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38 (0,181s) •

Project

Fusogenic envelope glycoproteins of human endogenous retroviruses and their receptors (GA301/09/2031)

Several human endogenous retroviruses encode fusogenic envelope glycoproteins of endogenous retroviruses with the use of our original method for screening the retroviral, inducible packaging of reporter retroviruses and qua...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 3 715 tis. Kč
    • •
  • 3 715 tis. Kč
    • •
  • GA ČR
Project

Expression of fusogenic human endogenous retroviruses in germ line tumors. (GA13-37600S)

Human endogenous retroviruses have been implicated in tumorigenesis as a source of promoters for aberrant gene expression. Furthermore, several members of the HERV-K family encode bona fide oncogenes, which affect the development of testicul...

FD - Onkologie a hematologie

  • 2013 - 2017
    • •
  • 5 833 tis. Kč
    • •
  • 5 833 tis. Kč
    • •
  • GA ČR
Project

Structural Basis of Inhibition of the Proteinase of Human Immunodeficiency Virus (HIV) and Proteinases of Other Retroviruses (GA203/93/0305)

CE - Biochemie

  • 1993 - 1995
    • •
  • 470 tis. Kč
    • •
  • 940 tis. Kč
    • •
  • GA ČR
Project

CpG methylation of human endogenous retroviruses and LINEs (GA204/05/0939)

repeats of human endogenous retroviruses with special regard to W family(HERV-Ws...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 3 647 tis. Kč
    • •
  • 3 647 tis. Kč
    • •
  • GA ČR
Project

Cell culture for propagation of prions influence of cell culture proliferation and expression of endogenous retroviruses (GP310/09/P260)

could be retroviruses respectively endogenous retroviruses.Investigation of some and significance of expression of endogenous retroviruses in infected cells is aim......

EE - Mikrobiologie, virologie

  • 2009 - 2011
    • •
  • 1 629 tis. Kč
    • •
  • 1 629 tis. Kč
    • •
  • GA ČR
Project

Functional characterization of Avian Sarcoma and Leukosis Virus receptors (GA17-23675S)

Avian sarcoma and leukosis viruses (ASLV) are economically important tumor-inducing retroviruses infecting chickens. Six ASLV subgroups, A-E and J, have been defined by differential usage of four receptors, TVA, TVB, TVC and TVJ available da...

EE - Mikrobiologie, virologie

  • 2017 - 2021
    • •
  • 6 819 tis. Kč
    • •
  • 6 261 tis. Kč
    • •
  • GA ČR
Project

Pattern of DNA methylation in retroviral regulatory sequences (GA204/01/0632)

CpG methylation of proviral DNA is the key mechanism of transcriptional regulation of retroviruses by the host cell. We and others have obtained preliminary data that the sequence-specific pattern of methylation, i.e. the methylation status ...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 657 tis. Kč
    • •
  • 2 210 tis. Kč
    • •
  • GA ČR
Project

In vitro preparation of recombinant capsids for nucleic acids incorporation and internalization in the cell tissue (GP203/03/P094)

The study of retroviruses intensifies during the last years not only because of their responsibility for the AIDS disease and oncogenic effects on humans, but also for their abilities to bind and incorporate nucleic acids and probably eventh...

EE - Mikrobiologie, virologie

  • 2003 - 2005
    • •
  • 750 tis. Kč
    • •
  • 750 tis. Kč
    • •
  • GA ČR
Project

Regulation of active endogenous retroviruses in the mammalian genome (LK11215)

Characterization of epigenetic regulations in a unique model of a highly polymorphic mammalian endogenous retrovirus. Genetic and virological characterization of this endogenous retrovirus. Searching for a similar polymorphism in other mammalian spec...

EE - Mikrobiologie, virologie

  • 2012 - 2016
    • •
  • 14 077 tis. Kč
    • •
  • 14 077 tis. Kč
    • •
  • MŠMT
Project

Integration preference of retroviruses (GA204/07/1030)

We have described by mapping of cloned integration sites that HIV-1 proviruses integrate preferentially into GC-rich genomic compartments with high gene density and into cytogenetic R bands. Furthermore, we sequenced 57 integration sites of Rous sarc...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 4 218 tis. Kč
    • •
  • 4 218 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 38