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1 106 (0,103s) •

Project

Pathophysiological mechanisms of spontaneous hypertension and salt sensitivity (NR8545)

The isolated infuence of genes localized in segment of chromozoma 18 on hypertension will be investigated using renal transplantation of kidneys from SHR-18 congenic strain into SHR recipients. The gene expression profiling...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2005 - 2007
    • •
  • 3 025 tis. Kč
    • •
  • 2 985 tis. Kč
    • •
  • MZ
Project

Positional cloning of a gene on chromosome 18 that is repsonsible for hypertension and salt sensitivity in the spontaneously hypertensive rat (GA301/04/0390)

congenic strain from the SHR, by transferring a segment of chromosome 18 between D18Rat12 and D18Rat32 markers from the Brown Norway (BN/Cr) strain onto the SHR/Ola genetic background. The SHR-18 congenic...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 3 828 tis. Kč
    • •
  • 3 828 tis. Kč
    • •
  • GA ČR
Project

Pathogenesis of cardiovascular risk factors cluster analyzed by transgenesis with Srebp1c transcription factor (NB6468)

this hypothesis, we developed an SHR.BN-Srebp1 congenic strain by transferring a segment of chromosome 10 with the Srebp1c gene from the Brown Norway(BN) strain on the genetic background of the SHR. The congenic strain...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 5 033 tis. Kč
    • •
  • 3 454 tis. Kč
    • •
  • MZ
Project

Genetic and correlation analysis of a complex metabolic syndrome in spontaneously hypertensive rats (GA306/97/0521)

, only on interstrain comparisons of SHR with normotensive control strains lipoproteins in SHR using our recombinant inbred and SHR-congenic strains. We will also ofhypertension, e. g. the spontaneously hy...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1997 - 1999
    • •
  • 2 203 tis. Kč
    • •
  • 1 473 tis. Kč
    • •
  • GA ČR
Project

Pathogenesis of spontaneous hypertension integrated analysis of intermediary phenotypes of autonomic/sympathetic system and gene expression profiles in rat recombinant inbred strains (IAA500110604)

in the pathogenesis of metabolic syndrome using recombinant inbred (RI) strains derived from the SHR (spontaneously hypertensive rat) and BN (Brown Norway) progenitors. Genome of RI strains is covered by more than 1000 gen...

EB - Genetika a molekulární biologie

  • 2006 - 2009
    • •
  • 2 872 tis. Kč
    • •
  • 2 872 tis. Kč
    • •
  • AV ČR
Project

The role of Plzf (Promyelocytic leukemia zinc finger) gene in the pathogenesis of cardiovascular and metabolic disturbances in rat models (GAP301/10/0756)

these hypotheses in vivo, using unique animal models: SHR (spontaneously hypertensive rat, a model of hypertension and metabolic syndrome) and PD3+PD5 - two congenic strains differing from SHR by a small fragment of chromo...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 5 980 tis. Kč
    • •
  • 5 980 tis. Kč
    • •
  • GA ČR
Project

Cardiac ischemic tolerance of spontaneously hypertensive rats involvement of mitochondrial genome (GA13-10267S)

ischemic tolerance of SHR and conplastic strains SHR-mitoBN, -mitoF344 and -mitoLEW with replaced mitochondrial genome from more I/R resistant strains Brown Norway, Fischer 344Spontaneously hypertesive rats (S...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2017
    • •
  • 10 690 tis. Kč
    • •
  • 10 690 tis. Kč
    • •
  • GA ČR
Project

Identification of molecular and functional basis of pathophysiological phenotypes in the spontaneously hypertensive rat (LH12061)

and Westernblot studies of kidney and other relevant tissues in the SHR and BN progenitor strains and in SHR.BN congenic strains. After confirming the loss of function, we strategy. Wewill derive SHR transgenic li...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 4 500 tis. Kč
    • •
  • 3 750 tis. Kč
    • •
  • MŠMT
Project

Systems genetic approach for identifying genes predisposing to salt-sensitive hypertension in the rat (LUAUS25164)

(RI) HXB/BXH strains (N=30) derived from salt-sensitive SHR rats and salt-resistant normotensive BN (Brown Norway) rats. The HXB/BXH RI strains represent a model pressure. Systolic blood pressure was measured telemetricall...

Cardiac and Cardiovascular systems

  • 2025 - 2028
    • •
  • 5 172 tis. Kč
    • •
  • 5 172 tis. Kč
    • •
  • MŠMT
Project

The role of brown adipose tissue in the pathogenesis of metabolic syndrome in the rat genetic and correlation analyses (GA13-04420S)

comorbidities, including type 2 diabetes. The spontaneously hypertensive rat (SHR of lipid and glucose metabolism in the BXH/HXB recombinant inbred strains derived from the SHR.......

EB - Genetika a molekulární biologie

  • 2013 - 2017
    • •
  • 9 104 tis. Kč
    • •
  • 9 104 tis. Kč
    • •
  • GA ČR
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