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1 781 (0,1s) •

Project

RNA editing in non-model flagellates (GA22-01026S)

Armed with new tools to analyze canonical and non-canonical RNA editing at the level of singular events, we will study this process in non-model trypanosomatids and other euglenozoans. In addition, we propose to scrutinize the structure of kineto...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 432 tis. Kč
    • •
  • 8 906 tis. Kč
    • •
  • GA ČR
Project

Study of RNA Editing in Transcripts from Maxicircle Kinetoplast DNA of Trypanosoma Carassii, Trypanosoma Boissoni and Bodo Caudatus (Kinetoplastida). (GA204/94/0285)

EE - Mikrobiologie, virologie

  • 1994 - 1996
    • •
  • 300 tis. Kč
    • •
  • 450 tis. Kč
    • •
  • GA ČR
Project

Evolution of kinetoplast DNA structure and RNA editing in primitive kinetoplastida (GA204/00/1212)

Kinetoplastid protozoa is a group of early-branching eukaryots that retain several unique structures and processes, like kinetoplast DNA (kDNA) and RNA editing. We want to characterize the kDNA structure by analyzing the sequence, t...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 1 980 tis. Kč
    • •
  • 1 606 tis. Kč
    • •
  • GA ČR
Project

Phylogeny of bodonid and coccidian protozoa based on small subunit rRNA and conserved protein sequences (IAA6022903)

Our aim is to study phylogenetic relationship of selected bodonid and coccidian protozoa based on the small subunit (SSU) rRNA and conserved protein sequences. Primitive flagellates of the suborder Bodonia (order Kinetoplastida) represent important m...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 3 536 tis. Kč
    • •
  • 1 353 tis. Kč
    • •
  • AV ČR
Project

Kinetoplastic endosymbionts in amoebae of the genus Neoparamoeba Page, 1987 (GA206/05/2384)

The aim of the submitted proposal is to elucidate phylogeny of the eukaryotic organism living as endosymbiont in amoebae of the genus Neoparamoeba Page, 1987. The project is based on our previous finding that the symbiont is dosely related to the kín...

EA - Morfologické obory a cytologie

  • 2005 - 2007
    • •
  • 2 196 tis. Kč
    • •
  • 2 196 tis. Kč
    • •
  • GA ČR
Project

Applications of chemical structural probes and electroanalytical methods in DNA damage detection. Development of DNA sensors. (KJB4004302)

In this project we propose to employ chemical probing of DNA structure, in connection with biochemical methods and electrochemical detection, in analysis of DNA damage. Monitoring of DNA-damaging pollutants in the environme...

CG - Elektrochemie

  • 2003 - 2005
    • •
  • 2 052 tis. Kč
    • •
  • 1 212 tis. Kč
    • •
  • AV ČR
Project

Translesion DNA synthesis across lesions induced by agents of biological significance. An insight into energetics, kinetics and mechanism (GA17-09436S)

The biological effects of DNA-damaging physical and chemical agents are associated with their ability to affect DNA replication. The main objective of DNA due to its damage by DNA-damaging agents is an important fa...

BO - Biofyzika

  • 2017 - 2019
    • •
  • 5 627 tis. Kč
    • •
  • 5 006 tis. Kč
    • •
  • GA ČR
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

Interactions of tumor suppressor protein p53 with DNA are crucial for its-specific DNA binding, but also ability of both wt and mutant (mut) p53 to recognize DNA and mut p53 interactions with damaged DNA, particula...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
Project

Development of electrochemical biodetectors for DNA damage (IAA4004108)

electrochemical biodetector (biosensor) for DNA damage (both in vitro and in cells) and DNA damaging agents. A procedure developed in our laboratory which allows to detect DNA strand breaks using mercury electrodes modifie...

CG - Elektrochemie

  • 2001 - 2003
    • •
  • 1 758 tis. Kč
    • •
  • 804 tis. Kč
    • •
  • AV ČR
Project

Extrachromosomal circular DNA and its impact on the evolution of plant satellite DNA (GP204/06/P360)

Satellite DNA formed by long arrays of repetitive tandemly arranged nucleotide recombination between repetitive units leading to formation of circular satellite DNA could extrachromosomal circular DNA with special impact on...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 947 tis. Kč
    • •
  • 947 tis. Kč
    • •
  • GA ČR
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