na projevy onemocnění působeného Leishmania infantum (GA206/09/0777)

Leishmaniases are vector-borne diseases with a wide spectrum of clinical forms. Their causative agents, protozoans of the genus Leishmania (Kinetoplastida: Trypanosomatidae), are transmitted by phlebotomine sand flies (Diptera: Psychodidae)....

EG - Zoologie

  • 2009 - 2012
    • •
  • 4 477 tis. Kč
    • •
  • 4 477 tis. Kč
    • •
  • GA ČR
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